Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Май 5, 2023
Osteoporosis
is
an
age-related
disease
of
bone
metabolism
marked
by
reduced
mineral
density
and
impaired
strength.
The
causes
the
bones
to
weaken
break
more
easily.
Osteoclasts
participate
in
resorption
than
osteoblasts
formation,
disrupting
homeostasis
leading
osteoporosis.
Currently,
drug
therapy
for
osteoporosis
includes
calcium
supplements,
vitamin
D,
parathyroid
hormone,
estrogen,
calcitonin,
bisphosphates,
other
medications.
These
medications
are
effective
treating
but
have
side
effects.
Copper
a
necessary
trace
element
human
body,
studies
shown
that
it
links
development
Cuproptosis
recently
proposed
new
type
cell
death.
Copper-induced
death
regulates
lipoylated
components
mediated
via
mitochondrial
ferredoxin
1;
is,
copper
binds
directly
tricarboxylic
acid
cycle,
resulting
protein
accumulation
subsequent
loss
iron-sulfur
cluster
proteins,
proteotoxic
stress
eventually
Therapeutic
options
tumor
disorders
include
targeting
intracellular
toxicity
cuproptosis.
hypoxic
environment
metabolic
pathway
glycolysis
provide
energy
cells
can
inhibit
cuproptosis,
which
may
promote
survival
proliferation
various
cells,
including
osteoblasts,
osteoclasts,
effector
T
macrophages,
thereby
mediating
process.
As
result,
our
group
tried
explain
relationship
between
role
cuproptosis
its
essential
regulatory
genes,
as
well
pathological
mechanism
effects
on
cells.
This
study
intends
investigate
treatment
approach
clinical
beneficial
Clinical Endocrinology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
ABSTRACT
Objective
Premature
ovarian
insufficiency
(POI),
the
loss
of
function
before
age
40,
increases
risk
cardiovascular
disease,
low
bone
mineral
density,
dementia
and
psychological
distress.
Lifestyle
interventions
reduce
chronic
disease
in
other
populations
and,
with
hormone
therapy,
may
improve
health
outcomes
POI.
This
review
aims
to
identify
role
lifestyle,
including
diet
physical
activity,
managing
symptoms,
improving
quality
life
(QoL)
preventing
women
The
findings
this
informed
2024
update
ESHRE
Evidence‐Based
POI
Guideline.
Design
A
systematic
search
was
conducted
PubMed
Medline
databases
from
January
2014
February
2024.
included
randomized
controlled
trials
quasi‐experimental
that
examined
impact
lifestyle
on
Outcomes
menopause
QoL,
health.
Risk
bias
assessed
using
Joanna
Briggs
Institute
critical
appraisal
tool.
Results
literature
yielded
890
citations,
one
study
meeting
inclusion
criteria.
Two
additional
studies
guideline
chapter
searches
were
included,
totalling
three
articles.
involved
cancer
survivors
those
Turner
syndrome.
Limited
evidence
suggests
interventions,
particularly
density
effect
dietary
supplementation
mixed.
Conclusions
While
a
healthy
is
proven
prevent
diseases
QoL
postmenopausal
women,
there
limited
specific
Targeted
are
needed
determine
most
effective
for
addressing
their
heightened
risks
unmet
needs.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 10, 2025
Despite
extensive
studies
conducted
on
the
relationship
between
serum
uric
acid
(UA)
and
bone
mineral
density
(BMD),
their
association
remains
controversial.
In
this
study,
we
investigated
whether
UA
levels
are
independently
associated
with
BMD
in
Chinese
American
populations
to
elucidate
association.
Herein,
data
of
12,344
individuals
(age
>
20
years)
from
National
Health
Nutrition
Examination
Survey
(2005–2018)
those
768
inpatient
medical
records
physical
examination
center
systems
Tertiary
Class
A
Hospital
(2021–2023)
China
were
included.
The
was
analyzed
by
employing
multivariate
regression
models
covariate
adjustments.
addition,
population
description,
stratified
analysis,
single-factor
smooth-curve
fitting,
threshold
saturation
effect
analyses
performed.
