Molecular Biology Reports, Год журнала: 2021, Номер 48(8), С. 1 - 15
Опубликована: Июль 31, 2021
Язык: Английский
Oncogene, Год журнала: 2019, Номер 39(5), С. 953 - 974
Опубликована: Окт. 10, 2019
Язык: Английский
Процитировано
187
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(17), С. 9451 - 9451
Опубликована: Авг. 31, 2021
With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with major key parameters that control treatment management, such as diagnosis, resistance to classical and new chemotherapeutic reagents continues be a significant problem. Intrinsic or acquired chemoresistance leads recurrence in many cases eventually causes failure successful death patients. Various determinants, including tumor heterogeneity microenvironment, could through diverse range mechanisms. In this review, we summarize determinants underlying mechanisms by which appears. We then describe strategies have been implemented studied combat lethal phenomenon management treatment, emphasis on need improve early diagnosis complemented combination therapy.
Язык: Английский
Процитировано
177
Journal of Cellular and Molecular Medicine, Год журнала: 2018, Номер 22(6), С. 3238 - 3245
Опубликована: Март 30, 2018
Emerging evidence has validated the vital role of long non-coding RNA (lncRNA) in chemoresistance cancer treatment. In present study, we investigate function lncRNA NR2F1-AS1 on oxaliplatin (OXA) resistance hepatocellular carcinoma (HCC) and discover underlying molecular mechanism. Results revealed that was up-regulated oxaliplatin-resistant HCC tissue cells using microarray analysis RT-PCR. Meanwhile, ABCC1 protein overexpressed OXA-resistant (Huh7/OXA HepG2/OXA). vitro, knockdown reduced invasion, migration, drug-resistant gene (MDR1, MRP5, LRP1) IC50 value Huh7/OXA HepG2/OXA cells. vivo, decreased tumour weight Bioinformatics tools luciferase reporter assay confirmed miR-363 targeted 3'-UTR mRNA, presenting promoted expression through endogenous sponging miR-363. summary, results conclude regulates OXA targeting miR-363-ABCC1 pathway, providing a theoretic mechanism therapeutic target for chemoresistance.
Язык: Английский
Процитировано
140
Journal of Cellular Physiology, Год журнала: 2019, Номер 235(4), С. 3189 - 3206
Опубликована: Окт. 8, 2019
Abstract Gastric cancer is the third leading cause of death with 5‐year survival rate about 30–35%. Since early detection associated decreased mortality, identification novel biomarkers for diagnosis and proper management patients best response to therapy urgently needed. Long noncoding RNAs (lncRNAs) due their high specificity, easy accessibility in a noninvasive manner, as well aberrant expression under different pathological physiological conditions, have received great attention potential diagnostic, prognostic, or predictive biomarkers. They may also serve targets treating gastric cancer. In this review, we highlighted role lncRNAs tumor suppressors oncogenes that make them prognosis Relatively, such H19 , HOTAIR UCA1 PVT1 tissue differentiation‐inducing nonprotein coding, LINC00152 could be diagnostic prognostic markers Also, impact ecCEBPA MLK7‐AS1 TUG1 HOXA11‐AS GAPLINC LEIGC multidrug resistance‐related upregulated lncRNA, on epigenetic drug resistance therapeutic personalized medicine was discussed.
