This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(18)
Опубликована: Март 7, 2023
Abstract
As
the
global
population
ages,
bone‐related
diseases
have
increasingly
become
a
major
social
problem
threatening
human
health.
Exosomes,
as
natural
cell
products,
been
used
to
treat
due
their
superior
biocompatibility,
biological
barrier
penetration,
and
therapeutic
effects.
Moreover,
modified
exosomes
exhibit
strong
bone‐targeting
capabilities
that
may
improve
efficacy
avoid
systemic
side
effects,
demonstrating
promising
translational
potential.
However,
review
of
bone‐targeted
is
still
lacking.
Thus,
recently
developed
for
applications
in
this
are
focused.
The
biogenesis
regulatory
functions
exosomes,
constructive
strategies
bone‐targeting,
effects
introduced.
By
summarizing
developments
challenges
It
striven
shed
light
on
selection
exosome
different
bone
highlight
potential
future
clinical
orthopedics.
Abstract
Extracellular
vesicles
(EVs)
play
an
important
role
in
many
physiological
processes.
Thus,
EV
analysis
has
a
great
value
for
the
understanding
of
mechanisms
underlying
disease
progress
or
diagnosis,
prognosis
and
therapy.
The
overlapped
physical
immune
properties
between
EVs
events
body
fluids,
as
well
phenotypic
heterogeneity
EVs,
require
efficient
isolation
methods.
unique
aptamers,
such
facile
modification
programmability,
make
them
easily
assembled
powerful
platforms
analysis.
can
also
be
used
vehicles
drug
delivery,
benefiting
from
homing
ability,
hypo‐immunogenicity,
strong
tolerance.
affinity
recognition
ability
to
targets
feature
single
stranded
DNA
aptamers
useful
promoting
targetability
delivery
nucleic
acid
drugs.
This
review
summarizes
recent
aptamer‐based
isolation,
analysis,
aptamer‐functionalized
therapeutics.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Авг. 21, 2023
Osteoarthritis
(OA)
is
a
common
degenerative
joint
disease
urgently
needing
effective
treatments.
Bone
marrow
mesenchymal
stromal
cell-derived
exosomes
(Exo)
are
considered
good
drug
carriers
whereas
they
have
limitations
such
as
fast
clearance
and
low
retention.
This
study
aimed
to
overcome
the
of
Exo
in
delivery
using
multiple
strategies.
Novel
photocrosslinking
spherical
gelatin
methacryloyl
hydrogel
(GelMA)-encapsulated
cartilage
affinity
WYRGRL
(W)
peptide-modified
engineered
were
developed
for
OA
treatment
performance
(W-Exo@GelMA)
loaded
with
small
inhibitor
LRRK2-IN-1
(W-Exo-L@GelMA)
was
investigated
vitro
vivo.
The
W-Exo-L@GelMA
showed
an
targeting
effect
on
chondrocytes
pronounced
action
suppressing
catabolism
promoting
anabolism
vitro.
Moreover,
remarkably
inhibited
OA-related
inflammation
immune
gene
expression,
rescuing
IL-1β-induced
transcriptomic
responses.
With
enhanced
retention
joint,
demonstrated
superior
anti-OA
activity
repair
ability
murine
model.
therapeutic
validated
cultured
human
cartilage.
In
conclusion,
hydrogel-encapsulated
exhibit
notable
potential
therapy.
Engineering
by
series
strategies
cartilage-targeting
Exo-mediated
may
offer
novel
strategy
treatment.Clinical
trial
registration:
Not
applciable.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 123 - 123
Опубликована: Янв. 7, 2024
Lung
cancer
demands
innovative
approaches
for
early
detection
and
targeted
treatment.
In
addressing
this
urgent
need,
exosomes
play
a
pivotal
role
in
revolutionizing
both
the
treatment
of
lung
cancer.
Their
remarkable
capacity
to
encapsulate
diverse
range
biomolecules,
traverse
biological
barriers,
be
engineered
with
specific
targeting
molecules
makes
them
highly
promising
diagnostic
markers
precise
drug
delivery
cells.
Furthermore,
an
in-depth
analysis
exosomal
content
biogenesis
offers
crucial
insights
into
molecular
profile
tumors.
This
knowledge
holds
significant
potential
development
therapies
strategies
Despite
notable
progress
field,
challenges
standardization
cargo
loading
persist.
Collaborative
research
efforts
are
imperative
maximize
advance
field
precision
medicine
benefit
patients.
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
