The effect of squalene on lipid profile and some oxidative biomarkers in patients with type 2 diabetes mellitus

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2022, Номер 2(7), С. 144 - 144

Опубликована: Июль 21, 2022

Background: Squalene, as an isoprene, is one of the components amaranth oil and makes up about 8% this oil. Squalene has anti-inflammatory antioxidant effects that have been considered in many studies. In people with uncontrolled diabetes, there increase total cholesterol low-density lipoprotein (LDL) alongside a decrease high-density lipoproteins (HDL).According to studies, squalene can be useful lowering triacylglycerol.Objective: The aim study was investigate whether effect on lipid profile number oxidative biomarkers patients type 2 diabetes.Methods: present study, 30 healthy volunteers were selected control group 120 diabetes mellitus (T2DM) selected. Subjects randomly divided into 4 groups. Group 1 untreated groups 3, 4, 5 treated different doses for 84 days. Lipid profiles oxidant examined days 1, 14, 28, 56, according relevant protocols all groups.Results: Significant differences (P < 0.05) observed between diabetic cholesterol, triglycerides, LDL, HDL, very (VLDL), oxidized (Ox-LDL), malondialdehyde. There significant difference studied levels parameters expressed some days.At days, squalene.Conclusion: This shows bioactive compound effective manage certain symptoms diabetics including VLDL. From our findings, we consumption over duration resulted increased HDL patients. It also decreased VLDL Keywords: profile, biomarkers,

Язык: Английский

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Quantum and tempus theories of function food science in practice

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2023, Номер 3(5), С. 55 - 55

Опубликована: Май 31, 2023

Functional food science has witnessed remarkable advancements in recent years, driven by our evolving understanding of quantum mechanics and the concept time. The interplay between these two theories, namely Quantum theory Tempus theory, opened new avenues for research innovation functional food. integrates theories to better understand complex relationship food, chronic disease, health. explores molecular-level energy, matter, bioactive compounds foods, optimizing their development utilization disease emphasizes timed consumption, aligning foods with circadian rhythms metabolic processes enhanced nutrient absorption, utilization, responses. By synchronizing intake body's natural rhythms, enhances efficacy promoting health preventing disease. Integrating tempus provides a comprehensive approach utilizing potential personalized nutritional interventions improving overall well-being.Keywords: science, compounds, cellular interactions, timing, promotion, nutrition.

Язык: Английский

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The phytochemical study of Eleutherococcus senticosus (Rupr. & Maxim) leaves in hydroponics and soil culture

Functional Foods in Health and Disease, Год журнала: 2023, Номер 13(11), С. 574 - 574

Опубликована: Ноя. 2, 2023

Background: In the medical fieldEleutherococcus senticosus (Rupr. & Maxim) (E. senticosus) or Siberian ginseng is known as a natural adaptogen and immunomodulator. All parts of E. senticosus: roots, stems, leaves, berries, have medicinal properties. medicine, used to treat depression, Alzheimer's Parkinson’s diseases, cardiovascular cerebral ischemia, diabetes. The adaptogenic properties plant are related its rich composition biologically active compounds (phenylpropanoids, eleuterosides, flavonoids, phenolic acids, anthocyanins, vitamins, etc.). activates body’s protection mechanisms, directly affecting tissue metabolism. It increases mental physical performance, immunity, protects from stress, making use important in sports medicine military. food dietary supplements has become popular recent years, whereas some studies suggest that potential benefits reduction stress enhancement immune system function. Objective: To study content main raw material (leaves) senticosus, cultivated outdoor hydroponics soil conditions during different stages growth development. Methods: spectrophotometric method was determine total phenols, acids eleutherosides 70 % water-alcohol extract dry leaves at phases vegetation period. spectra were recorded using an Agilent Cary 60 UV-Vis spectrophotometer. Moreover, extractive substances determined, vitamin C, β-carotene fresh (State Pharmacopoeia 2015).Results:The results our showed levels obtained culture highest flowering phase (August-September). observed period, 1.3 times higher, flavonoids - 1.2 higher compared vegetative phase. worth noting “C”, extractives also Hydroponic plants had β-carotene, extractives, respectively by 1.4, plants. This could be due several factors such optimal nutrients (N=200 mg/L, P=65 K=350 mg/L), high oxygen hydroponic system. Conclusion: According phytochemical grown Ararat Valley, (eleutherosides, vitamins) general, research practical importance,since can source for production supplements. Keywords:biologically compounds, adaptogen, eleutherosides,

