HIG-2 promotes glioma stemness and radioresistance mediated by IGFBP2-rich microparticles in hypoxia DOI
Ying Yang, Ting Sun,

Xuefei Xue

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

Glioblastoma- derived exosomes (GBM-Exo) regulate microglial M2 polarization via the RAC1/AKT/NRF2 pathway DOI
Qionghui Wu, Shanlin Chen, Xiaodong Xie

et al.

Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

Citations

0
FSTL3 promotes colorectal cancer by activating the HIF1 pathway DOI

Xiangrong Luo,

Lihui Huang,

Jie Yin

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149435 - 149435

Published: March 1, 2025

Language: Английский

Citations

0
Extracellular vesicles as the common denominator among the 7 Rs of radiobiology: From the cellular level to clinical practice DOI
Júlia Oliveira Dias,

Igor Sampaio Fagundes,

Mariana de Cássia Bisio

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189315 - 189315

Published: April 1, 2025

Language: Английский

Citations

0
Hypoxia studies in non‑small cell lung cancer: Pathogenesis and clinical implications (Review) DOI Creative Commons
Sirui Zhou, Jiazheng Sun, Weijian Zhu

et al.

Oncology Reports, Journal Year: 2024, Volume and Issue: 53(2)

Published: Dec. 30, 2024

Language: Английский

Citations

3
miR-210 Mediated Hypoxic Responses in Pancreatic Ductal Adenocarcinoma DOI Creative Commons
Maria Mortoglou,

Mutian Lian,

Francesc Miralles

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(48), P. 47872 - 47883

Published: Nov. 20, 2024

Pancreatic ductal adenocarcinoma (PDAC) is one among the most lethal malignancies due to its aggressive behavior and resistance conventional therapies. Hypoxia significantly contributes cancer progression therapeutic of PDAC. microRNAs (miRNAs/miRs) have emerged as critical regulators various biological processes. miR-210 known "hypoxamir" prominent role in cellular responses hypoxia. In this study, we investigated multifaceted PDAC using knockout (KO) models elucidate functions under hypoxic conditions. Hypoxia-inducible factor-1α (HIF1-α), a key transcription factor activated response low oxygen levels, upregulates miR-210. maintains stem cell (CSC) phenotypes promotes epithelial-mesenchymal transition (EMT), which essential for tumor initiation, metastasis, resistance. Our findings demonstrate that regulates expression CSC markers, such CD24, CD44, CD133, EMT including E-cadherin, Vimentin, Snail. Specifically, depletion reversed marker levels Panc-1 MiaPaCa-2 cells. These regulatory actions facilitate more invasive treatment-resistant phenotype. Understanding network involving conditions may reveal new targets combating improving patient outcomes. data suggest regulator HIF1-α expression, EMT, stemness cells environments.

Language: Английский

Citations

2
The possible role of hypoxia-induced exosomes on the fibroblast metabolism in idiopathic pulmonary fibrosis DOI Open Access
Noé Alvarado‐Vásquez, Claudia Rangel‐Escareño,

Javier de Jesús Ramos-Abundis

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117680 - 117680

Published: Nov. 16, 2024

Language: Английский

Citations

1
HIG-2 promotes glioma stemness and radioresistance mediated by IGFBP2-rich microparticles in hypoxia DOI
Ying Yang, Ting Sun,

Xuefei Xue

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

Citations

0