Causal Association of Sleep Traits with All-Cause and Cause-Specific Mortality: A Prospective Cohort and Mendelian Randomization Study DOI
Jinjin Zhang, Hao Yu, Lirui Jiao

et al.

Rejuvenation Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

The study aimed to explore the association between different sleep traits and all-cause mortality as well validate causality in through mendelian randomization (MR). We analyzed 451,420 European ancestry participants from UK Biobank. Multivariable-adjusted Cox proportional hazards model was conducted evaluate mortality. In MR analysis, inverse variance weighting (IVW) method applied primary analysis investigate causal During a median follow-up period of 12.68 years, 34,397 individuals died. Observational analyses showed multivariate-adjusted hazard ratio (HR) 95% confidence intervals (CIs) for short sleep, long early chronotype, daytime sleepiness, napping, insomnia with mortality, 1.246 (1.195, 1.298), 1.735 (1.643, 1.831), 0.931 (0.909, 0.953), 1.276 (1.212, 1.344), 1.299 (1.254, 1.346), 1.117 (1.091, 1.142) (All p < 0.0001). Based on Biobank, indicated napping an increased risk (odd [OR]: 1.219, CI: 1.071-1.387, = 0.003), which may be largely attributable cancer disease (OR: 1.188, 1.009-1.399, 0.039). found no duration, insomnia, risk. associations were directionally replicated FinnGen. Our findings suggest potential middle-aged older persons. finding could have important implications evaluating habits decrease

Language: Английский

Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study DOI Creative Commons
Daniel P. Windred, A Burns, Jacqueline M. Lane

et al.

SLEEP, Journal Year: 2023, Volume and Issue: 47(1)

Published: Sept. 21, 2023

Abstract Abnormally short and long sleep are associated with premature mortality, achieving optimal duration has been the focus of health guidelines. Emerging research demonstrates that regularity, day-to-day consistency sleep–wake timing, can be a stronger predictor for some outcomes than duration. The role regularity in however, not investigated large cohort objective data. We therefore aimed to compare how predicted risk all-cause cause-specific mortality. calculated Sleep Regularity Index (SRI) scores from &gt; 10 million hours accelerometer data 60 977 UK Biobank participants (62.8 ± 7.8 years, 55.0% female, median[IQR] SRI: 81.0[73.8–86.3]). Mortality was reported up years after recording 1859 (4.84 deaths per 1000 person-years, mean (±SD) follow-up 6.30 0.83 years). Higher 20%–48% lower mortality (p &lt; .001 p = 0.004), 16%–39% cancer 0.001 0.017), 22%–57% cardiometabolic 0.048), across top four SRI quintiles compared least regular quintile. Results were adjusted age, sex, ethnicity, sociodemographic, lifestyle, factors. duration, by comparing equivalent models, nested SRI-mortality models without 0.14–0.20). These findings indicate is an important may simple, effective target improving general survival.

Language: Английский

Citations

89

Waking Up to the Importance of Sleep in Type 2 Diabetes Management: A Narrative Review DOI Open Access
Joseph Henson, Alix Covenant, Andrew P. Hall

et al.

Diabetes Care, Journal Year: 2024, Volume and Issue: 47(3), P. 331 - 343

Published: Feb. 23, 2024

For the first time, latest American Diabetes Association/European Association for Study of (ADA/EASD) consensus guidelines have incorporated a growing body evidence linking health outcomes associated with type 2 diabetes to movement behavior composition over whole 24-h day. Of particular note, importance sleep as key lifestyle component in management is promulgated and presented using three constructs: quantity, quality, timing (i.e., chronotype). In this narrative review we highlight some justifying inclusion by examining associations measures glycemia, cardiovascular disease risk, mortality. We also consider potential mechanisms implicated association between provide practical advice care professionals about initiating conversations pertaining clinical care. particular, emphasize measuring free-living environment summary different methodologies targets. summary, although ADA/EASD report highlights central diabetes, placing it, on level playing field other behaviors (e.g., physical activity diet), base improving (beyond disorders) those living limited. This should act timely reminder incorporate into consultations, ongoing education, future interventions.

Language: Английский

Citations

22

The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma DOI
Sarah Zaman, Jason H. Wasfy, Vikas Kapil

et al.

The Lancet, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

3

Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals DOI Creative Commons
Daniel P. Windred, A Burns, Jacqueline M. Lane

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(43)

Published: Oct. 15, 2024

Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts risk has not been established. We therefore investigated whether day and night light, patterns disrupt predicted UK Biobank participants (N = 88,905, 62.4 ± 7.8 y, 57% female) wore sensors for 1 wk. Day exposures were defined by factor analysis 24-h profiles. A computational model human pacemaker was applied amplitude phase from data. Cause-specific recorded in 3,750 across a mean (±SD) follow-up period 8.0 1.0 y. Individuals with brighter had incrementally lower all-cause (adjusted-HR ranges: 0.84 0.90 [50 70th percentiles], 0.74 [70 90th], 0.66 0.83 [90 100th]), those higher (aHR 1.15 1.18 1.21 1.34 compared individuals darker environments (0 50th percentiles). range: 0.96 per SD), earlier 1.16 1.30), later 1.13 1.20) risks. cardiometabolic mortality, larger hazard ratios than other causes. Findings robust adjustment age, sex, ethnicity, photoperiod, sociodemographic lifestyle factors. Minimizing maximizing keeping regular light–dark enhance rhythms may promote longevity.