Язык: Английский

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Besin Sinerjisi ve Sinerjik Besinlerin Sağlık Üzerine Etkileri

Akdeniz Medical Journal, Год журнала: 2025, Номер 11(1), С. 140 - 148

Опубликована: Янв. 24, 2025

ÖZ Besinler, yaşamın devamlılığı için gerekli enerjinin sağlamasında görevlidir. Besinlerin yapısında bulunan besin ögeleri ve aktif bileşenler, sağlık üzerinde olumlu etkiler göstermektedir. Bu bileşenlerin eksikliği veya yetersizliği durumunda insan sağlığı olumsuz yönde etkilenmektedir. Besleyici değerinin ötesinde, faydalı etkileri olduğu bilinen besinler fonksiyonel olarak adlandırılmaktadır. Fonksiyonel besinler, hastalıkların önlenmesinde önemli bir rol oynamakla birlikte, gelecekte yapılacak araştırmalar büyük öneme sahiptir. Sinerjik kapsamında değerlendirilen, biyolojik birbiriyle etkileşimli ögeler içeren, koruyucu hastalıkları önleyici özelliklere sahip besinlerdir. Besin sinerjisi üzerine yapılan çalışmalar, besinin bileşenlerine diyetin tamamına odaklanarak, bu vücudundaki etkileşimlerini belirlemeyi amaçlamaktadır. Son yıllarda çeşitli besinlerin kombine edilmesi diyetlerin düzenlenmesiyle sinerjik etkinin oluşturulması yolla sağlığın korunması hedeflenmektedir. Besinler arasındaki etki, besinlerdeki biyoaktif maddelerin etkinliğini değiştirerek açısından sonuçlara neden olmaktadır. etkileşimler; karotenoidler, C vitamini demir gibi bileşenlerinin emilimini değiştirebilmekte, antioksidan kapasiteyi artırmakta, kan lipit profilini iyileştirmekte anti-kanserojen ögelerin artırabilmektedir. yüzden derleme, beslenme çalışmalarındaki kavramını etkilerini incelemektedir.

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The effect of squalene on proteinuria in patients with type 2 diabetes mellitus

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Год журнала: 2022, Номер 5(6), С. 117 - 117

Опубликована: Июнь 24, 2022

Background: Squalene, in recent years, has become a topic of interest to scientists due its potential health benefits and anti-inflammatory effects. Squalene is hydrocarbon belonging the triterpene class; it 30-carbon isoprenoid compound. In previous studies, amaranth oil, containing high amounts squalene, was shown function as an effective treatment option for reducing proteinuria, one key markers renal disease. Objectives: Our main goal understand effect squalene biotic agent proteinuria. order identify decreasing proteinuria we conducted experimental study on diabetic patients. research focused patients with type 2 diabetes mellitus separate dosages serum consumption. Over course 84 days, tracked changes levels based dosage consumed. addition this, testing also days various related parameters. These parameters include blood urea nitrogen (BUN), cystatin C, albumin, systolic diastolic pressure, transforming growth factor b1 (TGFB1). By assessing throughout study, hoped analyze relationship between these associated parameters.Methods: Five groups 30 people, totaling 150 volunteers, were recruited into study. group 1, healthy people served group. 2, T2DM did not consume any thereby serving control Group 3 consisted who consumed 200 mg (extracted from shark liver) daily. 4 400 Lastly, 5 600 3, 4, 5, prescribed total consecutive days. Among referred Vali-Asr medical laboratory (Tehran, Iran), 120 selected. Also, participated individuals. Regarding World Health Organization, inclusion criteria included following: fasting plasma glucose ≥ 126 mg/dL, glycated hemoglobin (HbA1c) 6.5%, taking corticosteroids. Informed consent obtained all volunteers. Results: Throughout decreased statistical significance. A positive correlation observed amount, there had been higher level decrease amount administered Statistical significance found well tested (BUN, Albumin (AL), creatinine (CR), TGFbeta1. Conclusion: All indicative alongside count showed trend overall reduction duration values vary time elapsed initial prescription. Based results, may be assumed that functions effectively reduce level.Keywords: disease, diabetes, functional food, oil

