Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review

ACS Omega, Год журнала: 2023, Номер 8(39), С. 35452 - 35469

Опубликована: Сен. 19, 2023

Pomegranate peel, derived from the processing of Punica granatum L. (pomegranate), has traditionally been considered agricultural waste. However, recent studies have revealed its potential as a rich source bioactive compounds with diverse pharmacological effects. peel is reservoir antioxidants, polyphenols, dietary fiber, and vitamins, which contribute to remarkable bioactivity. Studies demonstrated anti-inflammatory, cardioprotective, wound healing, anticancer, antimicrobial properties pomegranate owing presence phytochemicals, such gallic acid, ellagic punicalagin. The extraction requires careful selection techniques maximize yield quality. Green methods, including pressurized liquid (PLE), ultrasound-assisted (UAE), microwave-assisted (MAE), enzyme-assisted (EAE), offer efficient sustainable alternatives traditional methods. Furthermore, utilized in food industry, where it can significantly enhance nutritional value, organoleptic characteristics, shelf life products. be used develop innovative functional foods, nutraceuticals, other value-added products, providing new opportunities for pharmaceutical, cosmetic, industries.

Язык: Английский

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Pomegranate (Punica granatum L.) phytochemicals target the components of metabolic syndrome

The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 131, С. 109670 - 109670

Опубликована: Май 19, 2024

Язык: Английский

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Pomegranate peel: Bioactivities as antimicrobial and cytotoxic agents

Food Science & Nutrition, Год журнала: 2024, Номер 12(4), С. 2818 - 2832

Опубликована: Март 5, 2024

Abstract This is a comparative study to evaluate the effectiveness of six pomegranate peel extracts (PPEs) as antibacterial and antiproliferative agents. The Six PPEs were prepared using four solvent systems each filtrate was concentrated gummy material be used in evaluation. well‐diffusion method their antimicrobial activity against bacteria typically associated with food spoilage: Escherichia coli , Pseudomonas aeruginosa Salmonella typhimurium Listeria monocytogenes Staphylococcus epidermidis aureus three Bacillus species . 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium (MTT) cytotoxicity colorectal carcinoma cells (HCT116), prostate adenocarcinoma (PC3), ovarian cancer (SKOV‐3), fibroblasts (MRC‐5). antioxidant evaluation done 2,2‐diphenyl‐1‐picrylhydrazyl‐hydrate (DPPH) assay. pH water‐containing acidic almost same over 6 weeks. inhibited bacterial growth comparable level standard antibiotics. extract dependent on strain, showed remarkable inhibition when exposed aqueous at room temperature (RT). (RT) methanol had significant scavenging capability cytotoxic PC3 half maximal inhibitory concentration (IC 50 ) 0.1 μg/mL. boiled exhibited HCT116 an IC 21.45 effect SKOV‐3 insignificant. With exception butanol, screening shows inverse correlation between polarity extraction IC50 by PPEs. variation suggested due variable soluble bioactive compounds that may interact differently different cells, though are promising findings clearly show possessed potential eco‐friendly novel source for natural can implemented industry additive prevent foodborne illnesses.

Язык: Английский

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Spatial metabolomics and feature-based molecular networking to unveiling in-situ quality markers landscape and reflecting geographic origins of pomegranate seeds

Food Chemistry, Год журнала: 2025, Номер unknown, С. 142761 - 142761

Опубликована: Янв. 1, 2025

Язык: Английский

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Pomegranate seeds: a comprehensive review of traditional uses, chemical composition, and pharmacological properties

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 11, 2024

Pomegranate seeds (PS) are the dried derived from pomegranate fruit, accounting for approximately 20% of fruit’s total weight, and a by-product juice extraction. These hold significance in traditional medicine among Uyghurs Tibetan cultures, featuring diverse clinical applications within Chinese medicine. include management gastric coldness acidity, abdominal distension, liver gallbladder fever, pediatric enteritis. PS demonstrates properties such as stomach tonicity, qi regulation, analgesia, anti-inflammatory effects. Extensive research underscores richness various phytochemical compounds metabolites, notably unsaturated fatty acids (particularly linolenic acid linoleic acid), phenolic tocopherols, proteins, volatile oils. Notably, these bioactive compounds, punicic (PA), found PS, potential prevention treatment cancers, diabetes, obesity, other ailments. Despite extensive literature on botanical entity, comprehensive review focusing specifically chemical composition pharmacological effects remains elusive. Therefore, this aimed to consolidate knowledge regarding medicinal summarizing its composition, uses, treating diseases, thereby laying foundation advancement application field pharmacology.

