Critical Reviews in Clinical Laboratory Sciences,
Год журнала:
2024,
Номер
61(8), С. 641 - 684
Опубликована: Авг. 9, 2024
The
field
of
pharmacogenetics,
the
investigation
influence
one
or
more
sequence
variants
on
drug
response
phenotypes,
is
a
special
case
pharmacogenomics,
discipline
that
takes
genome-wide
approach.
Massively
parallel,
next
generation
sequencing
(NGS),
has
allowed
pharmacogenetics
to
be
subsumed
by
pharmacogenomics
with
respect
identification
associated
responders
and
non-responders,
optimal
response,
adverse
reactions.
A
plethora
rare
common
naturally-occurring
GPCR
must
considered
in
context
signals
from
across
genome.
Many
fundamentals
were
established
for
G
protein-coupled
receptor
(GPCR)
genes
because
they
are
primary
targets
large
number
therapeutic
drugs.
Functional
studies,
demonstrating
likely-pathogenic
pathogenic
variants,
have
been
integral
establishing
models
used
Molecules,
Год журнала:
2022,
Номер
28(1), С. 106 - 106
Опубликована: Дек. 23, 2022
The
management
of
orofacial
pain
to
alleviate
the
quality
life
affected
patients
is
becoming
increasingly
challenging
for
scientific
research
and
healthcare
professionals.
From
this
perspective,
in
addition
conventional
therapies,
new
alternatives
are
being
sought,
looking
at
use
both
natural
synthetic
products.
Cannabis
sativa
L.
represents
an
interesting
source
bioactive
compounds,
including
non-psychoactive
cannabinoids,
flavonoids,
terpenes,
many
which
effective
improving
intensity.
Here,
we
aim
analyze
possible
mechanisms
action
hemp-derived
compounds
responsible
modulatory
effects
on
pain-related
pathways.
ability
these
act
multiple
through
a
synergistic
effect,
reducing
release
inflammatory
mediators
regulating
response
endocannabinoid
system,
makes
them
agents
alternative
formulations
be
used
pain.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(2), С. 975 - 975
Опубликована: Янв. 17, 2022
The
endocannabinoid
system
(ECS)
is
ubiquitous
in
most
human
tissues,
and
involved
the
regulation
of
mental
health.
Consequently,
its
dysregulation
associated
with
neuropsychiatric
neurodegenerative
disorders.
Together,
ECS
expanded
endocannabinoidome
(eCBome)
are
composed
genes
coding
for
CB1
CB2
cannabinoid
receptors
(CB1R,
CB2R),
endocannabinoids
(eCBs),
metabolic
enzyme
machinery
their
synthesis
catabolism.
activation
CB1R
adverse
effects
on
central
nervous
(CNS),
which
has
limited
therapeutic
use
drugs
that
bind
this
receptor.
discovery
functional
neuronal
CB2R
raised
new
possibilities
potential
safe
targeting
treatment
CNS
Previous
studies
were
not
able
to
detect
mRNA
transcripts
brain
tissue
suggested
CB2Rs
absent
considered
peripheral
receptors.
Studies
done
role
as
a
target
treating
different
disorders
revealed
important
putative
certain
disorders,
requires
further
clinical
validation.
This
review
addresses
recent
advances
including,
but
to,
anxiety,
depression,
schizophrenia,
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
Huntington’s
(HD)
addiction.
Molecules,
Год журнала:
2024,
Номер
29(14), С. 3381 - 3381
Опубликована: Июль 18, 2024
The
emergence
of
inflammatory
diseases
is
a
heavy
burden
on
modern
societies.
Cannabis
has
been
used
for
several
millennia
to
treat
disorders
such
as
rheumatism
or
gout.
Since
the
characterization
cannabinoid
receptors,
CB
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Дек. 22, 2021
Inflammatory
bowel
disease
(IBD)
is
a
general
term
used
to
describe
group
of
chronic
inflammatory
conditions
the
gastrointestinal
tract
unknown
etiology,
including
two
primary
forms:
Crohn's
(CD)
and
ulcerative
colitis
(UC).
The
endocannabinoid
system
(ECS)
plays
an
important
role
in
modulating
many
physiological
processes
intestinal
homeostasis,
modulation
motility,
visceral
sensation,
or
immunomodulation
inflammation
IBD.
It
consists
cannabinoid
receptors
(CB1
CB2),
transporters
for
cellular
uptake
ligands,
endogenous
bioactive
lipids
(Anandamide
2-arachidonoylglycerol),
enzymes
responsible
their
synthesis
degradation
(fatty
acid
amide
hydrolase
monoacylglycerol
lipase),
manipulation
which
through
agonists
antagonists
system,
shows
potential
therapeutic
ECS
disease.
