HIG-2 promotes glioma stemness and radioresistance mediated by IGFBP2-rich microparticles in hypoxia DOI
Ying Yang, Ting Sun,

Xuefei Xue

и другие.

APOPTOSIS, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Язык: Английский

Glioblastoma- derived exosomes (GBM-Exo) regulate microglial M2 polarization via the RAC1/AKT/NRF2 pathway DOI
Qionghui Wu, Shanlin Chen, Xiaodong Xie

и другие.

Journal of Neuro-Oncology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

0
FSTL3 promotes colorectal cancer by activating the HIF1 pathway DOI

Xiangrong Luo,

Lihui Huang,

Jie Yin

и другие.

Gene, Год журнала: 2025, Номер unknown, С. 149435 - 149435

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Extracellular vesicles as the common denominator among the 7 Rs of radiobiology: From the cellular level to clinical practice DOI
Júlia Oliveira Dias,

Igor Sampaio Fagundes,

Mariana de Cássia Bisio

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189315 - 189315

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Unraveling the therapeutic landscape of miRNAs in pancreatic cancer DOI
Zeinab A. El‐Moaty,

Maria Wagdy Wasef,

Y. A. Elsayed

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Язык: Английский

Процитировано

0
Hypoxia studies in non‑small cell lung cancer: Pathogenesis and clinical implications (Review) DOI Creative Commons
Sirui Zhou, Jiazheng Sun, Weijian Zhu

и другие.

Oncology Reports, Год журнала: 2024, Номер 53(2)

Опубликована: Дек. 30, 2024

Язык: Английский

Процитировано

3
miR-210 Mediated Hypoxic Responses in Pancreatic Ductal Adenocarcinoma DOI Creative Commons
Maria Mortoglou,

Mutian Lian,

Francesc Miralles

и другие.

ACS Omega, Год журнала: 2024, Номер 9(48), С. 47872 - 47883

Опубликована: Ноя. 20, 2024

Pancreatic ductal adenocarcinoma (PDAC) is one among the most lethal malignancies due to its aggressive behavior and resistance conventional therapies. Hypoxia significantly contributes cancer progression therapeutic of PDAC. microRNAs (miRNAs/miRs) have emerged as critical regulators various biological processes. miR-210 known "hypoxamir" prominent role in cellular responses hypoxia. In this study, we investigated multifaceted PDAC using knockout (KO) models elucidate functions under hypoxic conditions. Hypoxia-inducible factor-1α (HIF1-α), a key transcription factor activated response low oxygen levels, upregulates miR-210. maintains stem cell (CSC) phenotypes promotes epithelial-mesenchymal transition (EMT), which essential for tumor initiation, metastasis, resistance. Our findings demonstrate that regulates expression CSC markers, such CD24, CD44, CD133, EMT including E-cadherin, Vimentin, Snail. Specifically, depletion reversed marker levels Panc-1 MiaPaCa-2 cells. These regulatory actions facilitate more invasive treatment-resistant phenotype. Understanding network involving conditions may reveal new targets combating improving patient outcomes. data suggest regulator HIF1-α expression, EMT, stemness cells environments.

Язык: Английский

Процитировано

2
The possible role of hypoxia-induced exosomes on the fibroblast metabolism in idiopathic pulmonary fibrosis DOI Open Access
Noé Alvarado‐Vásquez, Claudia Rangel‐Escareño,

Javier de Jesús Ramos-Abundis

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 181, С. 117680 - 117680

Опубликована: Ноя. 16, 2024

Язык: Английский

Процитировано

1
HIG-2 promotes glioma stemness and radioresistance mediated by IGFBP2-rich microparticles in hypoxia DOI
Ying Yang, Ting Sun,

Xuefei Xue

и другие.

APOPTOSIS, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Язык: Английский

Процитировано

0