East European Journal of Physics,
Год журнала:
2025,
Номер
1, С. 376 - 382
Опубликована: Март 3, 2025
This
study
explores
the
development
of
advanced
protein-based
drug
delivery
systems
for
doxorubicin
(DOX),
an
anticancer
agent,
incorporating
both
radionuclide
(technetium-99m
complexes)
and
fluorescence
(Methylene
Blue
(MB),
Indocyanine
Green
(IG),
cyanine
AK7-5
squaraine
SQ1)
imaging
modalities.
Building
upon
previous
research
on
albumin-based
carriers,
this
work
expands
scope
by
introducing
transferrin
(TRF)
as
a
complementary
protein
component
to
create
more
sophisticated
targeted
platform.
Molecular
docking
technique
was
employed
design
characterize
multimodal
that
incorporate
radiopharmaceuticals
near-infrared
fluorescent
dyes.
The
results
demonstrate
technetium-99m-based
are
capable
strong
noncovalent
binding
human
serum
albumin
(HSA)
its
complexes
with
transferrin.
A
comprehensive
analysis
scores
interacting
amino
acid
residues
reveals
HSA-TRF-TcHyn/TcMEB/TcDIS-DOX-IG/SQ1
show
highest
potential
experimental
testing
further
development.
These
findings
support
HSA-TRF
nanocarriers
dual
capabilities
DOX
delivery,
offering
approach
enhance
therapeutic
efficacy
while
reducing
systemic
toxicity
in
treatment.
Polymers,
Год журнала:
2024,
Номер
16(17), С. 2536 - 2536
Опубликована: Сен. 7, 2024
In
the
last
few
decades,
there
has
been
a
growing
interest
in
use
of
biodegradable
polymeric
nanoparticles
(BPNPs)
as
carriers
for
various
therapeutic
agents
drug
delivery
systems.
BPNPs
have
potential
to
improve
efficacy
numerous
active
by
facilitating
targeted
desired
site
body.
Biodegradable
polymers
are
especially
promising
nanocarriers
substances
characterized
poor
solubility,
instability,
rapid
metabolism,
and
system
elimination.
Such
molecules
can
be
efficiently
encapsulated
subsequently
released
from
nanoparticles,
which
greatly
improves
their
stability
bioavailability.
Biopolymers
seem
most
suitable
candidates
used
platforms,
due
biocompatibility
biodegradability.
Other
unique
properties
include
low
cost,
flexibility,
stability,
minimal
side
effects,
toxicity,
good
entrapment
potential,
long-term
controlled
release.
An
overview
summarizing
research
results
years
field
successful
fabrication
loaded
with
is
provided.
The
possible
challenges
involving
nanoparticle
under
physiological
conditions
possibility
scaling
up
production
while
maintaining
quality,
well
future
possibilities
employing
BPNPs,
also
reviewed.
Biomarker Research,
Год журнала:
2024,
Номер
12(1)
Опубликована: Ноя. 13, 2024
Lung
cancer
leads
in
causing
cancer-related
mortality
worldwide,
continually
posing
a
significant
threat
to
human
health.
Current
imaging
diagnostic
techniques,
while
offering
non-invasive
detection,
suffer
from
issues
such
as
insufficient
sensitivity
and
the
risks
associated
with
radiation
exposure.
Pathological
diagnosis,
gold
standard
for
confirmation,
also
faces
challenges
like
invasiveness
high
costs.
In
treatment,
surgery,
radiotherapy,
chemotherapy
are
main
modalities,
each
encountering
related
precision,
environmental
adaptability,
side
effects.
Nanotechnology's
advancement
provides
new
solutions
diagnosis
treatment
of
lung
cancer,
promising
enhance
accuracy
reduce
effects
during
treatment.
This
article
introduces
types
nanomaterials
used
field
comprehensive
overview
current
research
on
application
nanotechnology
early
screening,
monitoring
summarizing
ongoing
clinical
findings.
ACS Omega,
Год журнала:
2024,
Номер
9(42), С. 42613 - 42629
Опубликована: Окт. 10, 2024
Nanomedicine
enables
advanced
therapeutics,
diagnostics,
and
predictive
analysis,
enhancing
treatment
outcomes
patient
care.
The
choices
development
of
high-quality
organic
nanoparticles
with
relatively
lower
toxicity
are
important
for
achieving
medical
goals.
Among
molecules,
proteins
have
been
prospected
as
smart
candidates
to
revolutionize
nanomedicine
due
their
inherent
fascinating
features.
advent
protein
nanoarchitectures,
which
explore
the
biomolecular
corona,
offers
new
insights
into
efficient
tissue
penetration
therapeutic
potential.
This
review
examines
various
animal-
plant-based
nanoparticles,
highlighting
source,
activity,
products,
unique
biomedical
applications
in
regenerative
medicine,
targeted
therapies,
gene
drug
delivery,
antimicrobial
bioimaging,
immunological
adjuvants,
etc.
It
provides
an
extensive
discussion
on
recent
across
diverse
fields
well
evolving
landscape
other
nanoproducts
nanodevices
sensitive
procedures.
Furthermore,
this
introduces
different
preparation
technologies
emphasizing
how
design
construction
significantly
influence
loading
capacity,
stability,
targeting
effects.
Additionally,
we
delve
user-friendly
multifunctional
modular
bioarchitectures
by
assembly
(PNPs),
marking
a
significant
breakthrough
therapies.
also
considers
challenges
synthetic
nanomaterials
emergence
natural
alternatives,
nanoparticle
research.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 172 - 172
Опубликована: Март 4, 2025
Chemotherapy
for
cancer
frequently
uses
platinum-based
medications,
including
oxaliplatin,
carboplatin,
and
cisplatin;
however,
due
to
their
high
systemic
toxicity,
lack
of
selectivity,
drug
resistance,
other
side
effects,
medications
have
very
limited
clinical
application.
As
a
first-line
medication
in
antitumor
therapy,
oxaliplatin
must
be
administered
minimize
effects
while
achieving
anticancer
objectives.
A
new
CDC7
inhibitor
called
XL413
has
demonstrated
promising
therapeutic
variety
malignant
tumors
may
properties.
This
offers
fresh
viewpoint
on
how
lessen
resistance
and,
specifically,
increase
the
potency
already
prescribed
therapies.
In
this
paper,
current
developments
therapy
are
discussed,
along
with
many
mechanisms
oxaliplatin’s
treatment
challenges,
related
approaches.
We
conducted
more
research
that
arose
during
chemotherapy
searched
ways
it
order
enhance
its
chemotherapeutic
performance.
Ultimately,
we
studied
distinct
routes
relate
one
another.
Meanwhile,
XL413,
novel
inhibitor,
perspective
possibilities
developing
approaches
innovation
point.
The
search
terms
“Oxaliplatin,
treatment,”
etc.,
were
applied
X-MOL
PubMed
databases
review’s
literature
search.
Boolean
logic
was
then
employed
maximize
approach.
These
can
offer
thorough
data
cover
broad
range
biological
publications.
Excluded
publications
works
low
relevance,
duplicates,
or
those
insufficient
information.
mechanism
effect,
amelioration,
role
main
topics
140
ultimately
included
analysis.
