European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2023, Номер 195, С. 114148 - 114148
Опубликована: Ноя. 22, 2023
Язык: Английский
European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 195, С. 106711 - 106711
Опубликована: Янв. 28, 2024
Methotrexate (MTX) is a first-line drug in treating psoriasis because of its strong anti-proliferation and anti-inflammatory effects. However, systemic administration MTX will lead to many side effects, such as gastrointestinal irritation, liver kidney toxicity, etc. Herein, we developed liposome-loaded microneedles (MNs) system improve transdermal efficiency, which was used overcome the problems low efficiency poor therapeutic effect traditional delivery methods. Hyaluronic acid (HA) modified on surface MTX-loaded liposomes. The interaction HA CD44 could increase adhesion HA-MTX-Lipo HaCaT cells, thereby promoting apoptosis or death cells. Results indicated MNs inhibit development reduce degree skin erythema, scaling, thickening. mRNA levels proinflammatory cytokines IL-17A, IL-23, TNF-α were decreased. epidermal thickness proliferative cell-associated antigen Ki67 expression also reduced. Specifically, down-regulated. HA-modified-MTX liposomes provided promising method for psoriasis.
Язык: Английский
Процитировано
14
Molecular Pharmaceutics, Год журнала: 2024, Номер 21(5), С. 2118 - 2147
Опубликована: Апрель 25, 2024
The various kinds of nanocarriers (NCs) have been explored for the delivery therapeutics designed management skin manifestations. NCs are considered as one promising approaches attributable to sustained release and enhanced penetration. Despite extensive applications NCs, challenges in their via barrier (majorly stratum corneum) persisted. To overcome all associated with microneedle (MN) technology has emerged a beacon hope. Programmable drug release, being painless, its minimally invasive nature make it an intriguing strategy circumvent multiple systems. integration positive traits MNs boosts therapeutic effectiveness by evading corneum, facilitating through enhancing targeted delivery. This review discusses function skin, importance MNs, types superiority NC-loaded MNs. We highlighted NC-integrated ailments, combinational delivery, active targeting, vivo imaging, theranostics. clinical trials, patent portfolio, marketed products drug/NC-integrated covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along prospects needed scale up MN technology, deliberated. current is anticipated deliver thoughtful visions researchers, clinicians, formulation scientists successful development MN-technology-based product carefully optimizing variables.
Язык: Английский
Процитировано
5
Acta Biomaterialia, Год журнала: 2024, Номер 187, С. 20 - 50
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
5
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125423 - 125423
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143089 - 143089
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4061 - 4079
Опубликована: Май 1, 2024
Purpose: Transdermal Drug Delivery System (TDDS) offers a promising alternative for delivering poorly soluble drugs, challenged by the stratum corneum's barrier effect, which restricts pool of drug candidates suitable TDDS. This study aims to establish delivery platform specifically highly lipophilic drugs requiring high doses (log P > 5, dose 10 mg/kg/d), improve their intradermal and enhance solubility. Methods: Cannabidiol (CBD, log = 5.91) served as model drug. A CBD nanosuspension (CBD-NS) was prepared using bottom-up method. The particle size, polydispersity index (PDI), zeta potential, concentration CBD-NS were characterized. Subsequently, incorporated into dissolving microneedles (DMNs) through one-step manufacturing process. dissolution abilities, physicochemical properties, mechanical strength, insertion depth, release behavior DMNs evaluated. Sprague-Dawley (SD) rats utilized assess efficacy DMN patch in treating knee synovitis analyze its skin permeation kinetics pharmacokinetic performance. Results: CBD-NS, stabilized with Tween 80, exhibited size 166.83 ± 3.33 nm, PDI 0.21 0.07, 46.11 0.52 mg/mL. loaded demonstrated favorable properties. It effectively increased skin, extended action's duration vivo, enhanced bioavailability. superior therapeutic safety rat synovitis, significantly inhibiting TNF-α IL-1β compared methotrexate subcutaneous injection Conclusion: NS technology enhances solubility CBD, while facilitates penetration, extends action improves Furthermore, has shown outcomes synovitis. innovative system is expected offer more efficient solution administration akin thereby facilitating high-dose administration. Keywords: nanosuspension, microneedle, cannabidiol,
Язык: Английский
Процитировано
4
Nano Research, Год журнала: 2024, Номер 17(8), С. 7436 - 7448
Опубликована: Май 18, 2024
Язык: Английский
Процитировано
4
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 283 - 283
Опубликована: Фев. 20, 2025
Psoriasis is a chronic inflammatory disease with complex pathogenesis, influenced by various factors involving environment, genes, and immunity. The main symptoms of psoriasis include erythema, scales, itching, etc. At present, therapeutic drugs for are continually evolving towards enhancing treatment efficacy reducing side effects. Firstly, the pathogenesis characteristics were summarized. Then, types benefits topical therapy introduced, such as aspects avoiding systemic toxic effects, first pass effect, gastrointestinal reactions accelerating onset time improving its efficacy, compared to drugs. In case methotrexate, cyclosporin A, Janus kinase (JAK) inhibitors, phosphodiesterase-4 (PDE-4) this review had further discussion on improvement translation these molecules from in clinical practice. To augment limitation skin permeability, nanotechnology novel drug delivery system including nanomedicines, hydrogels, ionic liquids, microneedles elaborated management. Also, exploration targeting pathogenic genes through small interfering RNA (siRNA) using nanoparticles liquids (ILs) great significance long-term psoriasis. Taken together, development numerous platforms expected achieve enhanced penetration, precise efficient molecule interference (RNAi) therapeutics prospects.
Язык: Английский
Процитировано
0