Abstract
Abnormally
short
and
long
sleep
are
associated
with
premature
mortality,
achieving
optimal
duration
has
been
the
focus
of
health
guidelines.
Emerging
research
demonstrates
that
regularity,
day-to-day
consistency
sleep–wake
timing,
can
be
a
stronger
predictor
for
some
outcomes
than
duration.
The
role
regularity
in
however,
not
investigated
large
cohort
objective
data.
We
therefore
aimed
to
compare
how
predicted
risk
all-cause
cause-specific
mortality.
calculated
Sleep
Regularity
Index
(SRI)
scores
from
>
10
million
hours
accelerometer
data
60
977
UK
Biobank
participants
(62.8
±
7.8
years,
55.0%
female,
median[IQR]
SRI:
81.0[73.8–86.3]).
Mortality
was
reported
up
years
after
recording
1859
(4.84
deaths
per
1000
person-years,
mean
(±SD)
follow-up
6.30
0.83
years).
Higher
20%–48%
lower
mortality
(p
<
.001
p
=
0.004),
16%–39%
cancer
0.001
0.017),
22%–57%
cardiometabolic
0.048),
across
top
four
SRI
quintiles
compared
least
regular
quintile.
Results
were
adjusted
age,
sex,
ethnicity,
sociodemographic,
lifestyle,
factors.
duration,
by
comparing
equivalent
models,
nested
SRI-mortality
models
without
0.14–0.20).
These
findings
indicate
is
an
important
may
simple,
effective
target
improving
general
survival.
Diabetes Care,
Год журнала:
2024,
Номер
47(3), С. 331 - 343
Опубликована: Фев. 23, 2024
For
the
first
time,
latest
American
Diabetes
Association/European
Association
for
Study
of
(ADA/EASD)
consensus
guidelines
have
incorporated
a
growing
body
evidence
linking
health
outcomes
associated
with
type
2
diabetes
to
movement
behavior
composition
over
whole
24-h
day.
Of
particular
note,
importance
sleep
as
key
lifestyle
component
in
management
is
promulgated
and
presented
using
three
constructs:
quantity,
quality,
timing
(i.e.,
chronotype).
In
this
narrative
review
we
highlight
some
justifying
inclusion
by
examining
associations
measures
glycemia,
cardiovascular
disease
risk,
mortality.
We
also
consider
potential
mechanisms
implicated
association
between
provide
practical
advice
care
professionals
about
initiating
conversations
pertaining
clinical
care.
particular,
emphasize
measuring
free-living
environment
summary
different
methodologies
targets.
summary,
although
ADA/EASD
report
highlights
central
diabetes,
placing
it,
on
level
playing
field
other
behaviors
(e.g.,
physical
activity
diet),
base
improving
(beyond
disorders)
those
living
limited.
This
should
act
timely
reminder
incorporate
into
consultations,
ongoing
education,
future
interventions.
International Journal of Cardiology Cardiovascular Risk and Prevention,
Год журнала:
2025,
Номер
25, С. 200387 - 200387
Опубликована: Март 7, 2025
Hypertension
is
a
primary
risk
factor
for
cardiovascular
and
cerebrovascular
diseases.
A
number
of
studies
have
suggested
that
sleep
duration
play
an
important
role
in
the
development
hypertension.
young
middle-aged
individuals
characterized
by
low
awareness
treatment
rates,
increasing
adverse
events.
To
further
elucidate
relationship
between
hypertension
individuals,
we
conducted
meta-analysis.
This
study
searched
PubMed,
Embase,
Cochrane
Library
from
January
2003
to
November
5,
2023.
Data
analysis
was
performed
using
STATA
17.
Using
Q
test
I2-statistic,
heterogeneity
included
conducted.
Potential
small-sample
effects
were
evaluated
based
on
symmetry
funnel
plots,
publication
bias
Egger's
test.
16
studies,
which
revealed
both
long
(OR,
1.10;
95
%
CI,
1.05-1.15)
short
(RR:
1.10,
CI:
1.05
1.15)
associated
with
particularly
Asian
populations.
meta-analysis
association
(short
[<7
h]
[≥9
h])
adults,
Sleep
behavior
can
be
modified.
