Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2276 - 2276
Опубликована: Сен. 4, 2023
Inflammatory
diseases
are
common
pathological
processes
caused
by
various
acute
and
chronic
factors,
some
of
them
autoimmune
diseases.
Exosomes
fundamental
extracellular
vesicles
secreted
almost
all
cells,
which
contain
a
series
constituents,
i.e.,
cytoskeletal
cytosolic
proteins
(actin,
tubulin,
histones),
nucleic
acids
(mRNA,
miRNA,
DNA),
lipids
(diacylglycerophosphates,
cholesterol,
sphingomyelin,
ceramide),
other
bioactive
components
(cytokines,
signal
transduction
proteins,
enzymes,
antigen
presentation
membrane
transport/fusion
molecules,
adhesion
molecules).
This
review
will
be
synopsis
the
knowledge
on
contribution
exosomes
from
different
cell
sources
as
possible
therapeutic
agents
against
inflammation,
focusing
several
inflammatory
diseases,
neurological
rheumatoid
arthritis
osteoarthritis,
intestinal
bowel
disease,
asthma,
liver
kidney
injuries.
Current
indicates
that
role
in
therapy
inflammation
could
distinctive.
The
main
limitations
to
their
clinical
translation
still
production,
isolation,
storage.
Additionally,
there
is
an
urgent
need
personalize
treatments
terms
selection
exosomes;
dosages
routes
administration;
deeper
about
biodistribution,
type
incidence
adverse
events,
long-term
effects
exosomes.
In
conclusion,
can
very
promising
next-generation
option,
superior
synthetic
nanocarriers
therapy,
represent
new
strategy
effective,
safe,
versatile,
selective
delivery
systems
future.
Stem Cell Research & Therapy,
Год журнала:
2023,
Номер
14(1)
Опубликована: Апрель 26, 2023
Abstract
Wound
healing
is
a
dynamic
and
highly
sequential
process
involving
series
of
overlapping
spatial
temporal
phases,
including
hemostasis,
inflammation,
proliferation,
tissue
remodeling.
Mesenchymal
stem
cells
(MSCs)
are
multipotent
with
self-renewal,
multidirectional
differentiation
potential,
paracrine
regulation.
Exosomes
subcellular
vesicular
components
30–150
nm
in
size
novel
carriers
intercellular
communication
regulating
the
biological
behaviors
skin
cells.
Compared
to
MSCs,
MSC-derived
exosomes
(MSC-exos)
possess
lower
immunogenicity,
easy
storage,
effective
activity.
MSC-exos,
mainly
derived
from
adipose-derived
(ADSCs),
bone
marrow-derived
MSCs
(BMSCs),
human
umbilical
cord
(hUC-MSCs),
other
cell
types,
play
role
shaping
activity
fibroblasts,
keratinocytes,
immune
cells,
endothelial
diabetic
wounds,
inflammatory
wound
repair,
even
wound-related
keloid
formation.
Therefore,
this
study
focuses
on
specific
roles
mechanisms
different
MSC-exos
healing,
as
well
current
limitations
various
perspectives.
Deciphering
properties
crucial
providing
promising
cell-free
therapeutic
tool
for
cutaneous
regeneration.
Graphical
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 22, 2022
Background
Autoimmune
diseases
(AIDs)
are
a
class
of
chronic
disabling
characterized
by
inflammation
and
damage
to
muscles,
joints,
bones,
internal
organs.
Recent
studies
have
shown
that
much
progress
has
been
made
in
the
research
exosomes
AIDs.
However,
there
is
no
bibliometric
analysis
this
field.
This
study
aims
provide
comprehensive
overview
knowledge
structure
hotspots
AIDs
through
bibliometrics.
Method
Publications
related
from
2002
2021
were
searched
on
web
science
core
collection
(WoSCC)
database.
VOSviewers,
CiteSpace
R
package
“bibliometrix”
used
conduct
analysis.
Results
312
articles
48
countries
led
China
United
States
included.
The
number
publications
increasing
year
year.
Central
South
University,
Sun
Yat
Sen
Tianjin
Medical
University
Pennsylvania
main
institutions.
Frontiers
immunology
most
popular
journal
field,
Journal
Immunology
co-cited
journal.
