Sarcopenia and Chronic Complications of Type 2 Diabetes Mellitus DOI Open Access
Dyah Purnamasari, Erpryta Nurdia Tetrasiwi,

Gracia Jovita Kartiko

et al.

The Review of Diabetic Studies, Journal Year: 2022, Volume and Issue: 18(3), P. 157 - 165

Published: Sept. 28, 2022

Sarcopenia, defined as the loss of skeletal muscle mass and strength and/or a decrease in physical performance, is classically related to aging. However, chronic disease, including type 2 diabetes mellitus (T2DM), may accelerate development sarcopenia. Previous studies found strong association between T2DM Insulin resistance that exists thought be key mediator for impaired function mobility which lead cause sarcopenia through mediation insulin resistance, inflammation, accumulation advanced glycation end-products, oxidative stress affect strength, protein metabolism, vascular mitochondrial dysfunction. On other hand, play role decreased production myokines glucose fat metabolism. This review highlights findings existing literature on relationship emphasize pathophysiology, complications, course macrovascular microvascular complications T2DM.

Language: Английский

Type 2 diabetes mellitus in older adults: clinical considerations and management DOI
Srikanth Bellary, Ioannis Kyrou, James E. Brown

et al.

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(9), P. 534 - 548

Published: June 25, 2021

Language: Английский

Citations

387
Emerging Targets in Type 2 Diabetes and Diabetic Complications DOI Creative Commons
Sevgican Demir, Peter P. Nawroth, Stephan Herzig

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 8(18)

Published: July 28, 2021

Abstract Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although large drug portfolio exists to keep the levels under control, these medications are not without side effects. More importantly, once diagnosed rarely reversible. Dysfunctions in kidney, retina, cardiovascular system, neurons, liver represent common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, molecular mechanisms how type develops leads irreparable damage remain elusive. This review particularly focuses on novel targets may play role pathogenesis diabetes. Further research eventually pave way for treatment—or even prevention—of along with its complications.

Language: Английский

Citations

325
A Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors DOI Open Access
Anna Izzo,

Elena Massimino,

Gabriele Riccardi

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 183 - 183

Published: Jan. 9, 2021

Type 2 diabetes mellitus (T2DM) represents a major health burden for the elderly population, affecting approximately 25% of people over age 65 years. This percentage is expected to increase dramatically in next decades relation increased longevity population observed recent Beyond microvascular and macrovascular complications, sarcopenia has been described as new complication population. Increasing attention paid by researchers clinicians this age-related condition—characterized loss skeletal muscle mass together with power function—in individuals T2DM; due heavy impact that may have on physical psychosocial diabetic patients, thus their quality life. The aim narrative review provide an update on: (1) risk T2DM, (2) its association relevant features patients T2DM such age, gender, body index, disease duration, glycemic control, presence or nutritional status, glucose-lowering drugs. From clinical point view, it necessary improve ability physicians dietitians recognize early factors order make appropriate therapeutic approaches able prevent treat condition.

Language: Английский

Citations

267
Ethnic Groups Differences in the Prevalence of Sarcopenia Using the AWGS Criteria DOI Creative Commons
X. Liu, Qiukui Hao, Li Hou

et al.

The journal of nutrition health & aging, Journal Year: 2020, Volume and Issue: 24(6), P. 665 - 671

Published: May 13, 2020

To estimate the prevalence of sarcopenia in different ethnic groups and association with cultural life styles west China.

Language: Английский

Citations

203
Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines DOI Creative Commons
Jan Bilski, Piotr Pierzchalski, Marian Szczepanik

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(1), P. 160 - 160

Published: Jan. 4, 2022

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related sarcopenia is characterized by decreased muscular strength, muscle quantity, quality, functional performance. Sarcopenic obesity (SO) condition that combines has substantial influence older adults’ health. Because of complicated pathophysiology, there are disagreements challenges in identifying diagnosing SO. Recently, it become clear dysbiosis may play role onset progression Skeletal secretes myokines during contraction, which an important controlling growth, function, metabolic balance. Myokine dysfunction can cause aggravate obesity, sarcopenia, The only ways to prevent slow particularly sarcopenic physical activity correct nutritional support. While exercise cannot completely age-related loss certainly delay development down rate sarcopenia. purpose this review was discuss potential pathways deterioration obese individuals. We also want present current understanding various factors, including microbiota myokines, process

Language: Английский

Citations

140
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies DOI
Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma

et al.

