Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis
Journal of Cardiothoracic Surgery,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 23, 2025
Язык: Английский
miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2
Archives of Virology,
Год журнала:
2024,
Номер
169(5)
Опубликована: Апрель 2, 2024
Язык: Английский
The potential of circulating microRNAs as novel diagnostic biomarkers of COVID-19: a systematic review and meta-analysis
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 19, 2024
Язык: Английский
Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 7, 2024
The
pandemic
of
coronavirus
disease-19
(COVID-19),
provoked
by
the
appearance
a
novel
named
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
required
worldwide
healthcare
emergency.
This
has
elicited
an
immediate
need
for
accelerated
research
into
its
mechanisms
disease,
criteria
diagnosis,
methods
forecasting
outcomes,
and
treatment
approaches.
microRNAs
(miRNAs),
are
diminutive
RNA
molecules,
that
non-coding
participate
in
gene
expression
regulation
post-transcriptionally,
having
important
participation
regulating
immune
processes.
miRNAs
have
granted
substantial
interest
their
impact
on
viral
replication,
cell
proliferation,
modulation
how
host’s
system
responds.
narrative
review
delves
host
miRNAs’
multifaceted
roles
within
COVID-19
context,
highlighting
involvement
disease
progression,
diagnostics,
prognostics
aspects,
given
stability
biological
fluids
varied
profiles
when
responding
to
infection.
Additionally,
we
discuss
complicated
interactions
between
SARS-CoV-2
cellular
machinery
facilitated
revealing
dysregulation
miRNA
advances
evasion,
inflammatory
responses.
Furthermore,
it
investigates
potential
as
therapeutic
agents,
whether
synthetic
or
naturally
occurring,
which
could
be
harnessed
either
mitigate
harmful
inflammation
enhance
antiviral
However,
searching
more
deeply
is
needed
clarify
involved
pathogenesis
COVID-19,
diagnosis
processes,
prognostic
assessments,
approaches
patients.
Язык: Английский
Polypurine Reverse Hoogsteen hairpins as a therapeutic tool for SARS-CoV-2 infection
Journal of Biological Chemistry,
Год журнала:
2024,
Номер
300(11), С. 107884 - 107884
Опубликована: Окт. 11, 2024
Язык: Английский
Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections During the COVID-19 Era
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11624 - 11624
Опубликована: Окт. 29, 2024
Extensive
research
has
been
conducted
on
the
SARS-CoV-2
virus
in
association
with
various
infectious
diseases
to
understand
pathophysiology
of
infection
and
potential
co-infections.
In
tropical
countries,
exposure
local
viruses
may
alter
course
coinfection.
Notably,
only
a
portion
antibodies
produced
against
proteins
demonstrate
neutralizing
properties,
immune
response
following
natural
tends
be
temporary.
contrast,
long-lasting
IgG
are
common
after
dengue
infections.
cases
where
preexisting
from
an
initial
bind
different
serotype
during
subsequent
infection,
there
is
for
antibody-dependent
enhancement
(ADE)
formation
complexes
associated
disease
severity.
Both
infections
can
result
immunodeficiency.
Viral
both
interfere
host's
IFN-I
signaling.
Additionally,
cytokine
storm
occur
viral
impairing
proper
response,
autoantibodies
wide
array
appear
convalescence.
Most
reported
typically
short-lived.
Vaccines
affecting
enhancing
clearance.
A
comprehensive
analysis
pathogenicity
revisited
prevent
severity,
mortality.
Язык: Английский