Food & Function, Год журнала: 2020, Номер 11(9), С. 7596 - 7610
Опубликована: Янв. 1, 2020
The effect of meal viscosity imparted by the konjac glucomannan on gastric emptying was explored with a human simulator, which followed consumer test to reveal relationship between and satiating capacity.
Язык: Английский
Neurogastroenterology & Motility, Год журнала: 2019, Номер 31(4)
Опубликована: Фев. 10, 2019
Abstract There have been many recent advances in the understanding of various aspects physiology gastric motility and emptying. Earlier studies had discovered remarkable ability stomach to regulate timing rate emptying ingested food constituents underlying motor activity. Recent shown that two parallel neural circuits, inhibitory vagal circuit (GIVMC) excitatory (GEVMC), mediate inhibition excitation therefore The GIVMC includes preganglionic cholinergic neurons DMV postganglionic myenteric plexus act by releasing nitric oxide, ATP, peptide VIP. GEVMC distinct plexus. Smooth muscle is final target these circuits. role intramuscular interstitial cells Cajal neuromuscular transmission remains debatable. circuits are differentially regulated different sets NTS afferents. In digestive period, hormones including cholecystokinin GLP‐1 inhibit via GIVMC, inter‐digestive ghrelin motilin hasten stimulating GEVMC. also connected anorexigenic orexigenic pathways, respectively. Identification control may provide better delineation pathophysiology abnormal its relationship satiety signals intake.
Язык: Английский
Процитировано
274
Nutrients, Год журнала: 2018, Номер 10(3), С. 275 - 275
Опубликована: Фев. 28, 2018
Gastrointestinal transit time may be an important determinant of glucose homeostasis and metabolic health through effects on nutrient absorption microbial composition, among other mechanisms. Modulation gastrointestinal one the mechanisms underlying beneficial dietary fibers. These include improved a reduced risk developing diseases such as obesity type 2 diabetes mellitus. In this review, we first discuss regulation gastric emptying rate, small intestinal colonic well their relation to health. Subsequently, briefly address reported different fibers what extent fiber-induced benefits mediated modulation transit.
Язык: Английский
Процитировано
265
Diabetes Care, Год журнала: 2016, Номер 39(6), С. 902 - 911
Опубликована: Май 13, 2016
Since the 2007 Diabetes Surgery Summit in Rome, Italy, and subsequent publishing of world’s first guidelines for surgical treatment type 2 diabetes (T2D), much new evidence regarding efficacy safety metabolic surgery has emerged. Additional observational cohort studies support superior effects over medical with respect to glycemic control, weight loss, even reduction mortality microvascular complications associated T2D. Furthermore, data suggest that perioperative morbidity (5% 0.3%, respectively) are now similar common low-risk procedures, such as cholecystectomy hysterectomy. The largest advance, however, been completion 11 randomized controlled trials from around globe compare These follow-up duration 1–5 years involve nearly 800 patients without major complication rates less than 5% a reoperation rate 8%. All but 1 have shown superiority management at achieving remission or improvement. was also improving cardiovascular risk factors, loss dyslipidemia, while reducing medication burden. This should help guide physicians across appropriate use an effective suffering T2D obesity.
Язык: Английский
Процитировано
196
Metabolism, Год журнала: 2019, Номер 96, С. 46 - 55
Опубликована: Апрель 25, 2019
Язык: Английский
Процитировано
184
Surgery for Obesity and Related Diseases, Год журнала: 2018, Номер 14(5), С. 708 - 714
Опубликована: Март 8, 2018
Язык: Английский
Процитировано
178
Diabetes, Год журнала: 2016, Номер 65(11), С. 3473 - 3481
Опубликована: Авг. 8, 2016
Hyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in presence insulin resistance. We assessed whether glucagon also involved adaptation to A total 1,437 individuals underwent oral glucose tolerance test with measurements circulating glucose, insulin, and concentrations at 0, 30 120 min. Early suppression was defined as period from 0 min, late min after intake. Insulin sensitivity estimated by validated index. Individuals screen-detected diabetes had 30% higher fasting levels diminished early suppression, but greater when compared normal (P ≤ 0.014). Higher resistance associated levels, less < 0.001). The relationship between nonlinear In conclusion, increased delayed together develop parallel Therefore, during may depend not only on hyperinsulinemia ability suppress
Язык: Английский
Процитировано
172
Diabetes Therapy, Год журнала: 2018, Номер 9(S1), С. 1 - 42
Опубликована: Июнь 22, 2018
This article is a comprehensive review of diabetic gastroparesis, defined as delayed or disordered gastric emptying, including basic principles and current trends in management. includes sections on anatomy physiology, diagnosis differential well management guidelines for treatment gastroparesis. Diabetic gastroparesis (DGp) component autonomic neuropathy resulting from long-standing poorly controlled type 1 2 diabetes. The diagnostic workup DGp first excludes obstruction other causes medications that may mimic delayed/disordered emptying. Targeting nutrition, hydration, symptomatic relief glycemic control are mainstays DGp. Additionally, optimal good management, often involving customizing insulin delivery using basal-bolus technology, sensor-augmented pumps continuous glucose monitoring systems. Prokinetic be helpful symptoms, although only limited number currently available the USA. Selected medication-refractory patients with benefit neuromodulation, some surgical interventions pyloric therapies can also done endoscopically. As true any complications, prevention by early more cost-effective.Funding: Hansa Medcell, India.
Язык: Английский
Процитировано
167
Advances in experimental medicine and biology, Год журнала: 2020, Номер unknown, С. 171 - 192
Опубликована: Янв. 1, 2020
Язык: Английский
Процитировано
148
Nutrients, Год журнала: 2021, Номер 13(1), С. 159 - 159
Опубликована: Янв. 6, 2021
Glucose levels in blood must be constantly maintained within a tight physiological range to sustain anabolism. Insulin regulates glucose homeostasis via its effects on production from the liver and kidneys disposal peripheral tissues (mainly skeletal muscle). Blood of are regulated simultaneously by insulin-mediated rates (and kidneys) removal muscle; adipose tissue is key partner this scenario, providing nonesterified fatty acids (NEFA) as an alternative fuel for muscle when depleted. During sleep at night, gradual development insulin resistance, due growth hormone cortisol surges, ensures that will normal by: (a) switching NEFA oxidation (b) modulating liver/kidneys. After meals, several mechanisms (sequence/composition gastric emptying/intestinal absorption, gastrointestinal hormones, hyperglycemia mass action effects, insulin/glucagon secretion/action, de novo lipogenesis disposal) operate concert optimal regulation postprandial fluctuations. The contribution critical. preferentially used dispose over 50% ingested restrict acute increases bloodstream after thus protecting circulation adverse marked hyperinsulinemia.
Язык: Английский
Процитировано
135
Nature Metabolism, Год журнала: 2024, Номер 6(1), С. 61 - 77
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
20