Follow-Up Period Affects the Association between Serum 25-Hydroxyvitamin D Concentration and Incidence of Dementia, Alzheimer’s Disease, and Cognitive Impairment
Опубликована: Авг. 14, 2024
Background/Objectives:
Vitamin
D’s
effect
on
risk
health
outcomes
is
often
evaluated
using
prospective
cohort
studies.
Risk
ratios
(RRs;
e.g.,
hazard
or
odds
ratios)
are
determined
for
incidence
participants
with
baseline
serum
25-hydroxyvitamin
D
[25(OH)D]
concentrations
below
above
specified
values.
Serum
25(OH)D
vary
over
time,
thereby
diluting
the
of
long
follow-up
periods.
Inverse
relationships
between
RR
and
period
have
been
reported
all-cause
mortality
rate
cancer
rates.
Here
I
evaluate
neurological
outcomes.
Methods:
analyzed
how
affected
results
from
10
studies
dementia,
6
Alzheimer’s
disease,
9
cognitive
impairment
respect
to
vitamin
deficiency.
Results:
For
impairment,
respectively,
linear
regression
fits
=
2.9
–
0.14
×
years,
r
0.73,
p
0.02;
0.69,
0.13;
1.8
0.066
0.72,
0.03.
The
fit
shortest
each
outcome
considered
best
estimate
deficiency’s
risk.
Those
values
approximately
twice
that
found
by
averaging
all
RRs
without
considering
period.
Conclusions:
conditions
should
be
relatively
short
periods
after
repeated
measurements
as
warranted
during
follow-up.
Язык: Английский
Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records
Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 16, 2025
Background:
Alzheimer's
disease
is
the
most
common
age-related
dementia.
Recent
compelling
evidence
from
previous
retrospective
electronic
health
record
(EHRs)
studies
suggests
that
herpes
simplex
virus
(HSV)
infections
may
be
a
risk
factor
for
developing
However,
no
age
and
propensity
score
matched
have
been
published
in
United
States
general
population
cohort
study
to
date.
Objective:
We
aimed
identify
whether
HSV
infection
shows
significantly
increased
of
development
dementia
sizable
heterogeneous
cohort.
investigated
type
1
(HSV1),
2
(HSV2),
or
coinfections
with
both
serotypes
pose
greater
across
different
biological
sexes
racial
groups.
Methods:
EHRs
patients
history
specific
(HSV1
HSV2)
were
selected
analysis.
These
records
compared
propensity-matched
control
group
analyzed
hazard
odds
ratios
through
TriNetX.
Results:
There
was
significant
difference
incidence
HSV-infected
versus
control.
Individuals
HSV,
HSV1,
HSV2,
coinfection
all
showed
controls.
Males
HSV2
are
at
higher
outcome
than
females
HSV2.
Conclusions:
While
consistent
reports,
these
findings
first
establish
who
any
diagnosis
using
nationwide,
population-based
States.
Язык: Английский
How follow-up period in prospective cohort studies affects the relationship between baseline fish consumption and risk of Alzheimer's disease and dementia
Journal of Alzheimer s Disease Reports,
Год журнала:
2025,
Номер
9
Опубликована: Янв. 1, 2025
Background
Diet
plays
an
important
role
in
the
risk
of
Alzheimer's
disease
(AD)
and
dementia.
Adherence
to
Mediterranean
diet
is
regarded
as
one
way
reduce
risk.
Fish
a
component
diet.
Participant
variables
change
with
time,
resulting
“regression
dilution”.
Objective
The
objective
investigate
follow-up
period
after
measurement
dietary
fish
intake
AD
Methods
A
recent
meta-analysis
prospective
cohort
studies
used
examine
this
effect
for
incidence
dementia
AD.
Results
For
seven
mean
periods
from
ten
years,
regression
fit
data
relative
(RR)
=
0.19
+
(0.087
×
Follow
up
[years],
r
0.84,
adjusted
2
0.66,
p
0.009).
However,
when
age
participants
was
added
analysis,
became
non-significant.
five
3.9
9.8
RR
0.11
(0.095
follow
[years]),
0.93,
0.87,
0.02).
shortest
are
40%
greater
than
standard
suggests
70%
Conclusions
Prospective
health
outcomes
should
reassess
every
few
years.
