Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115283 - 115283
Опубликована: Март 16, 2024
Язык: Английский
Medicinal Research Reviews, Год журнала: 2024, Номер 44(4), С. 1596 - 1661
Опубликована: Фев. 1, 2024
Abstract Targeting actionable mutations in oncogene‐driven cancers and the evolution of immuno‐oncology are two prominent revolutions that have influenced cancer treatment paradigms caused emergence precision oncology. However, intertumoral intratumoral heterogeneity main challenges both fields treatment. In other words, finding a universal marker or pathway patients suffering from particular type is challenging. Therefore, targeting single hallmark with targeted therapeutic will not be efficient for fighting against tumor heterogeneity. Mesenchymal stem cells (MSCs) possess favorable characteristics cellular therapy, including their hypoimmune nature, inherent tumor‐tropism property, straightforward isolation, multilineage differentiation potential. MSCs can loaded various chemotherapeutics oncolytic viruses. The combination these intrinsic features possibility genetic manipulation makes them versatile delivery vehicle used vivo selective chemotherapeutic biological therapeutics. as biofactory local production chemical anticancer agents at site. MSC‐mediated immunotherapy could facilitate sustained release immunotherapeutic specifically site, allow achievement concentrations without need repetitive systemic administration high doses. Despite enthusiasm evoked by preclinical studies MSC therapy approaches, translation into clinical applications has faced serious challenges. This manuscript, critical viewpoint, reviewed evaluated tool gene immunotherapy, chemotherapy. Then, novel nanotechnology bioengineering approaches improve potency overcoming related to low localization sites discussed.
Язык: Английский
Процитировано
11
Nature Reviews Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
8
Biomaterials, Год журнала: 2022, Номер 291, С. 121876 - 121876
Опубликована: Окт. 28, 2022
Язык: Английский
Процитировано
33
Frontiers in Chemistry, Год журнала: 2023, Номер 11
Опубликована: Сен. 28, 2023
The use of biomaterials in delivering CRISPR/Cas9 for gene therapy infectious diseases holds tremendous potential. This innovative approach combines the advantages with protective properties biomaterials, enabling accurate and efficient editing while enhancing safety. Biomaterials play a vital role shielding components, such as lipid nanoparticles or viral vectors, from immunological processes degradation, extending their effectiveness. By utilizing flexibility tailored systems can be designed to address specific genetic diseases, paving way personalized therapeutics. Furthermore, this delivery method offers promising avenues combating illnesses by precisely modifying pathogen genomes, reducing pathogenicity. facilitate site-specific modifications, ensuring effective infected cells minimizing off-target effects. However, challenges remain, including optimizing efficiency, effects, long-term safety, establishing scalable production techniques. Thorough research, pre-clinical investigations, rigorous safety evaluations are imperative successful translation laboratory clinical applications. In review, we discussed how using revolutionizes disease treatment, offering precise safe capabilities potential significantly improve human health quality life.
Язык: Английский
Процитировано
21
Biochemical Pharmacology, Год журнала: 2023, Номер 212, С. 115555 - 115555
Опубликована: Апрель 18, 2023
Язык: Английский
Процитировано
17
Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(7), С. 373 - 373
Опубликована: Июль 17, 2023
Current radiologic and medication administration is systematic has widespread side effects; however, the of microbubbles nanobubbles (MNBs) possibility to provide therapeutic diagnostic information without same ramifications. Microbubbles (MBs), for instance, have been used ultrasound (US) imaging due their ability remain in vessels when exposed ultrasonic waves. On other hand, (NBs) can be further benefits, including chronic treatments osteoporosis cancer, gene delivery, treatment acute conditions, such as brain infections urinary tract (UTIs). Clinical trials are also being conducted different administrations utilizations MNBs. Overall, there large horizons benefits MNBs radiology, general medicine, surgery, many more medical applications. As such, this review aims evaluate most recent publications from 2016 2022 report current uses innovations
Язык: Английский
Процитировано
16
The Journal of Microbiology, Год журнала: 2024, Номер 62(7), С. 491 - 509
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
7
International Journal of Pharmaceutics, Год журнала: 2024, Номер 652, С. 123845 - 123845
Опубликована: Янв. 22, 2024
Язык: Английский
Процитировано
6
ChemBioChem, Год журнала: 2024, Номер 25(10)
Опубликована: Март 26, 2024
Abstract Split systems, modular entities enabling controlled biological processes, have become instrumental in research. This review highlights their utility across applications like gene regulation, protein interaction identification, and biosensor development. Covering significant progress over the last decade, it revisits traditional split proteins such as GFP, luciferase, inteins, explores advancements technologies Cas base editors. We also examine reassembly modules diverse fields, from regulation to therapeutic innovation. offers a comprehensive perspective on recent evolution of systems
Язык: Английский
Процитировано
6
Functional & Integrative Genomics, Год журнала: 2024, Номер 24(5)
Опубликована: Сен. 18, 2024
Язык: Английский
Процитировано
6