This
review
summarizes
components
on
inflammation,
suggesting
advantages
cannabinoid-based
therapies
Neurobiology of Disease,
Год журнала:
2022,
Номер
170, С. 105773 - 105773
Опубликована: Май 25, 2022
Gut
microbiota
has
implications
in
Central
Nervous
System
(CNS)
disorders.
Our
study
systematically
identified
preclinical
studies
aimed
to
investigate
the
possible
gut
contribution
neuropathy
and
neuropathic
pain.
The
systematic
review
is
reported
accordance
with
PRISMA
checklist
guidelines
outlined
updated
2020.
We
included
research
articles
reporting
neuropathy-related
behavioral
evaluations
and/or
neurological
scores
coupled
analysis
performed
by
high-throughput
technologies
last
ten
years.
Two
investigators
a
search
through
3
electronic
bibliographic
databases
for
full-text
(PubMed,
Scopus,
EMBASE)
three
registries
(Prospero,
SyRF,
bioRxiv),
cross-references,
linear
searches.
assessed
methodological
quality
via
CAMARADES
appraised
heterogeneous
body
of
evidence
narrative
synthesis.
In
total,
there
were
19
eligible
studies.
most
these
reports
showed
significant
changes
setting
conditions.
major
microbiome
remodeling
was
fecal
transplantation.
Mechanistic
proof
gut-CNS
communication
achieved
measuring
inflammatory
mediators,
metabolic
products,
or
neurotransmitters.
As
limitation,
we
found
considerable
heterogeneity
across
conclude
that
current
understanding
findings
suggested
an
association
between
pain
modifications.
provides
basis
further
targeting
managing
symptoms
other
neuroinflammation-based
CNS
protocol
registered
on
international
database
Prospero
under
registration
number
(257628).
Lipids in Health and Disease,
Год журнала:
2022,
Номер
21(1)
Опубликована: Янв. 13, 2022
Abstract
The
discovery
of
the
endocannabinoidome
(eCBome)
is
evolving
gradually
with
yet
to
be
elucidated
functional
lipid
mediators
and
receptors.
diet
modulates
these
bioactive
lipids
gut
microbiome,
both
working
in
an
entwined
alliance.
Mounting
evidence
suggests
that,
different
ways
a
certain
specialisation,
signalling
such
as
N
-acylethanolamines
(NAEs),
2-monoacylglycerols
(2-MAGs),
-acyl-amino
acids
(NAAs),
along
endocannabinoids
(eCBs),
can
modulate
physiological
mechanisms
underpinning
appetite,
food
intake,
macronutrient
metabolism,
pain
sensation,
blood
pressure,
mood,
cognition,
immunity.
This
knowledge
has
been
primarily
utilised
pharmacology
medicine
develop
many
drugs
targeting
fine
specific
molecular
pathways
orchestrating
eCB
eCBome
activity.
Conversely,
contribution
dietary
NAEs,
2-MAGs
eCBs
biological
functions
molecules
little
studied.
In
this
review,
we
discuss
importance
(Wh)
olistic
(E)ndocannabinoidome-Microbiome-Axis
Modulation
through
(N)
utrition
(WHEN),
management
obesity
related
disorders.
Frontiers in Behavioral Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Март 16, 2023
Endocannabinoids
(eCBs)
and
the
expanded
endocannabinoid
system
(ECS)-“endocannabinoidome”,
consists
of
endogenous
ligands,
eCBs,
their
canonical
non-canonical
receptor
subtypes,
synthesizing
metabolizing
enzymes.
This
modulates
a
wide
range
body
functions
acts
as
retrograde
signaling
within
central
nervous
(CNS)
by
inhibition
classical
transmitters,
plays
vital
modulatory
function
on
dopamine,
major
neurotransmitter
in
CNS.
Dopamine
is
involved
different
behavioral
processes
contributes
to
brain
disorders—including
Parkinson’s
disease,
schizophrenia,
drug
addiction.
After
synthesis
neuronal
cytosol,
dopamine
packaged
into
synaptic
vesicles
until
released
extracellular
signals.
Calcium
dependent
activation
results
vesicular
release
interacts
with
systems.
The
ECS,
among
others,
regulation
interaction
occurs
either
through
direct
or
indirect
mechanisms.
cross-talk
between
ECS
dopaminergic
has
important
influence
various
dopamine-related
neurobiological
pathologic
conditions
investigating
this
might
help
identify
therapeutic
targets
options
disorders
CNS
associated
dysregulation.
