Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 3, 2024
Abstract
Modification
of
polylactic
acid
(PLA)
is
a
promising
strategy
for
the
next
generation
bioresorbable
vascular
stent
biomaterials.
With
this
focus,
FeMOFs
nanoparticles
was
incorporated
in
PLA,
and
then
post
loading
carbon
monoxide
(CO)
performed
by
pressurization.
It
showed
incorporation
increased
hydrophilicity
surface
CO
loading,
release
sustained
at
least
3
days.
well
acknowledged
NETosis
macrophage
mediated
inflammation
are
principal
effectors
atherosclerosis
cardiovascular
disease,
it
further
increases
risk
late
thrombosis
restenosis.
In
study,
effects
PLA/FeMOFs/CO
on
behavior
were
thoroughly
explored.
vitro
evaluation
results
that
significantly
inhibited
neutrophil
extracellular
traps
(NETs)
elastase
expression
reducing
intracellular
reactive
oxygen
species
simulated
inflammatory
environment.
reduced
Lipopolysaccharide-induced
with
decreased
tumor
necrosis
factor-α
IL-10
expression.
Meanwhile
enhanced
endothelial
cell
activity
growth
environment,
platelet
adhesion
activation.
vivo
implantation
confirmed
macrophages
neutrophils
response,
thus
neointimal
hyperplasia.
Overall,
effectively
prevented
restenosis
associated
PLA
implantation.
Our
study
provides
new
to
improve
immunocompatibility
implant
materials.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2851 - 2877
Опубликована: Март 1, 2024
Neutrophil
extracellular
traps
(NETs)
are
fibers
composed
of
deoxyribonucleic
acid
(DNA)
and
decorated
proteins
produced
by
neutrophils.
Recently,
NETs
have
been
associated
with
the
development
many
diseases,
including
tumors.
Herein,
we
reviewed
correlation
between
In
addition,
detailed
active
compounds
from
traditional
herbal
medicine
formulations
that
inhibit
NETs,
related
nanodrug
delivery
systems,
antibodies
serve
as
"guiding
moieties"
to
ensure
targeted
NETs.
Furthermore,
discussed
strategies
used
pathogenic
microorganisms
evade
Clinical and Translational Science,
Год журнала:
2024,
Номер
17(5)
Опубликована: Май 1, 2024
To
investigate
the
effects
of
neutrophil
elastase
inhibitor
(sivelestat
sodium)
on
gastrointestinal
function
in
sepsis.
A
reanalysis
data
from
previous
clinical
trials
conducted
at
our
center
was
performed.
Septic
patients
were
divided
into
either
sivelestat
group
or
non-sivelestat
group.
The
dysfunction
score
(GIDS),
feeding
intolerance
(FI)
incidence,
serum
levels
intestinal
barrier
and
inflammatory
biomarkers
recorded.
severity
outcome
variables
also
documented.
total
163
septic
included.
proportion
with
GIDS
≥2
reduced
relative
to
that
(9.6%
vs.
22.5%,
p
=
0.047)
7th
day
intensive
care
unit
(ICU)
admission.
FI
incidence
remarkably
contrast
(21.2%
37.8%,
0.034).
Furthermore,
had
fewer
days
[4
(3,
4)
5
(4-6),
0.008].
d-lactate
(p
0.033),
fatty
acid-binding
protein
0.005),
interleukin-6
0.001),
white
blood
cells
0.007),
C-reactive
procalcitonin
<
0.001)
lower
than
those
demonstrated
longer
ICU-free
[18
(0-22)
13
(0-17),
0.004]
ventilator-free
[22
(1-24)
16
(1-19),
0.002]
compared
In
conclusion,
sodium
administration
appears
improve
dysfunction,
mitigate
dysregulated
inflammation,
reduce
disease
patients.
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1175 - 1175
Опубликована: Сен. 6, 2024
Periodontitis
is
a
chronic
inflammation
caused
by
periodontopathogenic
bacteria
in
the
dental
biofilm,
and
also
involves
inflammatory-immune
response
of
host.
Polymorphonuclear
neutrophils
(PMNs)
play
essential
roles
bacterial
clearance
multiple
mechanisms,
including
formation
neutrophil
extracellular
traps
(NETs)
that
retain
destroy
pathogens.
During
PD
progression,
interaction
between
PMNs,
NETs,
leads
to
an
exaggerated
immune
prolonged
inflammatory
state.
As
lesion
matures,
PMNs
accumulate
periodontal
tissues
die
via
NETosis,
ultimately
resulting
tissue
injury.
A
better
understanding
role
associated
molecules,
pathogenic
pathways
NET
periodontitis,
could
provide
markers
NETosis
as
reliable
diagnostic
prognostic
tools.
Moreover,
assessment
biomarker
levels
biofluids,
particularly
saliva
or
gingival
crevicular
fluid,
be
useful
for
monitoring
periodontitis
progression
treatment
efficacy.
Preventing
excessive
accumulation
tissues,
both
controlling
NETs'
their
appropriate
removal,
key
further
development
more
efficient
therapeutic
approaches.
In
therapy,
local
drug
delivery
(LDD)
systems
are
targeted,
enhancing
bioavailability
active
pharmacological
agents
pocket
surrounding
time
ensure
optimal
outcome.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 3, 2024
Abstract
Modification
of
polylactic
acid
(PLA)
is
a
promising
strategy
for
the
next
generation
bioresorbable
vascular
stent
biomaterials.
With
this
focus,
FeMOFs
nanoparticles
was
incorporated
in
PLA,
and
then
post
loading
carbon
monoxide
(CO)
performed
by
pressurization.
It
showed
incorporation
increased
hydrophilicity
surface
CO
loading,
release
sustained
at
least
3
days.
well
acknowledged
NETosis
macrophage
mediated
inflammation
are
principal
effectors
atherosclerosis
cardiovascular
disease,
it
further
increases
risk
late
thrombosis
restenosis.
In
study,
effects
PLA/FeMOFs/CO
on
behavior
were
thoroughly
explored.
vitro
evaluation
results
that
significantly
inhibited
neutrophil
extracellular
traps
(NETs)
elastase
expression
reducing
intracellular
reactive
oxygen
species
simulated
inflammatory
environment.
reduced
Lipopolysaccharide-induced
with
decreased
tumor
necrosis
factor-α
IL-10
expression.
Meanwhile
enhanced
endothelial
cell
activity
growth
environment,
platelet
adhesion
activation.
vivo
implantation
confirmed
macrophages
neutrophils
response,
thus
neointimal
hyperplasia.
Overall,
effectively
prevented
restenosis
associated
PLA
implantation.
Our
study
provides
new
to
improve
immunocompatibility
implant
materials.
