Abstract
Male
genitourinary
dysfunction
causes
serious
physical
or
mental
distress,
such
as
infertility
and
psychological
harm,
which
leads
to
impaired
quality
of
life.
Current
conventional
treatments
involving
drug
therapy,
surgical
repair,
tissue
grafting
have
a
limited
effect
on
recovering
the
function
fertility
organs.
To
address
these
limitations,
various
biomaterials
been
explored,
with
collagen-based
materials
increasingly
gaining
attention
for
reconstructing
male
system
due
their
superior
biocompatibility,
biodegradability,
low
antigenicity,
biomimetic
3D
matrix
characteristics,
hemostatic
efficacy,
regeneration
capabilities.
This
review
covers
recent
biomedical
applications
including
treatment
erectile
dysfunction,
premature
ejaculation,
penile
girth
enlargement,
prostate
cancer,
Peyronie's
disease,
chronic
kidney
etc.
Although
there
are
relatively
few
clinical
trials,
promising
results
existing
studies
animal
models
reveal
bright
future
in
diseases.
Graphic
Materials,
Год журнала:
2024,
Номер
17(23), С. 5770 - 5770
Опубликована: Ноя. 25, 2024
Chitosan,
a
natural
biopolymer
with
excellent
biocompatibility,
biodegradability,
and
modifiable
structure,
has
broad
applications
in
regenerative
medicine,
tissue
engineering,
food
packaging,
environmental
technology.
Its
abundance,
solubility
acidic
solutions,
capacity
for
chemical
modification
make
it
highly
adaptable
creating
specialized
derivatives
enhanced
properties.
Recent
advances
have
demonstrated
chitosan's
efficacy
composite
systems
regeneration,
drug
delivery,
antimicrobial
applications.
This
review
examines
unique
properties,
focus
on
its
antibacterial
activity
as
influenced
by
factors
like
pH,
concentration,
molecular
weight,
deacetylation
degree.
Additionally,
potential
sustainable,
non-toxic
material
eco-friendly
packaging
water
treatment
is
explored,
highlighting
the
growing
interest
chitosan
composites
other
polymers
metallic
nanoparticles
biomedical
Globally,
people
widely
recognize
cancer
as
one
of
the
most
lethal
diseases
due
to
its
high
mortality
rates
and
lack
effective
treatment
options.
Ongoing
research
into
therapies
remains
a
critical
area
inquiry,
holding
significant
social
relevance.
Currently
used
treatment,
such
chemotherapy,
radiation,
or
surgery,
often
suffers
from
other
problems
like
damaging
side
effects,
inaccuracy,
ability
clear
tumors.
Conventional
are
usually
imprecise
ineffective
develop
resistance
treatments
recurs.
Cancer
patients
need
fresh
innovative
that
can
reduce
effects
while
maximizing
effectiveness.
In
recent
decades
several
breakthroughs
in
these,
areas
medical
research,
have
paved
way
for
new
avenues
fighting
including
more
focused
alternatives.
This
study
reviews
exciting
possibilities
mesenchymal
stem
cells
(MSCs),
nanomaterials,
microbial
agents
modern
realm
treatment.
Nanoparticles
(NPs)
demonstrated
surprisingly
potential.
They
improve
drug
delivery
systems
(DDS)
significantly,
enhance
imaging
techniques
remarkably,
target
selectively
protecting
healthy
tissues.
MSCs
play
double
role
tissue
repair
vehicle
novel
gene
NPs
loaded
with
therapeutic
agents.
Additionally,
utilizing
agents,
particularly
those
involving
bacteria,
offer
an
inventive
approach
review
investigates
potential
MSCs,
addressing
shortcomings
conventional
therapies.
We
will
also
discuss
challenges
limitations
using
these
approaches.
Diabetology & Metabolic Syndrome,
Год журнала:
2024,
Номер
16(1)
Опубликована: Дек. 23, 2024
Obesity
is
a
multifactorial
condition
influenced
by
genetic,
environmental,
and
microbiome-related
factors.
