The Science of The Total Environment, Год журнала: 2024, Номер 925, С. 171774 - 171774
Опубликована: Март 18, 2024
Язык: Английский
Cell Metabolism, Год журнала: 2021, Номер 33(9), С. 1744 - 1762
Опубликована: Сен. 1, 2021
Язык: Английский
Процитировано
494
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(12), С. 6417 - 6417
Опубликована: Июнь 15, 2021
Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed phospholipid bilayers that carry variety molecules can mediate cell communication, modulating crucial processes such as homeostasis, induction/dampening inflammation, promotion repair. Their existence, initially suspected 1946 confirmed 1967, spurred sharp increase the number scientific publications. Paradoxically, increasing interest for EV content function progressively reduced relevance precise nomenclature classifying EVs, therefore leading to confusing production. The aim this review was analyze evolution progress knowledge definition EVs over years, with an overview methodologies used identification vesicles, their origin, detection cargo. MISEV 2018 guidelines proper recognition ways study summarized. finishes “more questions than answers” chapter, which some problems we still face fully understand potential diagnostic therapeutic tool analyzed.
Язык: Английский
Процитировано
112
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115087 - 115087
Опубликована: Июнь 29, 2023
All forms of life produce nanosized extracellular vesicles called exosomes, which are enclosed in lipid bilayer membranes. Exosomes engage cell-to-cell communication and participate a variety physiological pathological processes. function via their bioactive components, delivered to target cells the form proteins, nucleic acids, lipids. as drug delivery vehicles due unique properties innate stability, low immunogenicity, biocompatibility, biodistribution, accumulation desired tissues, toxicity normal stimulation anti-cancer immune responses, penetration capacity into distance organs. mediate cellular communications by delivering various molecules including oncogenes, oncomiRs, specific DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering (siRNA), circular (circRNA). These substances can be transferred change transcriptome influence tumor-related signaling pathways. After considering all available literature, this review we discuss biogenesis, composition, production, purification exosomes. We briefly exosome isolation techniques. explore great-length exosomes mechanism for substances, chemicals, chemotherapeutic drugs. also talk about benefits drawbacks This concludes with discussion future perspective challenges. hope that will provide us better understanding current state nanomedicine applications biomedicine.
Язык: Английский
Процитировано
62
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7794 - 7794
Опубликована: Июль 16, 2024
Exosomes, small membrane-bound vesicles secreted by cells, have gained significant attention for their therapeutic potential. Measuring 30–100 nm in diameter and derived from various cell types, exosomes play a crucial role intercellular communication transferring proteins, lipids, RNA between cells. This review analyzes existing literature on the clinical applications of exosomes. We conducted comprehensive search peer-reviewed articles trial data to evaluate benefits, limitations, challenges exosome-based therapies. Key areas focus included regenerative medicine, cancer therapy, gene diagnostic biomarkers. highlights vast In facilitate tissue repair regeneration. can deliver agents directly tumor serve as vectors delivery. As biomarkers, they are useful diagnosing diseases. Challenges such isolation, purification, characterization were identified. Current trials demonstrate potential therapies, though also reveal hurdles. Regulatory issues, including need standardization validation exosome products, critical advancing these While progress has been made understanding biology, further research is essential fully unlock Addressing regulatory successful application practice. provides concise overview exosomes, emphasizing both promise obstacles that be overcome.
