Advances in Clinical Medicine, Год журнала: 2023, Номер 13(05), С. 7746 - 7753
Опубликована: Янв. 1, 2023
Язык: Английский
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Pediatric Nephrology, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Abstract
Background
The
aim
of
this
study
was
to
compare
the
oral
health
findings
and
salivary
parameters
children
with
different
stages
chronic
kidney
disease
(CKD)
those
healthy
peers.
Methods
Intraoral
examinations
were
performed
on
43
aged
8–17
years
CKD
40
controls
from
same
pediatric
nephrology
clinic.
Oral
assessed
using
DMFT/dft
indices
(decayed-missing-filled-teeth),
debris
index
(DI),
calculus
(CI),
simplified
hygiene
(OHI-S).
Saliva
samples
analyzed
for
flow
rate
(SFR),
pH,
buffering
capacity
(BC),
total
oxidant
status
(TOS),
antioxidant
(TAOC),
urea,
creatinine
(Cr),
calcium
(Ca),
potassium
(K),
phosphorus
(P),
α-amylase
(SAA).
Spearman’s
rho
coefficient
used
examine
relationship
between
serum
biomarkers
levels
findings.
Results
While
scores
lower
in
(
p
=
0.001),
DI,
CI,
OHI-S
higher
peers
<
0.001).
Children
had
SFR,
Ca,
TAOC
levels,
BC,
Cr,
K,
P,
TOS,
SAA
0.001)
compared
controls.
Later
associated
dft
$${r}_{s}$$
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 12, 2025
Язык: Английский
Процитировано
0
PLoS ONE, Год журнала: 2024, Номер 19(10), С. e0310787 - e0310787
Опубликована: Окт. 31, 2024
Heat stress (HS) exerts detrimental effects on animal production, with lactating sows being particularly vulnerable. Understanding the mechanisms involved in HS response could aid developing effective strategies against negative impacts livestock. Recent genome wide association studies identified two core circadian clock genes as potential candidates mediating response. The study aimed to investigate how cooling under natural heat conditions impacted patterns of respiration rate (RR), rectal temperature (RT), behavior, salivary melatonin and cortisol levels, diurnal cytokines saliva. Mixed parity were assigned one treatment groups: electronic pad (C; n = 9) heat-stressed (H; 9). experiment spanned 48 h periods elevated ambient temperatures due summer wave. In first period, RR was recorded every 30 min, RT 60 behaviors (eating, standing, sitting, laying, sleeping, drinking, nursing) 5 min. second saliva samples collected 4 h. Cooling reduced altered (P < 0.05). did not affect amount time engaged any behavior over period > 0.05), however, daily eating, standing laying differed between treatments eating related increment H increased pattern also influenced cytokines. had no impact levels. conclusion, rhythms physiology supporting need for further research understand if disruption underlies decreased production efficiency animals.
Язык: Английский
Процитировано
2
Pediatric Health Medicine and Therapeutics, Год журнала: 2024, Номер Volume 15, С. 95 - 102
Опубликована: Фев. 1, 2024
Aim: Saliva contains various proteins that are important in developing inflammatory processes and their prevention. One key aspect of saliva research is the relationship between oral infections inflammation, role some salivary proteins. The Work Aims: To demonstrate which cytokines can be biomarkers acute odontogenic facial children. Material Methods: study included two groups patients: a group 28 children: 7 girls 21 boys aged 3 − 17 years with dentofacial inflammation (DI) control 52 16 36 4– uncomplicated dental caries (CE). levels Interleukin-5 (IL-5), Interleukin 10 (IL-10), Interleukin-17A (IL-17A), Interleukin-12p70 (IL-12p70), Eotaxin, Rantes, Vascular Endothelial Growth Factor (VEGF), Interferon gamma-induced protein (IP10) children DI CE were compared. Statistical analysis was performed Statistica 13. Student's t -test Wilcoxon signed-rank test used. Results: results show IL-10, IL-17A, Eotaxin showed statistically significant increase compared to group. significance level for IL-10 p=0.02, IL-17A equal p=0.04. other measured parameters did not differ groups. Conclusion: used as potential tooth-related states cavity face These useful identifying monitoring presence face. Keywords: chemokines,
Язык: Английский
Процитировано
1
Ahram Canadian Dental Journal, Год журнала: 2024, Номер 3(1), С. 42 - 54
Опубликована: Янв. 1, 2024
Chronic kidney disease occurs due to a progressive and irreversible decline in the total number of functioning nephrons, which causes glomerular filtration rate. It is considered major public health problem affecting young population with rapidly increasing global burden. Children suffering from chronic have many oral manifestations resulting medical condition itself, type treatment administered, or both. Oral include uremic odor, stomatitis, glossitis, gingival enlargement secondary drug therapy. Other enamel hypoplasia, increased dental calculus deposition, xerostomia. care important management CKD. Negligence children CKD poor awareness among personnel leads quality life for these children. This article reviews guide dentists their patients. Treatment planning should be done after consultation nephrologists regarding specific precautions each patient.