Язык: Английский
Процитировано
124
Journal of Cellular Biochemistry, Год журнала: 2018, Номер 119(7), С. 6296 - 6308
Опубликована: Апрель 16, 2018
Abstract Dysregulation of lncRNAs is implicated in chemoresistance varieties tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma‐associated 1 (UCA1) was reported to play an oncogenic role AML. However, whether UCA1 involved pediatric AML remains unclear. expression patients after adriamycin (ADR)‐based chemotherapy and ADR‐resistant cells examined by qRT‐PCR. The effects on the cytotoxicity ADR glycolysis were evaluated MTT assay measuring glucose consumption lactate production HL60 HL60/ADR cells, repectively. protein levels hypoxia‐inducible factor 1α (HIF‐1α) hexokinase 2 (HK2) determined Western blot. Luciferase reporter RNA immunoprecipitation (RIP) used confirm relationships between UCA1, HK2, miR‐125a. We found that upregulated following ADR‐based chemotherapy. Knockdown increased cytotoxic effect inhibited HIF‐1α‐dependent cells. Additionally, functioned as a ceRNA miR‐125a directly binding target miR‐125a, positively regulated More notably, overexpression overturned miR‐125‐mediated inhibition Furthermore, 2‐deoxy‐glucose (2‐DG) exposure glycolysis, attenuated UCA1‐induced increase conclude knockdown plays positive overcoming AML, through suppressing miR‐125a/HK2 pathway, contributing better understanding molecular mechanism
Язык: Английский
Процитировано
105
Cancer Cell International, Год журнала: 2018, Номер 18(1)
Опубликована: Окт. 22, 2018
Primary or acquired resistance to cetuximab often occurs during targeted therapy in metastatic colorectal cancer (mCRC) patients. In many cancers, the key role of long noncoding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) anticancer drug has been confirmed. Emerging evidence shown that specific exosomal lncRNAs may serve as meaningful biomarkers. this study, we hypothesize UCA1 might predict response CRC patients.First, cetuximab-resistant cell lines were generated, and expressions these cells their exosomes compared. We also systematically evaluate stability UCA1. Thereafter, predictive value patients treated with was evaluated. Finally, through apoptosis assays immunofluorescence staining, analyzed UCA1-containing conferring resistance.UCA1 expression markedly higher exosomes. Exosomal be detectable stable serum from addition, circulating could clinical outcome patients, considerably progressive disease/stable disease than partial response/complete Furthermore, derived alter transmit sensitive cells.We discovered a novel exosomes, showed capability investigated potential use predicting resistance.
Язык: Английский
Процитировано
102
Frontiers in Oncology, Год журнала: 2018, Номер 8
Опубликована: Авг. 29, 2018
Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption of their function through somatic mutations, genomic imprinting, transcriptional and post-transcriptional regulation, plays an ever-increasing role cancer development. ncRNAs, including notorious microRNAs, thus proposed to as tumour suppressors or oncogenes, often a context-dependent fashion. In parallel, ncRNAs with altered expression reported exert key determining drug sensitivity restoring responsiveness resistant cells. Acquisition resistance anti-cancer drugs is major hindrance effective chemotherapy one the important causes relapse mortality patients. For these reasons, non-coding become recent focuses prognostic agents modifiers chemo-sensitivity. This review starts brief outline studied then highlights modulation via known based mechanisms. We identified from literature 388 ncRNA-drugs interactions analysed them using novel unsupervised approach. Essentially, we performed network analysis direct relations drugs. Applying such framework detected representative ncRNAs-drug associations groups. finally discussed higher integration drug-ncRNA clusters goal disentangling effectors downstream effects further clarify involvement mechanisms underlying treatments.
Язык: Английский
Процитировано
99
Seminars in Cancer Biology, Год журнала: 2020, Номер 83, С. 303 - 318
Опубликована: Ноя. 15, 2020
Язык: Английский
Процитировано
96
International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(11), С. 2615 - 2615
Опубликована: Май 28, 2019
Long noncoding RNAs (lncRNAs) are a class of transcripts longer than 200 nucleotides with no open reading frame. They play key role in the regulation cellular processes such as genome integrity, chromatin organization, gene expression, translation regulation, and signal transduction. Recent studies indicated that lncRNAs not only dysregulated different types diseases but also function direct effectors or mediators for many pathological symptoms. This review focuses on current findings their signaling pathways senescence. Different functional mechanisms downstream integrated to provide bird’s-eye view lncRNA networks highlights cell fate decision discusses how several feedback loops interconnected execute persistent senescence response. Finally, significance senescence-associated therapeutic diagnostic potentials highlighted.
Язык: Английский
Процитировано
93
Pathology - Research and Practice, Год журнала: 2023, Номер 247, С. 154570 - 154570
Опубликована: Май 24, 2023
Язык: Английский
Процитировано
41