After
adjustments,
exhibited
an
femur
(β
=
0.008,
95%
confidence
interval
[CI]
0.001–0.015,
P
0.02),
femoral
neck
0.011,
CI
0.004–0.018,
0.002),
lumbar
spine
0.014,
0.06–0.022,
<
0.001)
subjects.
Similarly,
0.079,
0.042–0.117,
0.001),
0.171,
0.121–0.22,
0.052,
0.007–0.097,
0.024)
Notably,
nonlinear.
saturated
utility
values
for
determining
level
using
a
two-stage
linear
model
429.9
468
μmol/L,
respectively,
population.
population,
femur,
neck,
410.4,
452
respectively.
Altogether,
present
findings
suggested
positive
overall
adults,
implying
that
maintaining
can
facilitate
osteoporosis
prevention.
Clinical
Trials
Registry:
MR-51-23-051741.
https://www.medicalresearch.org.cn/search/research/researchViewid=c0e5f868-eca9-4c68-af58-d73460c34028
.
Free Radical Research,
Год журнала:
2022,
Номер
56(1), С. 63 - 76
Опубликована: Янв. 2, 2022
Oxidative
stress
is
an
important
contributor
to
the
development
of
osteoporosis.
Melatonin,
indoleamine
secreted
by
pineal
gland,
has
antioxidant
properties.
This
study
aims
explore
whether
melatonin
can
promote
bone
formation
and
elucidate
mechanisms
underlying
this
process.
In
study,
we
used
in
vitro
hydrogen
peroxide
(H2O2)-induced
oxidative
model
MC3T3-E1
cells
vivo
ovariectomized
osteoporotic
defect
rats
protective
effects
against
defects
along
with
mechanism
these
effects.
We
found
that
significantly
increased
alkaline
phosphatase
activity,
mineralization
capacity,
expression
BMP2,
RUNX2,
OPN
treated
H2O2.
Furthermore,
was
activate
SIRT1,
SIRT3
inhibit
p66Shc,
reduce
intracellular
reactive
oxygen
species
levels,
stabilize
mitochondria,
malondialdehyde
increase
superoxide
dismutase
apoptosis
Intriguingly,
could
be
reversed
SIRT1
inhibitor
EX527.
experiments
confirmed
improves
microstructure
mineral
density
distal
femoral
trabecula
promotes
formation.
Meanwhile,
activated
inhibited
p66Shc
expression.
Taken
together,
our
findings
showed
restrain
damage
osteogenesis
activating
which
regulate
activity
suggesting
a
potential
therapeutic
agent
for
osteoporosis-related
metabolic
diseases.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Май 5, 2023
Osteoporosis
is
an
age-related
disease
of
bone
metabolism
marked
by
reduced
mineral
density
and
impaired
strength.
The
causes
the
bones
to
weaken
break
more
easily.
Osteoclasts
participate
in
resorption
than
osteoblasts
formation,
disrupting
homeostasis
leading
osteoporosis.
Currently,
drug
therapy
for
osteoporosis
includes
calcium
supplements,
vitamin
D,
parathyroid
hormone,
estrogen,
calcitonin,
bisphosphates,
other
medications.
These
medications
are
effective
treating
but
have
side
effects.
Copper
a
necessary
trace
element
human
body,
studies
shown
that
it
links
development
Cuproptosis
recently
proposed
new
type
cell
death.
Copper-induced
death
regulates
lipoylated
components
mediated
via
mitochondrial
ferredoxin
1;
is,
copper
binds
directly
tricarboxylic
acid
cycle,
resulting
protein
accumulation
subsequent
loss
iron-sulfur
cluster
proteins,
proteotoxic
stress
eventually
Therapeutic
options
tumor
disorders
include
targeting
intracellular
toxicity
cuproptosis.
hypoxic
environment
metabolic
pathway
glycolysis
provide
energy
cells
can
inhibit
cuproptosis,
which
may
promote
survival
proliferation
various
cells,
including
osteoblasts,
osteoclasts,
effector
T
macrophages,
thereby
mediating
process.
As
result,
our
group
tried
explain
relationship
between
role
cuproptosis
its
essential
regulatory
genes,
as
well
pathological
mechanism
effects
on
cells.
This
study
intends
investigate
treatment
approach
clinical
beneficial
