Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2021, Volume and Issue: 1867(1), P. 159056 - 159056
Published: Oct. 1, 2021
Language: Английский
Molecules, Journal Year: 2022, Volume and Issue: 28(1), P. 106 - 106
Published: Dec. 23, 2022
The management of orofacial pain to alleviate the quality life affected patients is becoming increasingly challenging for scientific research and healthcare professionals. From this perspective, in addition conventional therapies, new alternatives are being sought, looking at use both natural synthetic products. Cannabis sativa L. represents an interesting source bioactive compounds, including non-psychoactive cannabinoids, flavonoids, terpenes, many which effective improving intensity. Here, we aim analyze possible mechanisms action hemp-derived compounds responsible modulatory effects on pain-related pathways. ability these act multiple through a synergistic effect, reducing release inflammatory mediators regulating response endocannabinoid system, makes them agents alternative formulations be used pain.
Language: Английский
Citations
50
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 975 - 975
Published: Jan. 17, 2022
The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved the regulation of mental health. Consequently, its dysregulation associated with neuropsychiatric neurodegenerative disorders. Together, ECS expanded endocannabinoidome (eCBome) are composed genes coding for CB1 CB2 cannabinoid receptors (CB1R, CB2R), endocannabinoids (eCBs), metabolic enzyme machinery their synthesis catabolism. activation CB1R adverse effects on central nervous (CNS), which has limited therapeutic use drugs that bind this receptor. discovery functional neuronal CB2R raised new possibilities potential safe targeting treatment CNS Previous studies were not able to detect mRNA transcripts brain tissue suggested CB2Rs absent considered peripheral receptors. Studies done role as a target treating different disorders revealed important putative certain disorders, requires further clinical validation. This review addresses recent advances including, but to, anxiety, depression, schizophrenia, Parkinson’s disease (PD), Alzheimer’s (AD), Huntington’s (HD) addiction.
Language: Английский
Citations
47
Molecules, Journal Year: 2024, Volume and Issue: 29(14), P. 3381 - 3381
Published: July 18, 2024
The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat disorders such as rheumatism or gout. Since the characterization cannabinoid receptors, CB
Language: Английский
Citations
11
Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 96 - 108
Published: Jan. 5, 2025
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12
Published: Dec. 22, 2021
Inflammatory bowel disease (IBD) is a general term used to describe group of chronic inflammatory conditions the gastrointestinal tract unknown etiology, including two primary forms: Crohn's (CD) and ulcerative colitis (UC). The endocannabinoid system (ECS) plays an important role in modulating many physiological processes intestinal homeostasis, modulation motility, visceral sensation, or immunomodulation inflammation IBD. It consists cannabinoid receptors (CB1 CB2), transporters for cellular uptake ligands, endogenous bioactive lipids (Anandamide 2-arachidonoylglycerol), enzymes responsible their synthesis degradation (fatty acid amide hydrolase monoacylglycerol lipase), manipulation which through agonists antagonists system, shows potential therapeutic ECS disease. This review summarizes components on inflammation, suggesting advantages cannabinoid-based therapies
Language: Английский
Citations
53
Neurobiology of Disease, Journal Year: 2022, Volume and Issue: 170, P. 105773 - 105773
Published: May 25, 2022
Gut microbiota has implications in Central Nervous System (CNS) disorders. Our study systematically identified preclinical studies aimed to investigate the possible gut contribution neuropathy and neuropathic pain. The systematic review is reported accordance with PRISMA checklist guidelines outlined updated 2020. We included research articles reporting neuropathy-related behavioral evaluations and/or neurological scores coupled analysis performed by high-throughput technologies last ten years. Two investigators a search through 3 electronic bibliographic databases for full-text (PubMed, Scopus, EMBASE) three registries (Prospero, SyRF, bioRxiv), cross-references, linear searches. assessed methodological quality via CAMARADES appraised heterogeneous body of evidence narrative synthesis. In total, there were 19 eligible studies. most these reports showed significant changes setting conditions. major microbiome remodeling was fecal transplantation. Mechanistic proof gut-CNS communication achieved measuring inflammatory mediators, metabolic products, or neurotransmitters. As limitation, we found considerable heterogeneity across conclude that current understanding findings suggested an association between pain modifications. provides basis further targeting managing symptoms other neuroinflammation-based CNS protocol registered on international database Prospero under registration number (257628).
Language: Английский
Citations
34
Psychopharmacology, Journal Year: 2022, Volume and Issue: 239(9), P. 2713 - 2734
Published: July 29, 2022
Language: Английский
Citations
32
Pharmacological Research, Journal Year: 2021, Volume and Issue: 170, P. 105729 - 105729
Published: June 11, 2021
Language: Английский
Citations
33
Lipids in Health and Disease, Journal Year: 2022, Volume and Issue: 21(1)
Published: Jan. 13, 2022
Abstract The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet to be elucidated functional lipid mediators and receptors. diet modulates these bioactive lipids gut microbiome, both working in an entwined alliance. Mounting evidence suggests that, different ways a certain specialisation, signalling such as N -acylethanolamines (NAEs), 2-monoacylglycerols (2-MAGs), -acyl-amino acids (NAAs), along endocannabinoids (eCBs), can modulate physiological mechanisms underpinning appetite, food intake, macronutrient metabolism, pain sensation, blood pressure, mood, cognition, immunity. This knowledge has been primarily utilised pharmacology medicine develop many drugs targeting fine specific molecular pathways orchestrating eCB eCBome activity. Conversely, contribution dietary NAEs, 2-MAGs eCBs biological functions molecules little studied. In this review, we discuss importance (Wh) olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N) utrition (WHEN), management obesity related disorders.
Language: Английский
Citations
24
Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: March 16, 2023
Endocannabinoids (eCBs) and the expanded endocannabinoid system (ECS)-“endocannabinoidome”, consists of endogenous ligands, eCBs, their canonical non-canonical receptor subtypes, synthesizing metabolizing enzymes. This modulates a wide range body functions acts as retrograde signaling within central nervous (CNS) by inhibition classical transmitters, plays vital modulatory function on dopamine, major neurotransmitter in CNS. Dopamine is involved different behavioral processes contributes to brain disorders—including Parkinson’s disease, schizophrenia, drug addiction. After synthesis neuronal cytosol, dopamine packaged into synaptic vesicles until released extracellular signals. Calcium dependent activation results vesicular release interacts with systems. The ECS, among others, regulation interaction occurs either through direct or indirect mechanisms. cross-talk between ECS dopaminergic has important influence various dopamine-related neurobiological pathologic conditions investigating this might help identify therapeutic targets options disorders CNS associated dysregulation.
Language: Английский
Citations
15