Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials

Nutrients, Год журнала: 2024, Номер 16(9), С. 1352 - 1352

Опубликована: Апрель 30, 2024

In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed examine the efficacy psychobiotics—probiotics beneficial mental health via gut–brain axis—in adults with psychiatric and cognitive disorders. Out 51 studies involving 3353 patients where half received psychobiotics, there notably high measurement effectiveness specifically in treatment depression symptoms. Most participants were older female, treatments commonly utilizing strains Lactobacillus Bifidobacteria over periods ranging 4 24 weeks. Although general agreement on variability approaches presentations limits comparability generalization findings. This underscores need for more personalized optimization deeper investigation into mechanisms through which psychobiotics act. The research corroborates therapeutic potential represents progress management

Язык: Английский

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Influence of human gut microbiome on the healthy and the neurodegenerative aging

Experimental Gerontology, Год журнала: 2024, Номер 194, С. 112497 - 112497

Опубликована: Июнь 27, 2024

The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.

Язык: Английский

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Update on modifiable risk factors for Alzheimer's disease and related dementias

Current Opinion in Neurology, Год журнала: 2024, Номер 37(2), С. 166 - 181

Опубликована: Янв. 24, 2024

Purpose of review All human beings undergo a lifelong cumulative exposure to potentially preventable adverse factors such as toxins, infections, traumatisms, and cardiovascular risk factors, collectively termed exposome. The interplay between the individual's genetics exposome is thought have large impact in health outcomes cancer disease. Likewise, growing body evidence supporting idea that explain sizable proportion Alzheimer's disease related dementia (ADRD) cases. Recent findings Here, we will most recent epidemiological, experimental preclinical, interventional clinical studies examining some these modifiable for ADRD. We focus on new regarding air pollution, viral other infectious agents, traumatic brain injury, hearing loss. Summary While greater higher quality epidemiological needed unequivocally confirm their causal link with ADRD and/or unravel underlying mechanisms, may represent window opportunity reduce incidence prevalence at population level via screenings, education policies.

Язык: Английский

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Probiotics as modulators of gut-brain axis for cognitive development

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 20, 2024

Various microbial communities reside in the gastrointestinal tract of humans and play an important role immunity, digestion, drug metabolism, intestinal integrity, protection from pathogens. Recent studies have revealed that gut microbiota (GM) is involved communication with brain, through a bidirectional network known as gut-brain axis. This involves humoral, immunological, endocrine, neural pathways. Gut dysbiosis negatively impacts these pathways, leading to neurological complications cognitive deficits. Both pre-clinical clinical demonstrated probiotics can restore healthy GM, reduce pH, inflammation pathogenic microbes gut. Additionally, improve cell-to-cell signaling increase blood-brain-derived neurotrophic factors. Probiotics emerge potential approach for preventing managing Despite promising findings, safety concerns possible risks probiotic usage must be closely monitored addressed. review article provides brief overview significance health.

Язык: Английский

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Vascular dementia: From pathobiology to emerging perspectives

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102278 - 102278

Опубликована: Март 19, 2024

Vascular dementia (VaD) is the second most common type of dementia. VaD synonymous with ageing, and its symptoms place a significant burden on health wellbeing older people. Despite identification substantial number risk factors for VaD, pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, biogerontological imperative exists highlight modifiable lifestyle which can mitigate against developing VaD. This review will critically examine some have been revealed modulate risk. The survey commences by providing an overview putative are associated pathobiology Next, influence examined. Finally, emerging treatment avenues including epigenetics, gut microbiome, pro-longevity pharmaceuticals discussed. By drawing key evidence together, it our hope that used inform future experimental investigations in field.