These
come
473
authors
among
which
Ilias
Alevizos,
Qianjin
Lu,
Wei
Wei,
Jim
Xiang
Ming
Zhao
had
published
papers
Clotilde
Théry
was
often.
Studying
mechanism
endogenous
occurrence
development
therapeutic
strategy
exogenous
topics
“Mesenchymal
stem
cells”,
“microRNA”,
“biomarkers”,
“immunomodulation”,
“therapy”
primary
keywords
emerging
hotspots.
Conclusion
first
comprehensively
summarizes
trends
developments
information
identifies
recent
frontiers
hot
directions,
will
reference
for
scholars
studying
exosomes.
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Янв. 23, 2023
Abstract
MicroRNAs
(miRNAs)
are
a
group
of
small
non-coding
RNAs
that
regulate
gene
expression
by
targeting
mRNA.
Moreover,
it
has
been
shown
miRNAs
changed
in
various
diseases,
such
as
cancers,
autoimmune
disease,
infectious
and
neurodegenerative
Diseases.
The
suppression
miRNA
function
can
be
easily
attained
utilizing
anti-miRNAs.
In
contrast,
an
enhancement
achieved
through
the
utilization
modified
mimetics.
discovery
appropriate
carriers
body
become
interesting
subject
for
investigators.
Exosomes
(EXOs)
therapeutic
efficiency
safety
transferring
different
cellular
biological
components
to
recipient
cell
have
attracted
significant
attention
their
capability
carriers.
Mesenchymal
stem
cells
(MSCs)
recognized
generate
wide
range
EXOs
(MSC-EXOs),
showing
MSCs
may
effective
EXO
generation
clinically
measure
compared
other
origins.
MSC-EXOs
widely
investigated
because
immune
attributes,
tumor-homing
flexible
characteristics.
this
article,
we
summarized
features
MSC-EXOs,
including
production,
purification,
loading
methods
modification
targeted
delivery
diseases.
Graphical
abstract
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
163, С. 114817 - 114817
Опубликована: Май 2, 2023
Cardiovascular
and
cerebrovascular
diseases
(CVDs)
remain
an
intractable
problem
have
high
morbidity
mortality
worldwide,
as
well
substantial
health
economic
burdens,
representing
urgent
clinical
need.
In
recent
years,
the
focus
of
research
has
shifted
from
use
mesenchymal
stem
cells
(MSCs)
for
transplantation
to
their
secretory
exosomes
(MSC-exosomes)
treatment
numerous
CVDs,
including
atherosclerosis,
myocardial
infarction
(MI),
heart
failure
(HF),
ischemia/reperfusion
(I/R),
aneurysm,
stroke.
MSCs
are
pluripotent
with
multiple
differentiation
pathways
that
exert
pleiotropic
effects
by
producing
soluble
factors,
most
effective
components
which
exosomes.
MSC-exosomes
considered
be
excellent
promising
cell-free
therapy
CVDs
due
higher
circulating
stability,
improved
biocompatibility,
reduced
toxicity,
immunogenicity.
addition,
play
critical
roles
in
repairing
inhibiting
apoptosis,
regulating
inflammation,
ameliorating
cardiac
remodeling,
promoting
angiogenesis.
Herein,
we
describe
knowledge
about
biological
characteristics
MSC-exosomes,
investigate
mechanism
mediate
therapeutic
repair,
summarize
advances
efficacy
a
view
toward
future
applications.
Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1486 - 1486
Опубликована: Май 13, 2023
Mesenchymal
stromal/stem
cells
(MSCs)
and
their
secreted
factors
have
been
shown
to
immunomodulatory
regenerative
effects.
In
this
study,
we
investigated
human
bone-marrow-derived
MSC
secretome
(MSC-S)
for
the
treatment
of
corneal
epithelial
wounds.
Specifically,
evaluated
role
extracellular
vesicles
(EV)/exosomes
in
mediating
wound-healing
effects
MSC-S.
vitro
studies
using
showed
that
MSC-CM
increased
cell
proliferation
HCEC
HCLE
cells,
while
EV-depleted
lower
both
lines
compared
group.
vivo
experiments
revealed
1X
MSC-S
consistently
promoted
wound
healing
more
effectively
than
0.5X
MSC-S,
a
dose-dependent
manner,
exosome
deprivation
delayed
healing.
We
further
incubation
period
on
collected
72
h
is
effective
48
h.