Язык: Английский

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Exploring Punicalagin Potential Against Cancers: A Comprehensive Review

Food Science & Nutrition, Год журнала: 2025, Номер 13(3)

Опубликована: Фев. 27, 2025

Punicalagin, being a bioactive polyphenol, has gained significant interest owing to its potential anticancer effects. Researchers are studying punicalagin determine ability inhibit cancer cell proliferation. This paper focuses on highlighting the therapeutic of against tumors and cancers. Punicalagin inhibits tumor growth within body through various cellular pathway interactions. compound effectively eliminates cells from liver, stomach, prostate, lungs. Different animal model studies have demonstrated in blocking MAPK/ERK PI3K/AKT/mTOR signaling pathways, fighting cancer. Through inhibition division, may be capable eradicating breast cells. strongly activities vascular endothelial factor (VEGF), matrix metalloproteinase-9 (MMP-9), uPA. androgen receptor (AR), protein essential for development metastasis prostate Lung can eliminated by initiating caspase cascade inhibiting synthesis, which is facilitated punicalagin. In numerous models, significantly reduces metastasis. Cyclokinase B1 cyclin-dependent kinase 2 promote colon cancer; when reach G2/M phase, induces apoptosis action these proteins. propagation blood vessel There still need further clinical trials fully reveal punicalagin's as well safety; despite fact that it decrease threat increasing provide an alternative treatment many

Язык: Английский

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Laser Ablation-Generated Crystalline Selenium Nanoparticles Prevent Damage of DNA and Proteins Induced by Reactive Oxygen Species and Protect Mice against Injuries Caused by Radiation-Induced Oxidative Stress

Materials, Год журнала: 2023, Номер 16(14), С. 5164 - 5164

Опубликована: Июль 22, 2023

With the help of laser ablation, a technology for obtaining nanosized crystalline selenium particles (SeNPs) has been created. The SeNPs do not exhibit significant toxic properties, in contrast to molecular compounds. administration can significantly increase viabilities SH-SY5Y and PCMF cells after radiation exposure. introduction such nanoparticles into animal body protects proteins DNA from radiation-induced damage. number chromosomal breaks oxidized decreases irradiated mice treated with SeNPs. Using hematological tests, it was found that decrease leukopenia thrombocytopenia is observed when are injected before exposure ionizing radiation. animals 5 h sublethal lethal doses increases their survival rate. modification dose factor 1.2. It shown normalizes gene expression red bone marrow Thus, demonstrated new gene-protective radioprotective agent reduce harmful effects

Язык: Английский

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The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

Molecules, Год журнала: 2023, Номер 28(14), С. 5543 - 5543

Опубликована: Июль 20, 2023

Colon cancer is one of the most common types worldwide, and its incidence increasing. Despite advances in medical science, treatment colon still poses a significant challenge. This study aimed to investigate potential protective effects Adiantum pedatum (AP) extract and/or piceatannol on induced via phenylhydrazine (PHZ) terms antioxidant apoptotic pathways histopathologic changes colons male albino rats. The rats were randomly divided into eight groups: control, AP extract, (P), PHZ, PHZ treatments, P both P, prophylaxis with P. results demonstrated that oxidative damage, apoptosis, histopathological compared control group. However, administration or + as therapy significantly ameliorated these upregulated colonic mir-145 mRNA expression P53 PDCD-4 while downregulating PI3K, AKT, c-Myc, CK-20, SOX-2, OCT-4, NanoG These findings suggest candidate drugs may exert their anti-cancer through multiple mechanisms, including activities.

Язык: Английский

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Unlocking the Bioactive Potential of Pomegranate Peels: A Green Extraction Approach

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1796 - 1796

Опубликована: Сен. 23, 2023

Pomegranate (Punica granatum L.) is well known for its high content of bioactives, including polyphenols, flavonoids, and tannins, which have been shown to exhibit a wide range biological activities, such as antioxidant, antimicrobial, anticancer effects. It worth noting that the majority these molecules are found in peels, usually disposed after processing, causing significant amount waste, amounting more than 3.6 million t/y. This work investigates microwave-assisted extraction (MAE) water recovery antioxidants from pomegranate peels (PP), optimisation temperature times. The total phenolic, anthocyanin, flavonoid, tannin contents recovered extracts were determined, their antioxidant be 356.35 mgGAE/gExtr, 303.97 µgCy3G/gExtr, 37.28 mgQE/gExtr, 56.48 5.72 mmolTE/gExtr, respectively (according adopted reference). All results compared with those obtained using conventional protocol. In addition, potential recycling by means downstream nanofiltration optimised MAE was investigated, leading overall reuse approx. 75%. Power consumption (20.92 W/mgGAE) common green metrics, Reaction Mass Efficiency (RME), E-Factor, Process Intensiti/efficiency (PMI, PME), considered evaluating proposed PP valorisation strategy. Finally, activities main products assessed. antimicrobial properties against three Gram-positive Gram-negative bacteria antiproliferative activity towards human cancer cells tested. S. aureus most susceptible extracts. tested displayed HeLa when higher concentrations tested, D-PP/NF (obtained dried sequential nanofiltration) being effective. result also confirmed via clonogenic analysis, generally indicated possible anti-cancer peel this approach.

Язык: Английский

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Adiantum pedatum as anticancer, anti-oxidant and anti-inflammatory agent

Bulletin of Faculty of Science Zagazig University, Год журнала: 2024, Номер 2023(4), С. 158 - 164

Опубликована: Янв. 1, 2024

Natural products are potential sources for the development of effective and safe anticancer substances.The emergence therapeutic agents derived from natural has reignited global interest encouraged scientists to reconsider medicinal plant research as a viable scientific option diseases treatment.The compounds such flavonoids, polyphenols, or terpenoids cancer prevention been widely investigated.Experimental evidences confirmed that Genus Adiantum (Pteridaceae) is known maidenhair ferns have used medicinally in different parts world.They exhibit antidysenteric, antiulcer, antimicrobial, antitumor, antiviral anti-inflammatory activities.Among these ferns, Adiantumpedatum was found antioxidant anti-microbial activity.

Язык: Английский

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