Ageing Research Reviews, Год журнала: 2022, Номер 78, С. 101617 - 101617
Опубликована: Апрель 1, 2022
Язык: Английский
Nature Reviews Endocrinology, Год журнала: 2021, Номер 17(9), С. 534 - 548
Опубликована: Июнь 25, 2021
Язык: Английский
Процитировано
399
Advanced Science, Год журнала: 2021, Номер 8(18)
Опубликована: Июль 28, 2021
Abstract Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although large drug portfolio exists to keep the levels under control, these medications are not without side effects. More importantly, once diagnosed rarely reversible. Dysfunctions in kidney, retina, cardiovascular system, neurons, liver represent common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, molecular mechanisms how type develops leads irreparable damage remain elusive. This review particularly focuses on novel targets may play role pathogenesis diabetes. Further research eventually pave way for treatment—or even prevention—of along with its complications.
Язык: Английский
Процитировано
339
Nutrients, Год журнала: 2021, Номер 13(1), С. 183 - 183
Опубликована: Янв. 9, 2021
Type 2 diabetes mellitus (T2DM) represents a major health burden for the elderly population, affecting approximately 25% of people over age 65 years. This percentage is expected to increase dramatically in next decades relation increased longevity population observed recent Beyond microvascular and macrovascular complications, sarcopenia has been described as new complication population. Increasing attention paid by researchers clinicians this age-related condition—characterized loss skeletal muscle mass together with power function—in individuals T2DM; due heavy impact that may have on physical psychosocial diabetic patients, thus their quality life. The aim narrative review provide an update on: (1) risk T2DM, (2) its association relevant features patients T2DM such age, gender, body index, disease duration, glycemic control, presence or nutritional status, glucose-lowering drugs. From clinical point view, it necessary improve ability physicians dietitians recognize early factors order make appropriate therapeutic approaches able prevent treat condition.
Язык: Английский
Процитировано
275
The journal of nutrition health & aging, Год журнала: 2020, Номер 24(6), С. 665 - 671
Опубликована: Май 13, 2020
To estimate the prevalence of sarcopenia in different ethnic groups and association with cultural life styles west China.
Язык: Английский
Процитировано
204
Cells, Год журнала: 2022, Номер 11(1), С. 160 - 160
Опубликована: Янв. 4, 2022
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related sarcopenia is characterized by decreased muscular strength, muscle quantity, quality, functional performance. Sarcopenic obesity (SO) condition that combines has substantial influence older adults’ health. Because of complicated pathophysiology, there are disagreements challenges in identifying diagnosing SO. Recently, it become clear dysbiosis may play role onset progression Skeletal secretes myokines during contraction, which an important controlling growth, function, metabolic balance. Myokine dysfunction can cause aggravate obesity, sarcopenia, The only ways to prevent slow particularly sarcopenic physical activity correct nutritional support. While exercise cannot completely age-related loss certainly delay development down rate sarcopenia. purpose this review was discuss potential pathways deterioration obese individuals. We also want present current understanding various factors, including microbiota myokines, process
Язык: Английский
Процитировано
144
Biogerontology, Год журнала: 2023, Номер 24(5), С. 609 - 662
Опубликована: Июль 30, 2023
Язык: Английский
Процитировано
84
Diabetes Metabolic Syndrome and Obesity, Год журнала: 2023, Номер Volume 16, С. 1541 - 1554
Опубликована: Май 1, 2023
Abstract: Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass function, is recognized a new complication in elderly patients with type 2 diabetes mellitus (T2DM). Type insulin resistance, chronic inflammation, accumulation advanced glycation products increased oxidative stress, which can negatively affect mass, strength function leading to sarcopenia. There mutual interrelationship between T2DM light pathophysiology mechanism long-term outcome. will accelerate the decline turn lead glucose metabolism disorders, reduced physical activity risk diabetes. However, specific involved has not been thoroughly studied. Therefore, this review aims explore therapeutic strategy related provide insight for future investigations, great significance improving quality life concurrently reducing incidence complications. Keywords: mellitus, sarcopenia, gut microbiota,
Язык: Английский
Процитировано
61
Biomedicines, Год журнала: 2023, Номер 11(1), С. 136 - 136
Опубликована: Янв. 5, 2023
Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have higher risk falls may be associated with heart disease, respiratory diseases, cognitive impairment, consequently an increased hospitalization, in addition causing economic impact high cost care during stay hospitals. The standardization appropriate treatment for patients sarcopenia that could help reduce pathology-related morbidity necessary. For these reasons, this study aimed perform systematic review role nutrition drugs ameliorate health quality life sarcopenic PRISMA guidelines were followed. Lifestyle interventions shown profound on but using supplements different can also skeletal maintenance. Creatine, leucine, branched-chain amino acids, omega 3, vitamin D show benefits. Although controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, dipeptidyl peptidase 4 inhibitors been considered alter sarcopenic's metabolic parameters, protect against cardiovascular diseases outcomes, while protecting muscles.
Язык: Английский
Процитировано
50
Metabolism, Год журнала: 2023, Номер 146, С. 155637 - 155637
Опубликована: Июнь 21, 2023
Sarcopenia is a geriatric condition characterized by progressive loss of skeletal muscle mass and strength, with an increased risk adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality life, mortality). Pharmacological remedies are currently unavailable for preventing the development sarcopenia, halting its progression, or impeding negative outcomes. The most effective strategies to contrast sarcopenia rely on adoption healthier lifestyle behaviors, including adherence high-quality diets regular physical activity. In this review, role nutrition in prevention management summarized. Special attention given current "blockbuster" dietary regimes agents used counteract age-related wasting, together their putative mechanisms action. Issues related design implementation nutritional discussed, focus unanswered questions appropriate timing interventions preserve function into old age. A brief description also provided new technologies that can facilitate personalized plans sarcopenia.
Язык: Английский
Процитировано
48
Nature Reviews Endocrinology, Год журнала: 2024, Номер 20(8), С. 447 - 459
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
41