Язык: Английский

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Establishment of Dosage of Bioactive Compounds in Functional Food Products

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2022, Номер 2(3), С. 79 - 79

Опубликована: Март 29, 2022

As the prevalence of chronic diseases has increased in United States there also been an increase need for products that can help prevent, manage, or treat diseases. Functional food do this through components within them called bioactive compounds. These compounds provide multiple health benefits act on biomarkers disease. However, is not a set definition functional foods, making it hard to classify and regulate them. The Food Center proposed as well multi-step process their development. part compound identified product. To understand more about safety efficacy compound, appropriate dose must be established. find dose, clinical research conducted. In preclinical animal subjects are used identify critical amount compound. Researchers test concerns adverse effects from After this, trials performed human determine these different done drugs. quantum theory science needed create chain reaction leads claimed benefits. This researchers discover possible toxicities doses above amount. use mechanics industry could allow control physical characteristics bioavailability using nanotechnology. technology. Keywords: products, compounds, dosage, pre-clinical studies, sciences,

Язык: Английский

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The Effect of thyme, rosemary, and lemongrass oils on extension of the shelf life and qualitative characteristics of Iraqi soft cheese

Functional Foods in Health and Disease, Год журнала: 2024, Номер 14(1), С. 1 - 1

Опубликована: Янв. 4, 2024

Background: In the case of Iraqi soft cheeses, researchers have noted that moisture content these cheeses decreases over time in storage and reaches its maximum depletion final period. This information was found to be true for all samples were tested. As times increased, this decline followed by a rise ratio fat protein, which reached at 21 days under investigation. Additionally, research done on impact thyme, rosemary, lemongrass oil additions microbiological sensory properties cheese generated during storage. Objective: study set out ascertain adding oils such as chemical, microbial, white made from cow's milk stored 1 ± 5°C.Materials Methods: The wild thyme rosemary obtained local markets Baghdad, while one nurseries Abu Ghraib / Baghdad December 2022. essential extracted water distillation according method described. Results: went on, number Staphylococcus aureus bacteria increased; day 21, they 1.75, 3.54, 5.41, 6.75, 1.20, 2.14, 3.21, 4.20 CFU g cheese, respectively. largest count. By contrast, values dropped when added, coming down 1.54, 1.48, 2.10, 2.88 CFU/g sample quantity fell well, reaching 1.76, 2.88, 3.31 /g respectively, despite fact not present all. there no germs present, contrast had both coliform entirely missing. findings also demonstrated that, compared treated with oil, control sample, exhibited superior qualities, flavor, color, texture, bitterness various times.Keywords: Soft Cheese, Thyme Oil, Rosemary Lemongrass Chemical composition, Storage period

Язык: Английский

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Comparative analysis of functional components in Sakekasu (Sake lees)

Functional Foods in Health and Disease, Год журнала: 2024, Номер 14(1), С. 74 - 74