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

Citations

79
Prevalence of Sarcopenia and Its Impact on Cardiovascular Events and Mortality among Dialysis Patients: A Systematic Review and Meta-Analysis DOI Open Access
Wannasit Wathanavasin, Athiphat Banjongjit, Yingyos Avihingsanon

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 4077 - 4077

Published: Sept. 30, 2022

Sarcopenia in end-stage kidney disease patients requiring dialysis is a frequent complication but remains an under-recognized problem. This meta-analysis was conducted to determine the prevalence of sarcopenia and explored its impacts on clinical outcomes, especially cardiovascular events, mortality patients. The eligible studies were searched from PubMed, Scopus, Cochrane Central Register Controlled trials up 31 March 2022. We included that reported interested random-effects model used for analysis. Forty-one with 7576 included. pooled 25.6% (95% CI 22.1 29.4%). significantly associated higher risk (adjusted OR 1.83 1.40 2.39)) events 3.80 1.79 8.09)). Additionally, both low muscle mass strength independently related increased (OR 1.71; 95% (1.20 2.44), 2.15 1.51 3.07)), respectively. revealed highly prevalent among shown be important predictor mortality. Future intervention research alleviate this burden needed.

Language: Английский

Citations

70
The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy DOI Creative Commons
Huiling Chen, Xiaojing Huang, Meiyuan Dong

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2023, Volume and Issue: Volume 16, P. 1541 - 1554

Published: May 1, 2023

Abstract: Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass function, is recognized a new complication in elderly patients with type 2 diabetes mellitus (T2DM). Type insulin resistance, chronic inflammation, accumulation advanced glycation products increased oxidative stress, which can negatively affect mass, strength function leading to sarcopenia. There mutual interrelationship between T2DM light pathophysiology mechanism long-term outcome. will accelerate the decline turn lead glucose metabolism disorders, reduced physical activity risk diabetes. However, specific involved has not been thoroughly studied. Therefore, this review aims explore therapeutic strategy related provide insight for future investigations, great significance improving quality life concurrently reducing incidence complications. Keywords: mellitus, sarcopenia, gut microbiota,

Language: Английский

Citations

55
Diet for the prevention and management of sarcopenia DOI Creative Commons
Riccardo Calvani, Anna Picca, Hélio José Coelho‐Júnior

et al.

Metabolism, Journal Year: 2023, Volume and Issue: 146, P. 155637 - 155637

Published: June 21, 2023

Sarcopenia is a geriatric condition characterized by progressive loss of skeletal muscle mass and strength, with an increased risk adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality life, mortality). Pharmacological remedies are currently unavailable for preventing the development sarcopenia, halting its progression, or impeding negative outcomes. The most effective strategies to contrast sarcopenia rely on adoption healthier lifestyle behaviors, including adherence high-quality diets regular physical activity. In this review, role nutrition in prevention management summarized. Special attention given current "blockbuster" dietary regimes agents used counteract age-related wasting, together their putative mechanisms action. Issues related design implementation nutritional discussed, focus unanswered questions appropriate timing interventions preserve function into old age. A brief description also provided new technologies that can facilitate personalized plans sarcopenia.

Language: Английский

Citations

46
Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review DOI Creative Commons

Rodrigo Haber Mellen,

Otávio Simões Girotto,

Eduarda Boni Marques

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(1), P. 136 - 136

Published: Jan. 5, 2023

Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have higher risk falls may be associated with heart disease, respiratory diseases, cognitive impairment, consequently an increased hospitalization, in addition causing economic impact high cost care during stay hospitals. The standardization appropriate treatment for patients sarcopenia that could help reduce pathology-related morbidity necessary. For these reasons, this study aimed perform systematic review role nutrition drugs ameliorate health quality life sarcopenic PRISMA guidelines were followed. Lifestyle interventions shown profound on but using supplements different can also skeletal maintenance. Creatine, leucine, branched-chain amino acids, omega 3, vitamin D show benefits. Although controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, dipeptidyl peptidase 4 inhibitors been considered alter sarcopenic's metabolic parameters, protect against cardiovascular diseases outcomes, while protecting muscles.

Language: Английский

Citations

45