Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(2), С. 338 - 366
Опубликована: Янв. 18, 2024
This
review
summarizes
examples
of
organic
electrosynthesis
from
the
peer-reviewed
literature
2000
to
2023
that
have
been
conducted
on
scales
20
g
or
above.
A
significant
portion
these
were
a
≤100
scale,
while
detailed
reports
kilogram-scale
remain
scarce
in
pharmaceutical
industry.
In
addition
chemical
transformation,
this
also
highlights
type
reactor
used
and
projected
productivity
metric
as
ways
compare
different
reports.
The
selected
scale-ups
described
herein
illustrate
remaining
challenges
currently
preventing
routine
use
large-scale
Язык: Английский
Electrosynthesis of iminophosphoranes and applications in nickel catalysis
Chemical Science,
Год журнала:
2024,
Номер
15(16), С. 5980 - 5992
Опубликована: Янв. 1, 2024
N
-Cyano
iminophosphoranes
are
synthesized
using
electrochemistry
and
evaluated
as
ligands
in
various
nickel-catalysed
reactions.
The
electronic
structural
properties
of
these
were
studied
both
computationally
experimentally.
Язык: Английский
Electrosynthesis of Aryliminophosphoranes in Continuous Flow
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
366(4), С. 955 - 960
Опубликована: Июль 28, 2023
Abstract
A
practical
electrochemical
method
for
synthesizing
aryliminophosphoranes
from
widely
available
nitro(hetero)arenes
in
a
continuous‐flow
system
is
presented.
The
utilization
of
flow
technology
offers
several
advantages
to
our
approach,
including
the
elimination
need
supporting
electrolyte
and
enhanced
scalability.
Our
demonstrates
good
tolerance
towards
various
functional
groups,
with
electron‐deficient
nitroarenes
being
particularly
suitable
this
strategy.
In
addition,
we
have
demonstrated
versatility
as
intermediates
anilines,
amines,
amides.
To
further
enhance
utility
developed
telescoped
that
utilizes
tube‐in‐tube
setup
in‐situ
production
isocyanates.
Язык: Английский