Clinicians
health
professionals
should
encouraged
intensify
efforts
promote
healthy
all
reduce
occurrence
high
blood
pressure
individuals.
Previous
research
on
sleep
and
aging
largely
has
failed
to
illustrate
the
optimal
dose-response
curve
of
this
relationship.
We
aimed
analyze
associations
between
duration
measures
predicted
age.
In
total,
241,713
participants
from
UK
Biobank
were
included.
Habitual
was
collected
baseline
questionnaire.
Four
indicators,
homeostatic
dysregulation
(HD),
phenoAge
(PA),
Klemera-Doubal
method
(KDM),
allostatic
load
(AL),
chosen
assess
Multivariate
linear
regression
models
utilized.
The
association
age
followed
a
U-shape
(All
p
for
nonlinear
<0.05).
Compared
with
individuals
who
7
h/day,
multivariable-adjusted
beta
≤5
≥9
h/day
0.05
(95%
CI
0.03,
0.07)
0.03
0.02,
0.05)
HD,
0.08
0.01,
0.14)
0.36
0.31,
0.41)
PA,
0.21
0.12,
0.30)
0.30
0.23,
0.37)
KDM.
Significant
independent
joint
effects
cystatin
C
(CysC)
gamma
glutamyltransferase
(GGT)
metrics
future
found.
Similar
results
observed
when
conducting
stratification
analyses.
Short
long
associated
accelerated
mediated
by
CysC
GGT.
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(43)
Опубликована: Окт. 15, 2024
Light
enhances
or
disrupts
circadian
rhythms,
depending
on
the
timing
of
exposure.
Circadian
disruption
contributes
to
poor
health
outcomes
that
increase
mortality
risk.
Whether
personal
light
exposure
predicts
risk
has
not
been
established.
We
therefore
investigated
whether
day
and
night
light,
patterns
disrupt
predicted
UK
Biobank
participants
(N
=
88,905,
62.4
±
7.8
y,
57%
female)
wore
sensors
for
1
wk.
Day
exposures
were
defined
by
factor
analysis
24-h
profiles.
A
computational
model
human
pacemaker
was
applied
amplitude
phase
from
data.
Cause-specific
recorded
in
3,750
across
a
mean
(±SD)
follow-up
period
8.0
1.0
y.
Individuals
with
brighter
had
incrementally
lower
all-cause
(adjusted-HR
ranges:
0.84
0.90
[50
70th
percentiles],
0.74
[70
90th],
0.66
0.83
[90
100th]),
those
higher
(aHR
1.15
1.18
1.21
1.34
compared
individuals
darker
environments
(0
50th
percentiles).
range:
0.96
per
SD),
earlier
1.16
1.30),
later
1.13
1.20)
risks.
cardiometabolic
mortality,
larger
hazard
ratios
than
other
causes.
Findings
robust
adjustment
age,
sex,
ethnicity,
photoperiod,
sociodemographic
lifestyle
factors.
Minimizing
maximizing
keeping
regular
light–dark
enhance
rhythms
may
promote
longevity.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 14, 2023
Previous
research
has
reported
that
the
gut
microbiota
performs
an
essential
role
in
sleep
through
microbiome-gut-brain
axis.
However,
causal
association
between
and
remains
undetermined.We
performed
a
two-sample,
bidirectional
Mendelian
randomization
(MR)
analysis
using
genome-wide
study
summary
data
of
self-reported
traits
from
MiBioGen
consortium
UK
Biobank
to
investigate
relationships
119
bacterial
genera
seven
sleep-associated
traits.
We
calculated
effect
estimates
by
inverse-variance
weighted
(as
main
method),
maximum
likelihood,
simple
model,
median,
MR-Egger
methods,
whereas
heterogeneity
pleiotropy
were
detected
measured
MR
residual
sum
outlier
method,
Cochran's
Q
statistics,
regression.In
forward
analysis,
concluded
genetic
forecasts
relative
abundance
42
had
effects
on
In
reverse
39
genera,
13
which
overlapped
with
analysis.In
conclusion,
our
indicates
may
be
involved
regulation
sleep,
conversely,
changes
also
alter
microbiota.
These
findings
suggest
underlying
reciprocal
sleep.