Язык: Английский

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The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(8), С. 5771 - 5788

Опубликована: Июнь 28, 2024

Abstract Over the past decades, accumulating evidence suggests that gut microbiome exerts a key role in Alzheimer's disease (AD). The Association Workgroup is updating diagnostic criteria for AD, which changed profiles and categorization of biomarkers from “AT(N)” to “ATNIVS.” Previously, most studies focus on correlation between amyloid beta deposition (“A”), initial AD pathological feature triggering “downstream” tauopathy neurodegeneration. However, limited research investigated interactions other pathogenesis (“TNIVS”). In this review, we summarize current findings microbial characteristics whole spectrum AD. Then, describe association with updated biomarker categories pathogenesis. addition, outline microbiome‐related therapeutic strategies Finally, discuss issues field future directions. Highlights new revised (AD) proposed by have associations are described. Current summarized. Therapeutic based proposed.

Язык: Английский

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The interplay between gut microbiota composition and dementia

Reviews in the Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Recently, researchers have been interested in the potential connection between gut microbiota composition and various neuropsychological disorders. Dementia significantly affects socioeconomics of families. Gut is considered as a probable factor its pathogenesis. Multiple bacterial metabolites such short-chain fatty acids, lipopolysaccharides, neurotransmitters that are responsible for incidence progression dementia can be produced by microbiota. Various species Bifidobacterium breve , Akkermansia muciniphila Streptococcus thermophilus Escherichia coli Blautia hydrogenotrophica etc. implicated pathogenesis dementia. great target imitating or inhibiting their an adjunctive therapy based on role Therefore, some diets prevent decelerate altering composition. Moreover, probiotics modulate increasing beneficial bacteria reducing detrimental species. These therapeutic modalities novel methods probably safe effective. They enhance efficacy traditional medications improve cognitive function.

Язык: Английский

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Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review

Nutrients, Год журнала: 2025, Номер 17(3), С. 391 - 391

Опубликована: Янв. 22, 2025

Background/Objectives: This systematic review focused on collecting the most significant findings impact of administration Bifidobacterium infantis (or longum subps. infantis) and breve, alone, in conjunction, or combination with other strains, treatment neurodegenerative diseases including Alzheimer’s disease (AD) Parkinson’s (PD). These are characterized by progressive degeneration neurons, resulting a broad spectrum clinical manifestations. AD is typified decline cognitive abilities, while PD marked motor symptoms associated loss dopamine (DA). Methods: Five different databases, ScienceDirect, Scopus, Wiley, PubMed, Web Science (WoS), were reviewed studies screened for inclusion following criteria: (i) that specifically evaluated use infantis, subsp. breve as therapeutic intervention, either human animal models, context diseases; (ii) required to address one more pathologies examined this article, included, but not limited to, neurodegeneration, disease, oxidative stress; (iii) full text was accessible online; (iv) article written English. Results: The data suggest these probiotics have neuroprotective effects may delay progression. Conclusions: study provides updated insights into strains like PD, main limitation being number trials available.

Язык: Английский

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Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease

Nutrients, Год журнала: 2025, Номер 17(3), С. 558 - 558

Опубликована: Янв. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Язык: Английский

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The gut–organ axis: Clinical aspects and immune mechanisms

Allergology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

The gut-brain axis exemplifies the bidirectional connection between intestines and brain, as evidenced by impact of severe stress on gastrointestinal symptoms including abdominal pain diarrhea, conversely, influence discomfort mood. Clinical observations support notion connection, an increased prevalence inflammatory bowel disease (IBD) in patients with depression anxiety, well association changes gut microbiota neurological disorders such multiple sclerosis, Parkinson's disease, stroke Alzheimer's disease. brain communicate via complex mechanisms involving cytokines, immune cells, autonomic nerves, microbiota, which contribute to pathogenesis certain diseases. Two primary pathways mediate information exchange intestinal tract brain: signal transduction through bloodstream factors, bacterial metabolites neural pathways, neurotransmitters cytokines within nervous system interaction nerve cells beyond. In recent years, basic pathophysiology have been gradually elucidated. Beyond interaction, emerging evidence suggests extends other organs, liver lungs, intricate inter-organ communication pathways. An increasing number reports this clinical cross-organ interactions underscore potential for better understanding novel therapeutic strategies targeting inter-organs networks. Further clarification multiorgans premises transformative insights into strategies.

Язык: Английский

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