International Journal of Epidemiology, Год журнала: 2024, Номер 53(3)
Опубликована: Апрель 11, 2024
Patients with type 2 diabetes (T2D) may disproportionately suffer the adverse cardiovascular effects of air pollution, but relevant evidence on microvascular outcome is lacking. We aimed to examine association between pollution exposure and risk complications among patients T2D.
Язык: Английский
SLEEP, Год журнала: 2023, Номер 47(1)
Опубликована: Сен. 21, 2023
Abstract Abnormally short and long sleep are associated with premature mortality, achieving optimal duration has been the focus of health guidelines. Emerging research demonstrates that regularity, day-to-day consistency sleep–wake timing, can be a stronger predictor for some outcomes than duration. The role regularity in however, not investigated large cohort objective data. We therefore aimed to compare how predicted risk all-cause cause-specific mortality. calculated Sleep Regularity Index (SRI) scores from > 10 million hours accelerometer data 60 977 UK Biobank participants (62.8 ± 7.8 years, 55.0% female, median[IQR] SRI: 81.0[73.8–86.3]). Mortality was reported up years after recording 1859 (4.84 deaths per 1000 person-years, mean (±SD) follow-up 6.30 0.83 years). Higher 20%–48% lower mortality (p < .001 p = 0.004), 16%–39% cancer 0.001 0.017), 22%–57% cardiometabolic 0.048), across top four SRI quintiles compared least regular quintile. Results were adjusted age, sex, ethnicity, sociodemographic, lifestyle, factors. duration, by comparing equivalent models, nested SRI-mortality models without 0.14–0.20). These findings indicate is an important may simple, effective target improving general survival.
Язык: Английский
Процитировано
88
Diabetes Care, Год журнала: 2024, Номер 47(3), С. 331 - 343
Опубликована: Фев. 23, 2024
For the first time, latest American Diabetes Association/European Association for Study of (ADA/EASD) consensus guidelines have incorporated a growing body evidence linking health outcomes associated with type 2 diabetes to movement behavior composition over whole 24-h day. Of particular note, importance sleep as key lifestyle component in management is promulgated and presented using three constructs: quantity, quality, timing (i.e., chronotype). In this narrative review we highlight some justifying inclusion by examining associations measures glycemia, cardiovascular disease risk, mortality. We also consider potential mechanisms implicated association between provide practical advice care professionals about initiating conversations pertaining clinical care. particular, emphasize measuring free-living environment summary different methodologies targets. summary, although ADA/EASD report highlights central diabetes, placing it, on level playing field other behaviors (e.g., physical activity diet), base improving (beyond disorders) those living limited. This should act timely reminder incorporate into consultations, ongoing education, future interventions.
Язык: Английский
Процитировано
21
The Lancet, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
3
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(43)
Опубликована: Окт. 15, 2024
Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts risk has not been established. We therefore investigated whether day and night light, patterns disrupt predicted UK Biobank participants (N = 88,905, 62.4 ± 7.8 y, 57% female) wore sensors for 1 wk. Day exposures were defined by factor analysis 24-h profiles. A computational model human pacemaker was applied amplitude phase from data. Cause-specific recorded in 3,750 across a mean (±SD) follow-up period 8.0 1.0 y. Individuals with brighter had incrementally lower all-cause (adjusted-HR ranges: 0.84 0.90 [50 70th percentiles], 0.74 [70 90th], 0.66 0.83 [90 100th]), those higher (aHR 1.15 1.18 1.21 1.34 compared individuals darker environments (0 50th percentiles). range: 0.96 per SD), earlier 1.16 1.30), later 1.13 1.20) risks. cardiometabolic mortality, larger hazard ratios than other causes. Findings robust adjustment age, sex, ethnicity, photoperiod, sociodemographic lifestyle factors. Minimizing maximizing keeping regular light–dark enhance rhythms may promote longevity.