Finally,
stability
under
different
storage
conditions
found
after
one
cycle
freeze–thawing,
stable
at
4
°C
up
weeks.
Collectively,
identified
following:
(i)
MSC-EV/Exo
as
active
ingredient
mediates
epithelium,
providing
measure
optimize
its
dosing
potential
clinical
product;
(ii)
Treatment
with
EV/Exo-containing
resulted
an
improved
barrier
decreased
haze/edema
relative
EV/Exo-depleted
MSC-S;
(iii)
The
weeks
regular
condition
did
not
significantly
impact
therapeutic
functions.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 1597 - 1627
Опубликована: Фев. 1, 2024
Abstract:
The
development
of
numerous
diseases
is
significantly
influenced
by
inflammation.
Macrophage-derived
exosomes
(M-Exos)
play
a
role
in
controlling
inflammatory
reactions
various
conditions,
including
chronic
pain,
hypertension,
and
diabetes.
However,
the
specific
targets
roles
M-Exos
regulating
inflammation
remain
largely
unknown.
This
review
summarizes
current
knowledge
on
biogenesis
provides
updated
information
M-Exos'
biological
function
modulation.
Furthermore,
this
highlights
functionalization
engineering
strategies
M-Exos,
while
providing
an
overview
cutting-edge
approaches
to
advancements
their
application
as
therapeutics
for
Finally,
multiple
mechanisms
are
presented
along
with
perspectives
challenges,
potential
contribution
that
may
have
through
modulation
discussed.
Keywords:
inflammation,
macrophage-derived
exosomes,
functions,
modulation,
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 19, 2024
In
recent
years,
cell
therapy
has
provided
desirable
properties
for
promising
new
drugs.
Mesenchymal
stem
cells
are
candidates
developing
genetic
engineering
and
drug
delivery
strategies
due
to
their
inherent
properties,
including
immune
regulation,
homing
ability
tumor
tropism.
The
therapeutic
potential
of
mesenchymal
is
being
investigated
cancer
therapy,
inflammatory
fibrotic
diseases,
among
others.
attractive
cellular
carriers
synthetic
nanoparticles
ability.
this
review,
we
comprehensively
discuss
the
various
non-genetic
derivatives
in
delivery,
tissue
regeneration
other
fields.
addition,
current
limitations
challenges
clinical
translation,
aiming
identify
important
development
areas
future
directions.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 15, 2024
Abstract
In
recent
decades,
emerging
data
have
highlighted
the
critical
role
of
extracellular
vesicles
(EVs),
especially
(exosomes)
Exos,
in
progression
and
development
several
cancer
types.
These
nano-sized
are
released
by
different
cell
lineages
within
niche
maintain
a
suitable
platform
for
interchange
various
signaling
molecules
paracrine
manner.
Based
on
studies,
Exos
can
transfer
oncogenic
factors
to
other
cells,
alter
activity
immune
tumor
microenvironment,
leading
expansion
cells
metastasis
remote
sites.
It
has
been
indicated
that
cell-to-cell
crosstalk
is
so
complicated
wide
array
involved
this
process.
How
which
mechanisms
regulate
behavior
non-cancer
at
center
debate.
Here,
we
scrutinize
molecular
parenchyma.
Besides,
tumoricidal
properties
from
stem
(SC)
types
discussed
detail.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 12, 2025
Bone-related
diseases
impact
a
large
portion
of
the
global
population
and,
due
to
their
high
disability
rates
and
limited
treatment
options,
pose
significant
medical
economic
challenges.
Mesenchymal
stem
cells
(MSCs)
can
differentiate
into
multiple
cell
types
offer
strong
regenerative
potential,
making
them
promising
for
treating
various
diseases.
However,
issues
with
immune
response
survival
limit
effectiveness
transplantation.
This
has
led
increased
interest
in
cell-free
therapy,
particularly
use
exosomes,
which
is
most
studied
form
this
approach.
Exosomes
are
extracellular
vesicles
that
contain
proteins,
lipids,
nucleic
acids
play
key
role
communication
material
exchange.
Pyroptosis,
death
involved
innate
immunity,
also
associated
many
Studies
have
shown
MSC-derived
exosomes
therapeutic
potential
range
conditions
by
regulating
inflammation
pyroptosis.
study
explored
modulating
pyroptosis
improve
bone-related
