Environmental Pollution, Год журнала: 2022, Номер 313, С. 120128 - 120128
Опубликована: Сен. 8, 2022
Язык: Английский
EFSA Journal, Год журнала: 2021, Номер 19(6)
Опубликована: Июнь 1, 2021
The role of food-producing environments in the emergence and spread antimicrobial resistance (AMR) EU plant-based food production, terrestrial animals (poultry, cattle pigs) aquaculture was assessed. Among various sources transmission routes identified, fertilisers faecal origin, irrigation surface water for were considered major importance. For animal potential consist feed, humans, water, air/dust, soil, wildlife, rodents, arthropods equipment. those, evidence found introduction with feed other sources, importance could not be Several ARB highest priority public health, such as carbapenem or extended-spectrum cephalosporin and/or fluoroquinolone-resistant Enterobacterales (including Salmonella enterica), Campylobacter spp., methicillin-resistant Staphylococcus aureus glycopeptide-resistant Enterococcus faecium E. faecalis identified. ARGs blaCTX-M, blaVIM, blaNDM, blaOXA-48-like, blaOXA-23, mcr, armA, vanA, cfr optrA reported. These bacteria genes identified different at primary post-harvest level, particularly faeces/manure, soil water. all sectors, reducing occurrence microbial contamination fertilisers, production environment minimising persistence/recycling within facilities is a priority. Proper implementation good hygiene practices, biosecurity safety management systems very important. Potential AMR-specific interventions are early stages development. Many data gaps relating to relevance routes, diversity ARGs, effectiveness mitigation measures Representative epidemiological attribution studies on AMR its effective control linked One Health environmental initiatives, urgently required.
Язык: Английский
Процитировано
200
Environmental Evidence, Год журнала: 2022, Номер 11(1)
Опубликована: Март 12, 2022
Antimicrobial resistance (AMR) is predicted to become the leading cause of death by 2050 with antibiotic being an important component. Anthropogenic pollution introduces resistant bacteria (ARB) and genes (ARGs) natural environment. Currently, there limited empirical evidence demonstrating whether humans are exposed environmental AMR this exposure can result in measurable human health outcomes. In recent years has been increasing interest role environment disparate on transmission generated but no systematic attempt summarise this. We aim create two maps that will collate for (1) from a global scale (2) state United Kingdom.Search strategies were developed each map. Searches undertaken 13 bibliographic databases. Key websites searched experts consulted grey literature. Search results managed using EndNote X8. Titles abstracts screened, followed full texts. Articles double screened at minimum 10% both stages consistency checking discussion when disagreements arose. Data extraction occurred Excel bespoke forms designed. extracted selected study included: information; site location; source; route; outcome (Map 1); prevalence/percentage/abundance ARB/antibiotic elements 2) design. EviAtlas was used visualise outputs.For Map 1, 40 articles included, 11,016 unique identified searches, which investigated humans. Results 1 showed consumption/ingestion most studied route. Exposure (n = 17), infection 16) colonisation 11) as similar number times, mortality infrequently 2). addition, E. coli highly bacterium 16). For 2, we included 62 studies quantifying ARB or UK, 6874 searches. The researched species mixed communities 32). common methodology employed research question phenotypic testing 37). commonly reported characterisation ARBs 40), ARGs 35). Other genetic elements, such screening intI1 15) (which encodes Class integron proxy ARGs) point mutations 1) less frequently reported. Both focused towards aquatic environments.Both be policy makers show UK landscapes provide overview impacts interacting have also clusters may perform meta-analyses gaps base where future primary should focus.The online version contains supplementary material available 10.1186/s13750-022-00262-2.
Язык: Английский
Процитировано
82
Microorganisms, Год журнала: 2024, Номер 12(4), С. 772 - 772
Опубликована: Апрель 11, 2024
Antibiotic resistance has emerged as a significant global public health issue, driven by the rapid adaptation of microorganisms to commonly prescribed antibiotics. Colistin, previously regarded last-resort antibiotic for treating infections caused Gram-negative bacteria, is increasingly becoming resistant due chromosomal mutations and acquisition genes carried plasmids, particularly mcr genes. The mobile colistin gene (mcr-1) was first discovered in E. coli from China 2016. Since that time, studies have reported different variants ranging mcr-1 mcr-10, mainly Enterobacteriaceae various parts world, which major concern health. co-presence colistin-resistant with other determinants further complicates treatment strategies underscores urgent need enhanced surveillance antimicrobial stewardship efforts. Therefore, understanding mechanisms driving monitoring its prevalence are essential steps addressing growing threat preserving efficacy existing This review critical role last-choice antibiotic, elucidates dissemination genes, explores evaluates current detection methods bacteria. objective shed light on these key aspects combating
Язык: Английский
Процитировано
54
Microorganisms, Год журнала: 2023, Номер 11(9), С. 2127 - 2127
Опубликована: Авг. 22, 2023
The emergence of antimicrobial resistance (AMR) is a global health problem without geographic boundaries. This increases the risk complications and, thus, makes it harder to treat infections, which can result in higher healthcare costs and greater number deaths. Antimicrobials are often used infections from pathogens food-producing animals, making them potential source AMR. Overuse misuse these drugs animal agriculture lead development AMR bacteria, then be transmitted humans through contaminated food or direct contact. It therefore essential take multifaceted, comprehensive, integrated measures, following One Health approach. To address this issue, many countries have implemented regulations limit use. our knowledge, there previous studies based on animals; however, paper adds novelty related livestock, as we include recent publications field worldwide. In work, aim describe most critical high-risk among worldwide problem. We also focus dissemination genes well its consequences animals humans, future strategies tackle threat.
