Macromolecular Bioscience,
Год журнала:
2024,
Номер
24(6)
Опубликована: Янв. 24, 2024
Hydrogels
are
3D
networks
swollen
with
water.
They
biocompatible,
strong,
and
moldable
emerging
as
a
promising
biomedical
material
for
regenerative
medicine
tissue
engineering
to
deliver
therapeutic
genes.
The
excellent
natural
extracellular
matrix
simulation
properties
of
hydrogels
enable
them
be
co-cultured
cells
or
enhance
the
expression
viral
non-viral
vectors.
Its
biocompatibility,
high
strength,
degradation
performance
also
make
action
process
carriers
in
tissues
more
ideal,
making
it
an
ideal
material.
It
has
been
shown
that
hydrogel-based
gene
delivery
technologies
have
potential
play
therapy-relevant
roles
organs
such
bone,
cartilage,
nerve,
skin,
reproductive
organs,
liver
animal
experiments
preclinical
trials.
This
paper
reviews
recent
articles
on
explains
manufacture,
applications,
developmental
timeline,
limitations,
future
directions
techniques.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 116008 - 116008
Опубликована: Дек. 9, 2023
The
burden
of
lung
diseases
is
gradually
increasing
with
an
increase
in
the
average
human
life
expectancy.
Therefore,
it
necessary
to
identify
effective
methods
treat
and
reduce
their
social
burden.
Currently,
number
studies
focus
on
role
mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
as
a
cell-free
therapy
diseases.
They
show
great
potential
for
application
more
stable
safer
option
than
traditional
cell
therapies.
MSC-Exos
are
rich
various
substances,
including
proteins,
nucleic
acids,
DNA.
Delivery
Non-coding
RNAs
(ncRNAs)
enables
communicate
target
cells.
significantly
inhibit
inflammatory
factors,
oxidative
stress,
promote
normal
proliferation,
apoptosis
by
delivering
ncRNAs.
Moreover,
carrying
specific
ncRNAs
affect
invasion,
migration
cancer
cells,
thereby
playing
managing
cancer.
detailed
mechanisms
clinical
treatment
disease
were
explored
developing
standardized
culture,
isolation,
purification,
administration
strategies.
In
summary,
MSC-Exo-based
delivery
have
important
prospects
treating
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 19, 2024
Allergic
rhinitis
(AR)
is
a
condition
with
limited
treatment
options.
This
study
investigates
the
potential
use
of
mesenchymal
stem
cell
(MSC)
nanovesicles
as
novel
therapy
for
AR.
Specifically,
explores
underlying
mechanisms
MSC
nanovesicle
by
targeting
dendritic
cells
(DCs).
The
researchers
fabricated
DC-targeted
P-D2-EVs
and
characterized
their
properties.
Transcriptomic
sequencing
single-cell
analyses
were
performed
to
impact
on
AR
mice,
identifying
core
genes
involved
in
treatment.
In
vitro
experiments
conducted
validate
effects
DC
metabolism,
Th2
differentiation,
ILC2
activation.
results
showed
that
efficiently
targeted
DCs.
analysis
revealed
differential
expression
948
nasal
tissue
DCs
mice
treated
P-D2-EVs.
Single-cell
further
had
inhibitory
activation,
Fut1
identified
gene.
Validation
demonstrated
improved
IL10
metabolism
downregulating
expression,
thereby
suppressing
differentiation
Animal
confirmed
ability
ameliorate
symptoms
mice.
suggests
reshape
suppress
activation
through
inhibition
Fut1/ICAM1/P38
MAPK
signaling
pathway,
providing
therapeutic
approach
Macromolecular Bioscience,
Год журнала:
2024,
Номер
24(6)
Опубликована: Янв. 24, 2024
Hydrogels
are
3D
networks
swollen
with
water.
They
biocompatible,
strong,
and
moldable
emerging
as
a
promising
biomedical
material
for
regenerative
medicine
tissue
engineering
to
deliver
therapeutic
genes.
The
excellent
natural
extracellular
matrix
simulation
properties
of
hydrogels
enable
them
be
co-cultured
cells
or
enhance
the
expression
viral
non-viral
vectors.
Its
biocompatibility,
high
strength,
degradation
performance
also
make
action
process
carriers
in
tissues
more
ideal,
making
it
an
ideal
material.
It
has
been
shown
that
hydrogel-based
gene
delivery
technologies
have
potential
play
therapy-relevant
roles
organs
such
bone,
cartilage,
nerve,
skin,
reproductive
organs,
liver
animal
experiments
preclinical
trials.
This
paper
reviews
recent
articles
on
explains
manufacture,
applications,
developmental
timeline,
limitations,
future
directions
techniques.