Опубликована: Янв. 16, 2024

Background:Sake lees (Sakekasu), a byproduct of sake production, has been recently attracting attention as functional food. Sakekasu is rich in nutrients and contains glycerophosphocholine (GPC) S-adenosylmethionine (SAM), which are well-known compounds. The content these compounds depends on variety factors, including fermentation conditions, especially the method length ripening. These differences reflected prominently color Sakekasu, becomes darker due to long ripening period high drying temperature. Objective: This study aimed clarify contents components with different tones (i.e., period).Methods:Three types (white, ocher, brawn) were collected from several breweries. multiple their extracts determined by liquid chromatography coupled resolution ion-trap/time-of-flight mass spectrometry.Results: white had more abundant GPC, SAM, fatty acids than those color. However, ethyl glucoside glyceryl glucosides did not differ significantly tone. Furthermore, Maillard reaction products sugar dipeptide mainly found dark-colored structures annotated tandem spectrometry.Conclusions:This clarified many relation tone period) highlighted potential food.Keywords: components, glycerophosphocholine, S-adenosylmethionine, spectrometer

Язык: Английский

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Anti-diabetic effect of a combination of black seed (Nigella sativa) and cumin (Cuminum cyminum), a two-step study from bench to bed

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2024, Номер 4(2)

Опубликована: Фев. 19, 2024

Background: Type 2 Diabetes mellitus (T2DM) is a prevalent chronic condition causing one-fifth million deaths globally. Standard treatments for diabetes are not sufficiently effective, highlighting the need to find adjunctive improve glycemic control. Nigella sativa (NS) and Cuminum cyminum (CC) two herbal medicines known their antioxidant, anti-inflammatory, antidiabetic properties. Objective: This study aims assess impact of supplementation with combination NS CC on regulation among individuals T2DM. The research was conducted in phases, pre-clinical clinical. Methods: In in-vivo phase, thirty-two male mice were allocated into four groups, each comprising eight mice. These groups categorized as follows: control, diabetic-type 2, diabetic-intervention-NS, diabetic-intervention-NS+CC. Following induction using Streptozotocin, NS-CC received 400 mg/kg/d or 360 oil plus 40 respectively 30 days. An insulin tolerance test (ITT), an intraperitoneal glucose (IPGTT), blood subsequently. clinical study, eighty patients who have been clinically diagnosed type randomly assigned distinct receive daily dosage 2000 mg soft gel sunflower 12 weeks. examination fasting (FBG) hemoglobin A1C (HbA1C) performed both before after completion intervention. Results: Preclinical findings exhibited notable decrease levels (decrease from 271.1±21.71 167.6±8.14 mg/dl) 275.4±25.57 136±13.07 mg/dl). Also, ITT IPGTT showed significantly more reduction compared non-treated diabetic group. Treating NS-CC, but alone decreased normal level no significant difference non-diabetic phase led greater mean sugar (FBS) (P=0.001) concentration HbA1C (P<0.001) placebo. Conclusions: may reduce resistance murine models Keywords: sativa, cyminum, mellitus, Glycemic Diabetic

Язык: Английский

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Polyphenol compounds of freeze-dried Moringa oleifera Lam pods and their anti-inflammatory effects on RAW 264.7 macrophages stimulated with lipopolysaccharide

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Год журнала: 2024, Номер 7(4), С. 185 - 198

Опубликована: Апрель 12, 2024

Background: Moringa oleifera pods are the main constituent in typical diets throughout Thailand. Due to their nutrients and phytochemicals, moringa have potential as an antioxidant anti-inflammatory agent. Freeze drying is a widely embraced method known for extending shelf life, resulting preserved high-quality products. Objective: This study aimed investigate physical properties, nutrients, bioactive compounds of freeze-dried well effects on lipopolysaccharide-induced Raw 264.7 macrophages. Methods: were ground. The powders extracted with 70% ethanol at room temperature 24 hr. then centrifuged 5000 rpm 25ᵒC. supernatant-filtered extracts collected determine compound contents properties. Results: results illustrated that pod extract had including genistein synthetic, trans-ferulic acid, p-Coumaric, myricetin, gallic syringic which demonstrated activity. In terms effects, 50-200 µg/ml inhibited pro-inflammatory mediators NO production IL-6 TNF-α levels LPS-induced These indicate properties make them promising new raw material functional product development. Keywords: Anti-inflammation, oleifera, acid.

Язык: Английский

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