Language: Английский

Citations

11

Daytime napping and risk of incident main adverse cardiovascular events and mortality among adults with type 2 diabetes DOI
Xiu Hong Yang, Can Liu, Xin Jiang

et al.

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: 222, P. 112067 - 112067

Published: Feb. 25, 2025

Language: Английский

Citations

2

Association of sleep duration with hypertension in young and middle-aged adults: A systematic review and meta-analysis DOI Creative Commons
Lei Yang,

Fang-Xiao Hu,

Kun Wang

et al.

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: 25, P. 200387 - 200387

Published: March 7, 2025

Hypertension is a primary risk factor for cardiovascular and cerebrovascular diseases. A number of studies have suggested that sleep duration play an important role in the development hypertension. young middle-aged individuals characterized by low awareness treatment rates, increasing adverse events. To further elucidate relationship between hypertension individuals, we conducted meta-analysis. This study searched PubMed, Embase, Cochrane Library from January 2003 to November 5, 2023. Data analysis was performed using STATA 17. Using Q test I2-statistic, heterogeneity included conducted. Potential small-sample effects were evaluated based on symmetry funnel plots, publication bias Egger's test. 16 studies, which revealed both long (OR, 1.10; 95 % CI, 1.05-1.15) short (RR: 1.10, CI: 1.05 1.15) associated with particularly Asian populations. meta-analysis association (short [<7 h] [≥9 h]) adults, Sleep behavior can be modified. Clinicians health professionals should encouraged intensify efforts promote healthy all reduce occurrence high blood pressure individuals.

Language: Английский

Citations

2

Associations between gut microbiota and sleep: a two-sample, bidirectional Mendelian randomization study DOI Creative Commons
Jun Wu, Baofu Zhang, Shengjie Zhou

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 14, 2023

Previous research has reported that the gut microbiota performs an essential role in sleep through microbiome-gut-brain axis. However, causal association between and remains undetermined.We performed a two-sample, bidirectional Mendelian randomization (MR) analysis using genome-wide study summary data of self-reported traits from MiBioGen consortium UK Biobank to investigate relationships 119 bacterial genera seven sleep-associated traits. We calculated effect estimates by inverse-variance weighted (as main method), maximum likelihood, simple model, median, MR-Egger methods, whereas heterogeneity pleiotropy were detected measured MR residual sum outlier method, Cochran's Q statistics, regression.In forward analysis, concluded genetic forecasts relative abundance 42 had effects on In reverse 39 genera, 13 which overlapped with analysis.In conclusion, our indicates may be involved regulation sleep, conversely, changes also alter microbiota. These findings suggest underlying reciprocal sleep.

Language: Английский

Citations

20

U‐shaped association between sleep duration and biological aging: Evidence from the UK Biobank study DOI Creative Commons
Xuanyang Wang,

Xuemin Yan,

Mengdi Li

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 23(7)

Published: March 31, 2024

Previous research on sleep and aging largely has failed to illustrate the optimal dose-response curve of this relationship. We aimed analyze associations between duration measures predicted age. In total, 241,713 participants from UK Biobank were included. Habitual was collected baseline questionnaire. Four indicators, homeostatic dysregulation (HD), phenoAge (PA), Klemera-Doubal method (KDM), allostatic load (AL), chosen assess Multivariate linear regression models utilized. The association age followed a U-shape (All p for nonlinear <0.05). Compared with individuals who 7 h/day, multivariable-adjusted beta ≤5 ≥9 h/day 0.05 (95% CI 0.03, 0.07) 0.03 0.02, 0.05) HD, 0.08 0.01, 0.14) 0.36 0.31, 0.41) PA, 0.21 0.12, 0.30) 0.30 0.23, 0.37) KDM. Significant independent joint effects cystatin C (CysC) gamma glutamyltransferase (GGT) metrics future found. Similar results observed when conducting stratification analyses. Short long associated accelerated mediated by CysC GGT.

Language: Английский

Citations

9

Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review DOI Creative Commons
Huifang Guan, Jiaxing Tian, Ying Wang

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 4, 2024

Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular and cerebrovascular which have emerged leading contributors morbidity mortality. review comprehensively explores the pathophysiological mechanisms underlying these protective strategies, both existing emerging secondary preventive measures. Furthermore, we delve into applications of experimental models methodologies in foundational research while also highlighting current limitations future directions. Specifically, focus on literature published post-2020 concerning prevention complications patients with T2DM by conducting targeted studies supported robust evidence offer holistic perspective.

Language: Английский

Citations

7

Letter to “Daytime napping and risk of incident main adverse cardiovascular events and mortality among adults with type 2 diabetes” DOI

Siyu Qiao,

Yuelai Chen

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112084 - 112084

Published: March 1, 2025

Language: Английский

Citations

1