Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2023, Номер 130, С. 110924 - 110924
Опубликована: Дек. 20, 2023
Язык: Английский
International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(8), С. 5430 - 5430
Опубликована: Апрель 7, 2023
Parents of children with developmental, behavioural and mental health disorders are increasingly asking whether medicinal cannabis might be a therapeutic option for their child. This paper presents the current evidence in this population. Preliminary from open-label studies suggests potential to ameliorate some symptoms autism spectrum disorder. However, only one double-blind placebo-controlled trial has been completed, inconclusive findings. Synthetic, transdermal cannabidiol gel demonstrated efficacy reducing social avoidance sub-group Fragile X syndrome. Studies planned or underway and/or adolescents autism, intellectual disability, Tourette’s syndrome, anxiety, psychosis, anorexia nervosa number specific neurodevelopmental syndromes. High quality trials is needed guide clinical practice.
Язык: Английский
Процитировано
19
Neurogastroenterology & Motility, Год журнала: 2024, Номер unknown
Опубликована: Сен. 2, 2024
Abstract Background Classical antiemetics that target the serotonin system may not be effective in treating certain nausea and vomiting conditions like cyclic syndrome (CVS) cannabinoid hyperemesis (CHS). As a result, there is need for better therapies to manage symptoms of these disorders, including nausea, vomiting, anxiety. Cannabis often used its purported antiemetic anxiolytic effects, given regulation processes by endocannabinoid (ECS). However, considerable evidence cannabinoids can also produce increase anxiety instances, especially at higher doses. This paradoxical effect on due dysregulation ECS, altering how it maintains contributing pathophysiology CVS or CHS. Purpose The purpose this review highlight involvement ECS stress, vomiting. We discuss prolonged cannabis use, such as case CHS heightened dysregulate affect modulation functions. examines roles stress systems' dysfunction understand underlying mechanisms conditions.
Язык: Английский
Процитировано
7
Computational Biology and Chemistry, Год журнала: 2023, Номер 107, С. 107957 - 107957
Опубликована: Сен. 13, 2023
Язык: Английский
Процитировано
12
NeuroMolecular Medicine, Год журнала: 2024, Номер 26(1)
Опубликована: Май 14, 2024
Abstract The salient features of autism spectrum disorder (ASD) encompass persistent difficulties in social communication, as well the presence restricted and repetitive facets behavior, hobbies, or pursuits, which are often accompanied with cognitive limitations. Over past few decades, a sizable number studies have been conducted to enhance our understanding pathophysiology ASD. Preclinical rat models proven be extremely valuable simulating analyzing roles wide range established environmental genetic factors. Recent research has also demonstrated significant involvement endocannabinoid system (ECS) pathogenesis several neuropsychiatric diseases, including In fact, ECS potential regulate multitude metabolic cellular pathways associated autism, immune system. Moreover, emerged promising target for intervention high predictive validity. Particularly noteworthy resent preclinical rodents, describe onset ASD-like symptoms after various pharmacological interventions targeting ECS, providing encouraging evidence further exploration this area.
Язык: Английский
Процитировано
3
Drug and Alcohol Dependence, Год журнала: 2025, Номер unknown, С. 112579 - 112579
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Pharmacology Biochemistry and Behavior, Год журнала: 2025, Номер 248, С. 173969 - 173969
Опубликована: Фев. 6, 2025
Язык: Английский
Процитировано
0
Frontiers in Psychiatry, Год журнала: 2025, Номер 16
Опубликована: Март 20, 2025
Substance use and the emergence of Novel Psychoactive Substances (NPS) present a significant public health challenge diagnostic dilemma, particularly in context psychosis. The increasing availability psychoactive substances among youth has led to rise Use Disorders (SUDs), with profound implications for mental health. This paper explores psychopathological distinctions between substance-induced psychoses (SIPs) endogenous psychoses, such as schizophrenia, from phenomenological perspective. We emphasize three key aspects: dissociation, automatism, temporality, elucidate underlying mechanisms these conditions. Dissociation, organizer, is central exogenous those triggered by NPS. phenomenon leads fragmentation consciousness, detachment reality, disintegration identity, distinct spaltung observed psychoses. concept theorized De Clerambault, also explored, highlighting its role early stages where cognitive disruptions precede delusions hallucinations. Furthermore, temporal experience SIPs characterized disconnection past future, trapping individuals an “eternal present.” contrasts fragmented temporality patients struggle maintain coherent narrative their lives. approach provides critical insights into clinical differentiation Primary Psychotic (PPDs), emphasizing need targeted interventions that address specific In conclusion, this underscores importance integrating psychopathology practice, face evolving landscape substance Understanding can inform more accurate diagnoses effective treatments, ultimately improving patient outcomes growing issue.
Язык: Английский
Процитировано
0
Translational Stroke Research, Год журнала: 2025, Номер unknown
Опубликована: Май 8, 2025
Язык: Английский
Процитировано
0
Healthcare, Год журнала: 2024, Номер 12(12), С. 1172 - 1172
Опубликована: Июнь 10, 2024
The widespread use of novel psychoactive substances (NPSs)-defined as new narcotic or psychotropic agents not classified under the Single Convention on Narcotic Drugs 1961 Psychotropic Substances 1971-poses a significant challenge to contemporary mental health paradigms due their impact psychiatric disorders. This study revisits and expands upon theory automatism proposed by Gaëtan Gatian de Clérambault, aiming elucidate psychopathological mechanisms underlying substance-induced psychoses (SIP) distinction from non-induced (schizophrenia related disorders). Through phenomenological clinical investigation, we explore relevance in development toxic psychoses, drawing historical literature. research highlights distinctions between induced transition acute chronic psychosis states. De Clérambault's theory, supplemented Janet, Jackson, Bonhoeffer's contributions, provides foundational framework for understanding genesis SIP. Our findings suggest that NPS consumption, particularly among adolescents patients, significantly correlates with increased risks SIP, marked chronicity influenced biological lesions triggered substance use. Furthermore, propose comprehensive integrating automatism, distinctions, mechanisms. aims refine diagnostic criteria therapeutic approaches, addressing gaps practice research. underscores need nuanced advocating paradigm shift assessment treatment approaches better address complexities
Язык: Английский
Процитировано
2
Veterinary Research Communications, Год журнала: 2024, Номер 48(5), С. 2915 - 2941
Опубликована: Авг. 20, 2024
Since the discovery of endocannabinoid system and due to empirical evidence therapeutic effects on several illnesses both in humans animals that follow administration exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed identify expression distribution cannabinoid receptors healthy pathologic organs tissues different animal species define interactions phytocannabinoids with these receptors. In last decade, pharmacokinetics, efficacy tolerability many Cannabis derivatives formulations, mainly containing cannabidiol, main veterinary interest, also investigated. This manuscript summarizes findings reported by scientific published so far molecular mode action phytocannabinoids, localization tissues, as well dogs, cats, horses other interest. A deep knowledge issues is crucial for use purposes species.
Язык: Английский
Процитировано
2