Язык: Английский
Процитировано
1
Starch - Stärke, Год журнала: 2024, Номер unknown
Опубликована: Апрель 25, 2024
Abstract Alpha‐amylase is one of the most important enzymes in saliva. It an biomarker for many health conditions. Saliva sampling a non‐invasive method and preferred choice at point care home testing. Measurement salivary alpha‐amylase activity as rapid test using strips with Flavin‐dependent glucose dehydrogenases (FAD‐GDH) aim current research. FAD‐GDH oxygen‐independent enzyme has narrow substrate specificity. For this goal, starches from various sources are tested chose MS‐101 starch best substrate, between six different types. Under optimal assay conditions, when hydrolyzed (in 20 min, 37 °C, pH = 7) reacts that exist 5 s glucometer can show amount produced samples patient samples. This value directly correlated ( p ‐value <0.01).
Язык: Английский
Процитировано
1
Medical Science Monitor, Год журнала: 2023, Номер 29
Опубликована: Окт. 26, 2023
Background:Ischemia-modified albumin (IMA) is a secreted biomarker for ischemic oxidative stress.This case-control study aimed to evaluate the association of ischemia-modified in saliva, serum, and urine with diagnosis chronic kidney disease (CKD) 24 children. Material/Methods:The involved children CKD.CKD was defined according Kidney Disease Improving Global Outcomes (KDIGO) diagnostic criteria.The control group consisted healthy who were matched age gender experimental group.The concentration IMA determined by colorimetric method non-stimulated whole saliva (NWS), stimulated (SWS), CKD.The Mann-Whitney U test used inter-group comparisons. Results:IMA levels significantly higher NWS (P=0.0082) SWS (P=0.0014) CKD than correlated standard indicators function, including estimated glomerular filtration rate (r=-0.798,P£0.0001), stage (r=0.814,P£0.0001), serum creatinine (r=0.711,P£0.0001) urea (r=0.738,P£0.0001). Conclusions:Salivary depends on renal function children.Salivary discriminates endstage from mild moderate high sensitivity specificity.Further research required, assessment usefulness validation clinical study.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8680 - 8680
Опубликована: Авг. 9, 2024
Dentofacial inflammation resulting from untreated dental caries is a serious disease that can spread to deeper tissues of the neck and face. This study aimed analyze salivary cytokine profiles as potential biomarkers acute odontogenic infections in children. The group consisted 28 children aged 3–17 years old with dentofacial (DI) control (caries experience, CE) 52 4–17 uncomplicated caries. profile was analyzed using Bio-Plex Pro Human Cytokine 27-Plex kit saliva both groups. levels IL-4, IL-15, FGF-2, G-CSF, PDGF-BB were significantly increased compared group. In contrast, other cytokines, such IL-2, IL-7, IL-9, IL-13, GM-CSF, IFN-γ, did not show statistically significant differences between these two may serve selective oral cavity These be useful identifying monitoring progress treatment bacterial inflammation.
Язык: Английский
Процитировано
0
Translational Animal Science, Год журнала: 2024, Номер 9
Опубликована: Ноя. 13, 2024
Abstract Heat stress (HS) poses a significant challenge to the United States swine industry. Sows and their piglets are particularly vulnerable HS, as periparturient phase is characterized by heightened metabolism increased oxidative inflammation. The study examined effects of using conductive electronic cooling pads (ECP) dietary supplementation with 4% Moringa (M) leaf powder on controlling inflammation caused HS in sows piglets. Forty-eight late gestation were assigned four treatment groups: HS-fed corn–soybean meal (HS + CS), ECP-fed (ECP M, ECP M. Blood was collected from (G) day 112, lactation (L) 14 L20, (2 males 2 females) each litter postnatal (PN) 1 PN20. Colostrum within 2h birth first neonate, mature milk L14. Piglet fecal samples PN14 measure calprotectin concentration marker intestinal Biological antioxidant potential (BAP), derivatives reactive oxygen metabolites (dROMs). index (OSi) measured blood Free Radical Elective Evaluator. Milk pooled group analyzed cytokine array. Levels inflammatory cytokines colostrum affected cooling, but not milk. Notably, anti-inflammatory interleukin (IL)-10 IL-1ra 2.14 1.57 Log2 higher M compared other groups. OSi (P = 0.0002) than Level BAP sow serum greater CS 0.0291) had an overall effect increasing dROMs 0.0035) levels lowest 0.0296) serum. Treatments did affect piglet > 0.05) or 0.05). Findings support further studies investigate efficacy mitigate imposed heat conditions lactating sows.
Язык: Английский
Процитировано
0