Язык: Английский
Процитировано
41
Journal of Environmental Management, Год журнала: 2022, Номер 309, С. 114643 - 114643
Опубликована: Фев. 9, 2022
Язык: Английский
Процитировано
57
BioMed Research International, Год журнала: 2023, Номер 2023(1)
Опубликована: Янв. 1, 2023
Antimicrobial resistance (AMR) is a significant public health issue in Bangladesh like many other developing countries where data on trends are scarce. Moreover, the existence of multidrug‐resistant (MDR) Escherichia coli exerts an ominous effect poultry sector. Therefore, current systematic review, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, was conducted to find out AMR scenarios E. isolates sourced from environments between 2010 2021. Following PRISMA total 17 published scientific articles were selected this review. This review revealed that 18 64 districts reported poultry, having higher prevalence (combined prevalence: 69.3%, 95% confidence interval, CI: 67.3‐71%). ranged 24.3% 100%. found showed 14 antimicrobial classes 45 different agents, including last‐line (reserve group) antibiotics banned categories treatment infections agricultural animals. Phenotypic against penicillins beta‐lactamase inhibitors (20.2%‐100%), cephalosporins (1.9%‐100%), fluoroquinolones (5.98%‐100%), aminoglycosides (6%‐100%), tetracyclines (17.7%‐100%), carbapenems (13.6%‐72.7%), macrolides (11.8%‐100%), polymyxins (7.9%‐100%), phenicols (20%‐97.2%), sulfa drugs (44.7%‐100%), cephamycins (21.4%‐48.8%), nitrofurans (21.4%‐63.2%), monobactams (1.2%), glycylcyclines (2.3%) recorded last decades Bangladesh. Also, MDR 100% nine 92.7% (95% 91.2‐94%) combined percentage isolates. Twenty‐four genes encoding beta‐lactams ( bla TEM , CTX-M-1 CTX-M-2 CTX-M-9 OXA-1 OXA-47 SHV CITM ), colistin mcr1 mcr3 qnrB qnrS tetA tetB tetC sulfonamides sulI sulII trimethoprim dfrA1 rmtB streptomycin aadA1 gentamicin aac-3-IV erythromycin ereA chloramphenicol catA1 cmlA ) detected The presence their corresponding alarming all communities We suggest regular surveillance program with strong One Health approach lessen hazardous effects industries
Язык: Английский
Процитировано
32
Environmental Pollution, Год журнала: 2023, Номер 320, С. 121035 - 121035
Опубликована: Янв. 6, 2023
Язык: Английский
Процитировано
24
Water Research, Год журнала: 2023, Номер 235, С. 119875 - 119875
Опубликована: Март 14, 2023
Язык: Английский
Процитировано
24
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9727 - 9727
Опубликована: Июнь 4, 2023
Combating antimicrobial resistance (AMR) is among the 10 global health issues identified by World Health Organization (WHO) in 2021. While AMR a naturally occurring process, inappropriate use of antibiotics different settings and legislative gaps has led to its rapid progression. As result, grown into serious menace that impacts not only humans but also animals and, ultimately, entire environment. Thus, effective prophylactic measures, as well more potent non-toxic agents, are pressingly needed. The activity essential oils (EOs) supported consistent research field. Although EOs have been used for centuries, they newcomers when it comes managing infections clinical settings; mainly because methodological largely non-overlapping there insufficient data regarding EOs' vivo toxicity. This review considers concept main determinants, modality which issue globally addressed potential alternative or auxiliary therapy. focus shifted towards pathogenesis, mechanism several against six high priority pathogens listed WHO 2017, new therapeutic solutions required.
Язык: Английский
Процитировано
23
Biosensors, Год журнала: 2024, Номер 14(4), С. 194 - 194
Опубликована: Апрель 16, 2024
Antimicrobial-resistant (AMR) bacteria pose a significant global health threat, and that produce New Delhi metallo-β-lactamase (NDM) are particularly concerning due to their resistance most β-lactam antibiotics, including carbapenems. The emergence spread of NDM-producing genes in food-producing animals highlight the need for fast accurate method detecting AMR bacteria. We therefore propose PCR-coupled CRISPR/Cas12a-based fluorescence assay can detect (blaNDM) Thanks its designed gRNA, this CRISPR/Cas12a system was able simultaneously cleave PCR amplicons ssDNA-FQ reporters, generating signals. Our found be highly specific when tested against other foodborne pathogens do not carry blaNDM also demonstrated an excellent capability distinguish single-nucleotide polymorphism. In case blaNDM-1 carrying E. coli, performed exceptionally well, with detection limit 2.7 × 100 CFU/mL: times better than conventional gel electrophoresis. Moreover, developed detected food samples exhibited enhanced performance compared previously published real-time assays. Thus, novel has considerable potential improve current approaches gene thereby contribute mitigating threat AMR.
Язык: Английский
Процитировано
10