Bone‐Targeted Exosomes: Strategies and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 7, 2023

Abstract As the global population ages, bone‐related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, been used to treat due their superior biocompatibility, biological barrier penetration, and therapeutic effects. Moreover, modified exosomes exhibit strong bone‐targeting capabilities that may improve efficacy avoid systemic side effects, demonstrating promising translational potential. However, review of bone‐targeted is still lacking. Thus, recently developed for applications in this are focused. The biogenesis regulatory functions exosomes, constructive strategies bone‐targeting, effects introduced. By summarizing developments challenges It striven shed light on selection exosome different bone highlight potential future clinical orthopedics.

Language: Английский

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Aptamer‐based extracellular vesicle isolation, analysis and therapeutics

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)

Published: March 8, 2023

Abstract Extracellular vesicles (EVs) play an important role in many physiological processes. Thus, EV analysis has a great value for the understanding of mechanisms underlying disease progress or diagnosis, prognosis and therapy. The overlapped physical immune properties between EVs events body fluids, as well phenotypic heterogeneity EVs, require efficient isolation methods. unique aptamers, such facile modification programmability, make them easily assembled powerful platforms analysis. can also be used vehicles drug delivery, benefiting from homing ability, hypo‐immunogenicity, strong tolerance. affinity recognition ability to targets feature single stranded DNA aptamers useful promoting targetability delivery nucleic acid drugs. This review summarizes recent aptamer‐based isolation, analysis, aptamer‐functionalized therapeutics.

Language: Английский

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Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 21, 2023

Osteoarthritis (OA) is a common degenerative joint disease urgently needing effective treatments. Bone marrow mesenchymal stromal cell-derived exosomes (Exo) are considered good drug carriers whereas they have limitations such as fast clearance and low retention. This study aimed to overcome the of Exo in delivery using multiple strategies. Novel photocrosslinking spherical gelatin methacryloyl hydrogel (GelMA)-encapsulated cartilage affinity WYRGRL (W) peptide-modified engineered were developed for OA treatment performance (W-Exo@GelMA) loaded with small inhibitor LRRK2-IN-1 (W-Exo-L@GelMA) was investigated vitro vivo. The W-Exo-L@GelMA showed an targeting effect on chondrocytes pronounced action suppressing catabolism promoting anabolism vitro. Moreover, remarkably inhibited OA-related inflammation immune gene expression, rescuing IL-1β-induced transcriptomic responses. With enhanced retention joint, demonstrated superior anti-OA activity repair ability murine model. therapeutic validated cultured human cartilage. In conclusion, hydrogel-encapsulated exhibit notable potential therapy. Engineering by series strategies cartilage-targeting Exo-mediated may offer novel strategy treatment.Clinical trial registration: Not applciable.

Language: Английский

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Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 123 - 123

Published: Jan. 7, 2024

Lung cancer demands innovative approaches for early detection and targeted treatment. In addressing this urgent need, exosomes play a pivotal role in revolutionizing both the treatment of lung cancer. Their remarkable capacity to encapsulate diverse range biomolecules, traverse biological barriers, be engineered with specific targeting molecules makes them highly promising diagnostic markers precise drug delivery cells. Furthermore, an in-depth analysis exosomal content biogenesis offers crucial insights into molecular profile tumors. This knowledge holds significant potential development therapies strategies Despite notable progress field, challenges standardization cargo loading persist. Collaborative research efforts are imperative maximize advance field precision medicine benefit patients.

Language: Английский

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Recent advances of multifunctional zwitterionic polymers for biomedical application

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 19 - 45

Published: May 8, 2024

Language: Английский

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