Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 16, 2024
Sepsis
is
a
life-threatening
organ
dysfunction
caused
by
the
host’s
dysfunctional
response
to
infection.
Abnormal
activation
of
immune
system
and
disturbance
energy
metabolism
play
key
role
in
development
sepsis.
In
recent
years,
Sirtuins
(SIRTs)
family
has
been
found
an
important
pathogenesis
SIRTs,
as
class
histone
deacetylases
(HDACs),
are
widely
involved
cellular
inflammation
regulation,
oxidative
stress.
The
effects
SIRTs
on
cells
mainly
reflected
regulation
inflammatory
pathways.
This
helps
balance
may
lessen
cell
damage
terms
metabolism,
can
immunophenotypic
transformation
regulating
improve
mitochondrial
function,
increase
production,
maintain
balance.
also
regulate
production
reactive
oxygen
species
(ROS),
protecting
from
stress
activating
antioxidant
defense
pathways
maintaining
between
oxidants
reducing
agents.
Current
studies
have
shown
that
several
potential
drugs,
such
Resveratrol
melatonin,
enhance
activity
SIRT.
It
help
reduce
response,
stress,
showing
clinical
application
prospects
for
treatment
review
focuses
SIRT
cells,
well
its
influence
multiple
sepsis,
discusses
summarizes
related
drugs
compounds
sepsis
through
pathway
involving
SIRTs.
become
new
target
resulting
dysfunction,
providing
ideas
possibilities
this
disease.
Pharmacological Research,
Год журнала:
2023,
Номер
194, С. 106835 - 106835
Опубликована: Июнь 20, 2023
Maintaining
mitochondrial
homeostasis
is
a
potential
therapeutic
strategy
for
various
diseases,
including
neurodegenerative
cardiovascular
metabolic
disorders,
and
cancer.
Selective
degradation
of
mitochondria
by
autophagy
(mitophagy)
fundamental
quality
control
mechanism
conserved
from
yeast
to
humans.
Indeed,
small-molecule
modulators
mitophagy
are
valuable
pharmaceutical
tools
that
can
be
used
dissect
complex
biological
processes
turn
them
into
drugs.
In
the
past
few
years,
pharmacological
regulation
has
shown
promising
efficacy
in
disease
models.
However,
with
increasing
number
chemical
modulator
studies,
frequent
methodological
flaws
observed,
leading
some
studies
draw
unreliable
or
misleading
conclusions.
This
review
attempts
(a)
summarize
molecular
mechanisms
mitophagy;
(b)
propose
Mitophagy
Modulator
Characterization
System
(MMCS);
(c)
perform
comprehensive
analysis
methods
characterize
modulators,
covering
publications
over
20
years;
(d)
provide
novel
targets
intervention
mitophagy.
We
believe
this
will
panorama
current
research
on
promote
development
safe
robust
introducing
high
standards.
Polydatin
(PD),
a
natural
product
derived
from
Polygonum
cuspidatum,
has
anti-inflammatory
and
antioxidant
effects
significant
benefits
in
treating
allergic
diseases.
However,
its
role
mechanism
rhinitis
(AR)
have
not
been
fully
elucidated.
Herein,
we
investigated
the
effect
of
PD
AR.
AR
model
was
established
mice
with
OVA.
Human
nasal
epithelial
cells
(HNEpCs)
were
stimulated
IL-13.
HNEpCs
also
treated
an
inhibitor
mitochondrial
division
or
transfected
siRNA.
The
levels
IgE
cellular
inflammatory
factors
examined
by
enzyme
linked
immunosorbent
assay
flow
cytometry.
expressions
PINK1,
Parkin,
P62,
LC3B,
NLRP3
inflammasome
proteins,
apoptosis
proteins
tissues
measured
Western
blot.
We
found
that
suppressed
OVA-induced
thickening
eosinophil
accumulation
mucosa,
reduced
IL-4
production
NALF,
regulated
Th1/Th2
balance.
In
addition,
mitophagy
induced
after
OVA
challenge
IL-13
stimulation.
Meanwhile,
enhanced
PINK1-Parkin-mediated
but
decreased
reactive
oxygen
species
(mtROS)
production,
activation,
apoptosis.
PD-induced
abrogated
PINK1
knockdown
Mdivi-1
treatment,
indicating
key
PINK1-Parkin
mitophagy.
Moreover,
damage,
mtROS
under
exposure
more
severe
treatment.
Conclusively,
may
exert
protective
on
promoting
mitophagy,
which
further
suppresses
tissue
damage
through
decreasing
activation.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 16, 2024
Sepsis
is
a
life-threatening
organ
dysfunction
caused
by
the
host’s
dysfunctional
response
to
infection.
Abnormal
activation
of
immune
system
and
disturbance
energy
metabolism
play
key
role
in
development
sepsis.
In
recent
years,
Sirtuins
(SIRTs)
family
has
been
found
an
important
pathogenesis
SIRTs,
as
class
histone
deacetylases
(HDACs),
are
widely
involved
cellular
inflammation
regulation,
oxidative
stress.
The
effects
SIRTs
on
cells
mainly
reflected
regulation
inflammatory
pathways.
This
helps
balance
may
lessen
cell
damage
terms
metabolism,
can
immunophenotypic
transformation
regulating
improve
mitochondrial
function,
increase
production,
maintain
balance.
also
regulate
production
reactive
oxygen
species
(ROS),
protecting
from
stress
activating
antioxidant
defense
pathways
maintaining
between
oxidants
reducing
agents.
Current
studies
have
shown
that
several
potential
drugs,
such
Resveratrol
melatonin,
enhance
activity
SIRT.
It
help
reduce
response,
stress,
showing
clinical
application
prospects
for
treatment
review
focuses
SIRT
cells,
well
its
influence
multiple
sepsis,
discusses
summarizes
related
drugs
compounds
sepsis
through
pathway
involving
SIRTs.
become
new
target
resulting
dysfunction,
providing
ideas
possibilities
this
disease.
