International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 11957 - 11971
Published: Nov. 1, 2024
Disseminated
intravascular
coagulation
(DIC)
is
an
acquired
disorder
characterized
by
systemic
activation
of
blood
coagulation,
which
can
arise
from
various
causes.
Owing
to
its
abrupt
onset,
rapid
progression,
and
high
mortality
rate,
DIC
presents
a
major
clinical
challenge.
Anticoagulant
drugs,
such
as
heparin
or
low-molecular-weight
heparin,
are
the
current
gold
standard
treatment;
however,
these
interventions
pose
considerable
bleeding
risks.
Thus,
safer
more
effective
therapeutic
strategies
urgently
required.
their
strong
anti-inflammatory
tissue
repair
capabilities,
mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
have
gained
attention
novel
options
for
numerous
disorders,
including
DIC.
Their
stability
in
diverse
pathological
states
highlights
potential
promising
candidates
therapy.
This
review
latest
insights
on
pathogenesis
anticoagulant
properties
MSC-Exos.
We
aimed
elucidate
mechanisms
MSC-Exos
influence
pathogenesis.
speculate
that
offer
multifaceted
approach
treatment
attenuating
neutrophil
extracellular
trap
formation,
modulating
M1/M2
macrophage
polarization,
altering
Nrf2/NF-κB
signalling
pathway
downregulate
pro-inflammatory
factors,
correcting
imbalances
coagulation-fibrinolysis
system
through
routes.
suggests
paradigm
therapy,
offering
targets
modalities
management.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2851 - 2877
Published: March 1, 2024
Neutrophil
extracellular
traps
(NETs)
are
fibers
composed
of
deoxyribonucleic
acid
(DNA)
and
decorated
proteins
produced
by
neutrophils.
Recently,
NETs
have
been
associated
with
the
development
many
diseases,
including
tumors.
Herein,
we
reviewed
correlation
between
In
addition,
detailed
active
compounds
from
traditional
herbal
medicine
formulations
that
inhibit
NETs,
related
nanodrug
delivery
systems,
antibodies
serve
as
"guiding
moieties"
to
ensure
targeted
NETs.
Furthermore,
discussed
strategies
used
pathogenic
microorganisms
evade
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1175 - 1175
Published: Sept. 6, 2024
Periodontitis
is
a
chronic
inflammation
caused
by
periodontopathogenic
bacteria
in
the
dental
biofilm,
and
also
involves
inflammatory-immune
response
of
host.
Polymorphonuclear
neutrophils
(PMNs)
play
essential
roles
bacterial
clearance
multiple
mechanisms,
including
formation
neutrophil
extracellular
traps
(NETs)
that
retain
destroy
pathogens.
During
PD
progression,
interaction
between
PMNs,
NETs,
leads
to
an
exaggerated
immune
prolonged
inflammatory
state.
As
lesion
matures,
PMNs
accumulate
periodontal
tissues
die
via
NETosis,
ultimately
resulting
tissue
injury.
A
better
understanding
role
associated
molecules,
pathogenic
pathways
NET
periodontitis,
could
provide
markers
NETosis
as
reliable
diagnostic
prognostic
tools.
Moreover,
assessment
biomarker
levels
biofluids,
particularly
saliva
or
gingival
crevicular
fluid,
be
useful
for
monitoring
periodontitis
progression
treatment
efficacy.
Preventing
excessive
accumulation
tissues,
both
controlling
NETs'
their
appropriate
removal,
key
further
development
more
efficient
therapeutic
approaches.
In
therapy,
local
drug
delivery
(LDD)
systems
are
targeted,
enhancing
bioavailability
active
pharmacological
agents
pocket
surrounding
time
ensure
optimal
outcome.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
The
aim
of
this
study
was
to
investigate
the
relationship
between
fibroblast
growth
factor
19
(FGF19)
and
prognosis
immune
infiltration
colorectal
cancer
(CRC),
find
related
genes
pathways
affecting
occurrence
development
CRC,
providing
an
important
molecular
basis
for
early
diagnosis
immunotherapy
CRC.
We
performed
Venn
overlap
analysis
on
prognosis-related
CRC
up-regulated
differentially
expressed
(DEGs)
immune-related
gene
sets
obtain
final
DEGs.
investigated
target
pathological
parameters,
infiltration,
checkpoints.
relevant
functions
signaling
were
analyzed
by
enrichment
analysis.
genetic
variation
genes.
association
with
tumor
heterogeneity
drug
sensitivity.
Finally,
we
single-cell
results
indicate
that
FGF19
is
a
associated
immunity
in
patients.
By
exploring
neutrophil
extracellular
traps
(NETs),
NETs
microenvironment,
found
may
have
effect
progression
promoting
expression
leading
cell
suppression.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 11957 - 11971
Published: Nov. 1, 2024
Disseminated
intravascular
coagulation
(DIC)
is
an
acquired
disorder
characterized
by
systemic
activation
of
blood
coagulation,
which
can
arise
from
various
causes.
Owing
to
its
abrupt
onset,
rapid
progression,
and
high
mortality
rate,
DIC
presents
a
major
clinical
challenge.
Anticoagulant
drugs,
such
as
heparin
or
low-molecular-weight
heparin,
are
the
current
gold
standard
treatment;
however,
these
interventions
pose
considerable
bleeding
risks.
Thus,
safer
more
effective
therapeutic
strategies
urgently
required.
their
strong
anti-inflammatory
tissue
repair
capabilities,
mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
have
gained
attention
novel
options
for
numerous
disorders,
including
DIC.
Their
stability
in
diverse
pathological
states
highlights
potential
promising
candidates
therapy.
This
review
latest
insights
on
pathogenesis
anticoagulant
properties
MSC-Exos.
We
aimed
elucidate
mechanisms
MSC-Exos
influence
pathogenesis.
speculate
that
offer
multifaceted
approach
treatment
attenuating
neutrophil
extracellular
trap
formation,
modulating
M1/M2
macrophage
polarization,
altering
Nrf2/NF-κB
signalling
pathway
downregulate
pro-inflammatory
factors,
correcting
imbalances
coagulation-fibrinolysis
system
through
routes.
suggests
paradigm
therapy,
offering
targets
modalities
management.
