Life Sciences, Journal Year: 2022, Volume and Issue: 312, P. 121206 - 121206
Published: Nov. 18, 2022
Language: Английский
Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 14(1)
Published: April 26, 2023
Abstract Wound healing is a dynamic and highly sequential process involving series of overlapping spatial temporal phases, including hemostasis, inflammation, proliferation, tissue remodeling. Mesenchymal stem cells (MSCs) are multipotent with self-renewal, multidirectional differentiation potential, paracrine regulation. Exosomes subcellular vesicular components 30–150 nm in size novel carriers intercellular communication regulating the biological behaviors skin cells. Compared to MSCs, MSC-derived exosomes (MSC-exos) possess lower immunogenicity, easy storage, effective activity. MSC-exos, mainly derived from adipose-derived (ADSCs), bone marrow-derived MSCs (BMSCs), human umbilical cord (hUC-MSCs), other cell types, play role shaping activity fibroblasts, keratinocytes, immune cells, endothelial diabetic wounds, inflammatory wound repair, even wound-related keloid formation. Therefore, this study focuses on specific roles mechanisms different MSC-exos healing, as well current limitations various perspectives. Deciphering properties crucial providing promising cell-free therapeutic tool for cutaneous regeneration. Graphical
Language: Английский
Citations
126
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: July 22, 2022
Background Autoimmune diseases (AIDs) are a class of chronic disabling characterized by inflammation and damage to muscles, joints, bones, internal organs. Recent studies have shown that much progress has been made in the research exosomes AIDs. However, there is no bibliometric analysis this field. This study aims provide comprehensive overview knowledge structure hotspots AIDs through bibliometrics. Method Publications related from 2002 2021 were searched on web science core collection (WoSCC) database. VOSviewers, CiteSpace R package “bibliometrix” used conduct analysis. Results 312 articles 48 countries led China United States included. The number publications increasing year year. Central South University, Sun Yat Sen Tianjin Medical University Pennsylvania main institutions. Frontiers immunology most popular journal field, Journal Immunology co-cited journal. These come 473 authors among which Ilias Alevizos, Qianjin Lu, Wei Wei, Jim Xiang Ming Zhao had published papers Clotilde Théry was often. Studying mechanism endogenous occurrence development therapeutic strategy exogenous topics “Mesenchymal stem cells”, “microRNA”, “biomarkers”, “immunomodulation”, “therapy” primary keywords emerging hotspots. Conclusion first comprehensively summarizes trends developments information identifies recent frontiers hot directions, will reference for scholars studying exosomes.
Language: Английский
Citations
114
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Jan. 23, 2023
Abstract MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown miRNAs changed in various diseases, such as cancers, autoimmune disease, infectious and neurodegenerative Diseases. The suppression miRNA function can be easily attained utilizing anti-miRNAs. In contrast, an enhancement achieved through the utilization modified mimetics. discovery appropriate carriers body become interesting subject for investigators. Exosomes (EXOs) therapeutic efficiency safety transferring different cellular biological components to recipient cell have attracted significant attention their capability carriers. Mesenchymal stem cells (MSCs) recognized generate wide range EXOs (MSC-EXOs), showing MSCs may effective EXO generation clinically measure compared other origins. MSC-EXOs widely investigated because immune attributes, tumor-homing flexible characteristics. this article, we summarized features MSC-EXOs, including production, purification, loading methods modification targeted delivery diseases. Graphical abstract
Language: Английский
Citations
78
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 12, 2025
Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types offer strong regenerative potential, making them promising for treating various diseases. However, issues with immune response survival limit effectiveness transplantation. This has led increased interest in cell-free therapy, particularly use exosomes, which is most studied form this approach. Exosomes are extracellular vesicles that contain proteins, lipids, nucleic acids play key role communication material exchange. Pyroptosis, death involved innate immunity, also associated many Studies have shown MSC-derived exosomes therapeutic potential range conditions by regulating inflammation pyroptosis. study explored modulating pyroptosis improve bone-related
Language: Английский
Citations
2
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 475, P. 146238 - 146238
Published: Sept. 23, 2023
Language: Английский
Citations
36
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114817 - 114817
Published: May 2, 2023
Cardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem have high morbidity mortality worldwide, as well substantial health economic burdens, representing urgent clinical need. In recent years, the focus of research has shifted from use mesenchymal stem cells (MSCs) for transplantation to their secretory exosomes (MSC-exosomes) treatment numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusion (I/R), aneurysm, stroke. MSCs are pluripotent with multiple differentiation pathways that exert pleiotropic effects by producing soluble factors, most effective components which exosomes. MSC-exosomes considered be excellent promising cell-free therapy CVDs due higher circulating stability, improved biocompatibility, reduced toxicity, immunogenicity. addition, play critical roles in repairing inhibiting apoptosis, regulating inflammation, ameliorating cardiac remodeling, promoting angiogenesis. Herein, we describe knowledge about biological characteristics MSC-exosomes, investigate mechanism mediate therapeutic repair, summarize advances efficacy a view toward future applications.
