SIRT3 deficiency exacerbates early-stage fibrosis after ischaemia-reperfusion-induced AKI

Cellular Signalling, Journal Year: 2022, Volume and Issue: 93, P. 110284 - 110284

Published: Feb. 16, 2022

Language: Английский

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Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms

Pharmacological Research, Journal Year: 2023, Volume and Issue: 194, P. 106835 - 106835

Published: June 20, 2023

Maintaining mitochondrial homeostasis is a potential therapeutic strategy for various diseases, including neurodegenerative cardiovascular metabolic disorders, and cancer. Selective degradation of mitochondria by autophagy (mitophagy) fundamental quality control mechanism conserved from yeast to humans. Indeed, small-molecule modulators mitophagy are valuable pharmaceutical tools that can be used dissect complex biological processes turn them into drugs. In the past few years, pharmacological regulation has shown promising efficacy in disease models. However, with increasing number chemical modulator studies, frequent methodological flaws observed, leading some studies draw unreliable or misleading conclusions. This review attempts (a) summarize molecular mechanisms mitophagy; (b) propose Mitophagy Modulator Characterization System (MMCS); (c) perform comprehensive analysis methods characterize modulators, covering publications over 20 years; (d) provide novel targets intervention mitophagy. We believe this will panorama current research on promote development safe robust introducing high standards.

Language: Английский

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Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1‐Parkin‐mediated mitophagy in allergic rhinitis

The FASEB Journal, Journal Year: 2023, Volume and Issue: 37(4)

Published: March 11, 2023

Polydatin (PD), a natural product derived from Polygonum cuspidatum, has anti-inflammatory and antioxidant effects significant benefits in treating allergic diseases. However, its role mechanism rhinitis (AR) have not been fully elucidated. Herein, we investigated the effect of PD AR. AR model was established mice with OVA. Human nasal epithelial cells (HNEpCs) were stimulated IL-13. HNEpCs also treated an inhibitor mitochondrial division or transfected siRNA. The levels IgE cellular inflammatory factors examined by enzyme linked immunosorbent assay flow cytometry. expressions PINK1, Parkin, P62, LC3B, NLRP3 inflammasome proteins, apoptosis proteins tissues measured Western blot. We found that suppressed OVA-induced thickening eosinophil accumulation mucosa, reduced IL-4 production NALF, regulated Th1/Th2 balance. In addition, mitophagy induced after OVA challenge IL-13 stimulation. Meanwhile, enhanced PINK1-Parkin-mediated but decreased reactive oxygen species (mtROS) production, activation, apoptosis. PD-induced abrogated PINK1 knockdown Mdivi-1 treatment, indicating key PINK1-Parkin mitophagy. Moreover, damage, mtROS under exposure more severe treatment. Conclusively, may exert protective on promoting mitophagy, which further suppresses tissue damage through decreasing activation.

Language: Английский

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The role and therapeutic potential of SIRTs in sepsis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 16, 2024

Sepsis is a life-threatening organ dysfunction caused by the host’s dysfunctional response to infection. Abnormal activation of immune system and disturbance energy metabolism play key role in development sepsis. In recent years, Sirtuins (SIRTs) family has been found an important pathogenesis SIRTs, as class histone deacetylases (HDACs), are widely involved cellular inflammation regulation, oxidative stress. The effects SIRTs on cells mainly reflected regulation inflammatory pathways. This helps balance may lessen cell damage terms metabolism, can immunophenotypic transformation regulating improve mitochondrial function, increase production, maintain balance. also regulate production reactive oxygen species (ROS), protecting from stress activating antioxidant defense pathways maintaining between oxidants reducing agents. Current studies have shown that several potential drugs, such Resveratrol melatonin, enhance activity SIRT. It help reduce response, stress, showing clinical application prospects for treatment review focuses SIRT cells, well its influence multiple sepsis, discusses summarizes related drugs compounds sepsis through pathway involving SIRTs. become new target resulting dysfunction, providing ideas possibilities this disease.

Language: Английский

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Research progress on the role and mechanism of Sirtuin family in doxorubicin cardiotoxicity

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155673 - 155673

Published: April 22, 2024

Language: Английский

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