Язык: Английский
Процитировано
11
Diabetes Research and Clinical Practice, Год журнала: 2025, Номер 222, С. 112067 - 112067
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
2
International Journal of Cardiology Cardiovascular Risk and Prevention, Год журнала: 2025, Номер 25, С. 200387 - 200387
Опубликована: Март 7, 2025
Hypertension is a primary risk factor for cardiovascular and cerebrovascular diseases. A number of studies have suggested that sleep duration play an important role in the development hypertension. young middle-aged individuals characterized by low awareness treatment rates, increasing adverse events. To further elucidate relationship between hypertension individuals, we conducted meta-analysis. This study searched PubMed, Embase, Cochrane Library from January 2003 to November 5, 2023. Data analysis was performed using STATA 17. Using Q test I2-statistic, heterogeneity included conducted. Potential small-sample effects were evaluated based on symmetry funnel plots, publication bias Egger's test. 16 studies, which revealed both long (OR, 1.10; 95 % CI, 1.05-1.15) short (RR: 1.10, CI: 1.05 1.15) associated with particularly Asian populations. meta-analysis association (short [<7 h] [≥9 h]) adults, Sleep behavior can be modified. Clinicians health professionals should encouraged intensify efforts promote healthy all reduce occurrence high blood pressure individuals.
Язык: Английский
Процитировано
2
Diabetes Research and Clinical Practice, Год журнала: 2025, Номер unknown, С. 112084 - 112084
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Авг. 14, 2023
Previous research has reported that the gut microbiota performs an essential role in sleep through microbiome-gut-brain axis. However, causal association between and remains undetermined.We performed a two-sample, bidirectional Mendelian randomization (MR) analysis using genome-wide study summary data of self-reported traits from MiBioGen consortium UK Biobank to investigate relationships 119 bacterial genera seven sleep-associated traits. We calculated effect estimates by inverse-variance weighted (as main method), maximum likelihood, simple model, median, MR-Egger methods, whereas heterogeneity pleiotropy were detected measured MR residual sum outlier method, Cochran's Q statistics, regression.In forward analysis, concluded genetic forecasts relative abundance 42 had effects on In reverse 39 genera, 13 which overlapped with analysis.In conclusion, our indicates may be involved regulation sleep, conversely, changes also alter microbiota. These findings suggest underlying reciprocal sleep.
Язык: Английский
Процитировано
20
Aging Cell, Год журнала: 2024, Номер 23(7)
Опубликована: Март 31, 2024
Previous research on sleep and aging largely has failed to illustrate the optimal dose-response curve of this relationship. We aimed analyze associations between duration measures predicted age. In total, 241,713 participants from UK Biobank were included. Habitual was collected baseline questionnaire. Four indicators, homeostatic dysregulation (HD), phenoAge (PA), Klemera-Doubal method (KDM), allostatic load (AL), chosen assess Multivariate linear regression models utilized. The association age followed a U-shape (All p for nonlinear <0.05). Compared with individuals who 7 h/day, multivariable-adjusted beta ≤5 ≥9 h/day 0.05 (95% CI 0.03, 0.07) 0.03 0.02, 0.05) HD, 0.08 0.01, 0.14) 0.36 0.31, 0.41) PA, 0.21 0.12, 0.30) 0.30 0.23, 0.37) KDM. Significant independent joint effects cystatin C (CysC) gamma glutamyltransferase (GGT) metrics future found. Similar results observed when conducting stratification analyses. Short long associated accelerated mediated by CysC GGT.
Язык: Английский
Процитировано
9
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Март 4, 2024
Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular and cerebrovascular which have emerged leading contributors morbidity mortality. review comprehensively explores the pathophysiological mechanisms underlying these protective strategies, both existing emerging secondary preventive measures. Furthermore, we delve into applications of experimental models methodologies in foundational research while also highlighting current limitations future directions. Specifically, focus on literature published post-2020 concerning prevention complications patients with T2DM by conducting targeted studies supported robust evidence offer holistic perspective.
Язык: Английский
Процитировано
7