Язык: Английский
Процитировано
32
Pathology - Research and Practice, Год журнала: 2024, Номер 254, С. 155083 - 155083
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
19
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1923 - 1949
Опубликована: Фев. 1, 2024
Abstract: Exosomes, small extracellular vesicles derived from cells, are known to carry important bioactive molecules such as proteins, nucleic acids, and lipids. These components play crucial roles in cell signaling, immune response, tumor metastasis, making exosomes potential diagnostic biomarkers for various diseases. However, current methods detecting face scientific challenges including low sensitivity, poor specificity, complicated procedures, high costs. It is essential surmount these obstacles enhance the precision dependability of diagnostics that rely on exosomes. Merging DNA signal amplification techniques with boosting capabilities nanomaterials presents an encouraging strategy overcome constraints improve exosome detection. This article highlights use technology nanomaterials' enhancement effect detection review seeks offer valuable perspectives applied practical cancer diagnosis prognosis by providing overview how novel technologies utilized exosome-based procedures. Keywords: tumor, exosomes, nanomaterials,
Язык: Английский
Процитировано
18
Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 7, 2025
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is an asymptomatic, multifaceted condition often associated with various risk factors, including fatigue, obesity, insulin resistance, metabolic syndrome, and sleep apnea. The increasing burden of MASLD underscores the critical need for early diagnosis effective therapies. Owing to lack efficient therapies MASLD, crucial. Consequently, noninvasive biomarkers imaging techniques are essential analyzing play a pivotal role in global diagnostic process. use extracellular vesicles has emerged as promising therapy ailments. Herein, comprehensive summary current modalities presented, highlighting their advantages limitations while exploring potential (EVs) innovative therapeutic tools MASLD. With this aim, review emphasizes in-depth understanding origin EVs pathophysiological alterations these ectosomes exosomes diseases. This also explores key components future management disease. dual utility essentially highlights clinical integration improve treatment. While EV-based still stages development require substantial research increase value before they can be used clinically, application been extensively explored. Moving forward, developing devices leveraging will crucial advancing diagnosis. Thus, literature summarized provides suitable grounds clinicians researchers explore devising treatment strategies
Язык: Английский
Процитировано
3
Frontiers in Oncology, Год журнала: 2025, Номер 14
Опубликована: Янв. 8, 2025
Gynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. These pose a significant threat to women's health, impacting life expectancy, quality of life, and fertility. Nanoparticles, with their small size, large surface area, high permeability, have become key focus in targeted cancer therapy. The aim this study is review recent advancements nanoparticles applied gynecologic cancers, providing valuable insights for future research. We retrieved all literature on from Web Science Core Collection (WOSCC) database between January 1, 2004, June 4, 2024. Data analysis visualization were conducted using R software (version 4.4.0), VOSviewer 1.6.19.0), CiteSpace 6.1). A total 2,843 publications 2024 searched. Over past 20 years, there has been increase publications. leading countries institutions terms productivity China Chinese Academy Sciences. most prolific author co-cited Sood, K Siegel, Rl. top journals International Journal Nanomedicine (n=97), followed ACS Applied Materials & Interfaces (n=72) Chemistry B (n=53). Keyword shows current research focuses two main areas: application drug delivery broader applications cancers. Future will likely "silver nanoparticles," "gold "green synthesis." decades, rapidly advanced field Research primarily focused applications. trends point toward optimizing synthesis techniques advancing preclinical studies clinical applications, particularly silver gold nanoparticles. findings provide scientific researchers.
Язык: Английский
Процитировано
3
Neurochemical Research, Год журнала: 2025, Номер 50(2)
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
2
International Journal of Nanomedicine, Год журнала: 2021, Номер Volume 16, С. 3357 - 3383
Опубликована: Май 1, 2021
Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited and multi-signal messengers loaded with biomolecules. Exosomes ectosomes two different types EVs generated by all cell types. Their formation depends on local microdomains assembled in endocytic membranes for exosomes the plasma membrane ectosomes. Further, EV release is fundamental process required intercellular communication both normal physiology pathological conditions to transmit/exchange bioactive molecules recipient cells extracellular environment. The unique structure composition enable them serve as natural nanocarriers, their physicochemical properties biological functions can be used develop next-generation nano precision medicine. Knowledge cellular processes that govern biology trafficking essential clinical applications. However, this rapidly expanding field, much remains unknown regarding origin, biogenesis, cargo sorting, secretion, well EV-based theranostic platform generation. Hence, we present comprehensive overview recent advances trafficking, EVs, highlighting impact nanoparticles oxidative stress biogenesis finally emphasizing role nanotherapeutic agents.
Язык: Английский
Процитировано
98