Language: Английский
Citations
30
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: June 27, 2023
Accumulating evidence indicates that most primary Wharton’s jelly mesenchymal stem cells (WJ-MSCs) therapeutic potential is due to their paracrine activity, i.e., ability modulate microenvironment by releasing bioactive molecules and factors collectively known as secretome. These can either be released directly into the surrounding or embedded within membrane-bound extracellular nano-sized (usually 30–150 nm) messenger particles vesicles of endosomal origin with specific route biogenesis, exosomes carried relatively larger (100 nm–1 μm) formed outward blebbing plasma membrane called microvesicles (MVs); MVs are (EVs). The found in secretome various types, including cytokines, chemokines, cytoskeletal proteins, integrins, growth factors, angiogenic mediators, hormones, metabolites, regulatory nucleic acid molecules. As expected, performs different biological functions, such immunomodulation, tissue replenishment, cellular homeostasis, besides possessing anti-inflammatory anti-fibrotic effects. This review highlights current advances research on WJ-MSCs’ its prospective clinical applications.
Language: Английский
Citations
23
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1597 - 1627
Published: Feb. 1, 2024
Abstract: The development of numerous diseases is significantly influenced by inflammation. Macrophage-derived exosomes (M-Exos) play a role in controlling inflammatory reactions various conditions, including chronic pain, hypertension, and diabetes. However, the specific targets roles M-Exos regulating inflammation remain largely unknown. This review summarizes current knowledge on biogenesis provides updated information M-Exos' biological function modulation. Furthermore, this highlights functionalization engineering strategies M-Exos, while providing an overview cutting-edge approaches to advancements their application as therapeutics for Finally, multiple mechanisms are presented along with perspectives challenges, potential contribution that may have through modulation discussed. Keywords: inflammation, macrophage-derived exosomes, functions, modulation,
Language: Английский
Citations
14
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 19, 2024
In recent years, cell therapy has provided desirable properties for promising new drugs. Mesenchymal stem cells are candidates developing genetic engineering and drug delivery strategies due to their inherent properties, including immune regulation, homing ability tumor tropism. The therapeutic potential of mesenchymal is being investigated cancer therapy, inflammatory fibrotic diseases, among others. attractive cellular carriers synthetic nanoparticles ability. this review, we comprehensively discuss the various non-genetic derivatives in delivery, tissue regeneration other fields. addition, current limitations challenges clinical translation, aiming identify important development areas future directions.
Language: Английский
Citations
12
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 15, 2024
Abstract In recent decades, emerging data have highlighted the critical role of extracellular vesicles (EVs), especially (exosomes) Exos, in progression and development several cancer types. These nano-sized are released by different cell lineages within niche maintain a suitable platform for interchange various signaling molecules paracrine manner. Based on studies, Exos can transfer oncogenic factors to other cells, alter activity immune tumor microenvironment, leading expansion cells metastasis remote sites. It has been indicated that cell-to-cell crosstalk is so complicated wide array involved this process. How which mechanisms regulate behavior non-cancer at center debate. Here, we scrutinize molecular parenchyma. Besides, tumoricidal properties from stem (SC) types discussed detail.
Language: Английский
Citations
9