Meta-analyses
consider
during
up.
Язык: Английский
How Follow-Up Period in Prospective Cohort Studies Affects Relationship Between Baseline Serum 25(OH)D Concentration and Risk of Stroke and Major Cardiovascular Events
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3759 - 3759
Опубликована: Ноя. 1, 2024
Prospective
cohort
studies
are
useful
for
studying
how
biomolecular
status
affects
risk
of
adverse
health
outcomes.
Less
well
known
is
that
the
longer
follow-up
time,
lower
association
(or
"apparent
effect")
due
to
"regression
dilution".
Here,
we
evaluate
interval
from
baseline
"event"
relationship
between
serum
25-hydroxyvitamin
D
[25(OH)D]
concentration
and
later
incidence
stroke
major
cardiovascular
events
(MACEs).
Язык: Английский
Follow-Up Period Affects the Association between Serum 25-Hydroxyvitamin D Concentration and Incidence of Dementia, Alzheimer’s Disease, and Cognitive Impairment
Nutrients,
Год журнала:
2024,
Номер
16(18), С. 3211 - 3211
Опубликована: Сен. 23, 2024
Background/Objectives:
Vitamin
D’s
effect
on
risk
health
outcomes
is
often
evaluated
using
prospective
cohort
studies.
For
vitamin
D,
ratios
(RRs)
are
based
with
respect
to
serum
25-hydroxyvitamin
D
[25(OH)D]
concentrations
measured
at
time
of
enrollment.
Serum
25(OH)D
vary
over
time,
thereby
diluting
the
for
long
follow-up
periods.
Inverse
relationships
between
RR
and
period
have
been
reported
all-cause
mortality
rate
cancer
incidence
rates.
Here,
neurological
evaluated.
Methods:
The
analysis
examines
how
affected
results
from
nine
studies
dementia,
six
Alzheimer’s
disease,
cognitive
impairment
deficiency.
Results:
impairment,
respectively,
linear
regression
fits
=
2.9
−
0.14
×
years,
r
0.73,
p
0.02;
0.69,
0.13;
1.8
0.066
0.72,
0.03.
fit
shortest
each
outcome
considered
best
estimate
deficiency’s
risk.
Those
values
approximately
twice
that
found
by
averaging
all
RRs
without
considering
period.
Conclusions:
conditions
inversely
correlated
mean
in
This
should
be
design
such
Additional
also
conducted
regarding
raising
reduce
brain
function
decline.
Язык: Английский
Association Between Statin Use and Dementia, and Related Mechanisms: A Bibliometric Analysis from 2007 to 2023
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
unknown, С. 1 - 30
Опубликована: Сен. 11, 2024
Background:
Emerging
evidence
suggests
the
potential
of
hydroxymethylglutaryl-coenzyme
A
(HMG-CoA,
statins)
as
a
therapeutic
option
for
dementia.
Objective:
The
primary
objective
this
study
is
to
assess
current
state
research
on
statins
use
in
dementia,
with
focus
identifying
pivotal
questions
within
field.
Methods:
systemic
search
publications
statin
dementia
between
2007
and
2023
was
conducted,
utilizing
Web
Science
Core
Collection.
scientific
output
analyzed
from
various
perspectives
through
VOSviewer,
CiteSpace,
bibliometrics
website
(https://bibliometric.com/).
Results:
560
articles
authored
by
2,977
individuals
999
institutions
across
58
countries
were
included,
which
published
295
periodicals
cited
21,176
references
16,424
authors.
annual
publication
remained
steady,
while
number
citations
increased
consistently.
U.S.
Mayo
Clinic
emerged
most
significant
country
institution,
respectively.
B.
McGuinness
D.L.
Sparks
eminent
Journal
Alzheimer’s
Disease
influential
journal.
Three
sets
keywords
top
10
identified,
suggesting
Conclusions:
While
show
promising
treatment
their
remains
uncertain
due
reported
short-term
cognitive
impairment
events
questionable
long-term
protective
effects
against
question
ascertain
association
cognition.
mechanisms
underlying
cognition
are
multifaceted.
This
provides
insights
into
status
field
Язык: Английский