The
gut
microbiome
plays
vital
role
in
maintaining
intestinal
health,
increasing
mucus
creation,
helping
the
epithelium
mend,
regulating
short-chain
fatty
acid
(SCFA)
production.
These
tasks
are
for
managing
metabolism
energy
balance.
Dysbiosis—an
imbalance
microbiome—leads
to
increased
appetite
rise
of
metabolic
disorders,
both
fuel
obesity
its
issues.
Furthermore,
childhood
connects
with
unique
shifts
microbiota
makeup.
For
instance,
there
surge
pro-inflammatory
bacteria
compared
children
who
not
obese.
Considering
intricate
nature
variety
microbiota,
additional
investigations
necessary
clarify
exact
involvement
beginnings
advancement
related
dilemmas.
Currently,
therapeutic
methods
like
probiotics,
prebiotics,
synbiotics,
fecal
transplantation
(FMT),
dietary
interventions
Mediterranean
ketogenic
diets,
physical
activity
show
potential
adjusting
fight
aid
weight
loss.
review
underscores
integration
microbial
metabolites
pharmacological
agents
such
as
orlistat
semaglutide
restoring
homeostasis.
However,
more
clinical
tests
essential
refine
doses,
frequency,
lasting
effectiveness
these
treatments.
This
narrative
overview
compiles
existing
knowledge
on
multifaceted
much
more,
showcasing
possible
treatment
strategies
addressing
health
challenges.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 24, 2025
Human
tissue
simulating
materials
are
currently
used
in
scientific
research
mainly
because
they
help
to
avoid
possible
ethical
issues,
unlike
what
happens
with
studies
involving
live
animals
and/or
human
cadavers.
The
use
of
ballistic
gelatin
as
a
soft
surrogate
stands
out,
although
other
types
can
be
used,
including
polyurethane
and
polydimethylsiloxane
the
simulation
bones
skin
respectively,
not
mention
some
computational
models
that
completely
replace
physical
for
gunshot
wound
simulation.
surrogates
useful
reconstructing
dynamics
crime
scene
when
important
forensic
traces
cannot
found.
In
absence
projectiles
but
possession
firearm
crime,
example,
it
is
verify
whether
weapon
question
actually
fired
fatal
by
comparing
injury
found
on
victim
produced
simulant
material
best
represents
anatomical
area
impacted,
indicated
literature.
Thus,
advances
experimental
terminal
ballistics
positively
impact
applied
sciences
search
better
technical
assistance
justice
system
solving
criminal
situations.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Март 18, 2025
Antibiotics
represent
one
of
the
most
significant
medical
breakthroughs
twentieth
century,
playing
a
critical
role
in
combating
bacterial
infections.
However,
rapid
emergence
antibiotic
resistance
has
become
major
global
health
crisis,
significantly
complicating
treatment
protocols.
This
paper
provides
narrative
review
current
state
resistance,
synthesizing
findings
from
primary
research
and
comprehensive
articles
to
examine
various
mechanisms
bacteria
employ
counteract
antibiotics.
One
sources
is
improper
use
antibiotics
livestock
industry.
The
drug-resistant
microorganisms
human
activities
industrial
production
presented
environmental
public
concerns.
Today,
resistant
nosocomial
infections
occur
following
long-term
hospitalization
patients,
causing
death
many
people,
so
there
an
urgent
need
for
alternative
treatments.
In
response
this
non-antibiotic
therapeutic
strategies
have
been
proposed,
including
bacteriophages,
probiotics,
postbiotics,
synbiotics,
fecal
microbiota
transplantation
(FMT),
nanoparticles
(NPs),
antimicrobial
peptides
(AMPs),
antibodies,
traditional
medicines,
toxin-antitoxin
(TA)
system.
While
these
approaches
offer
innovative
solutions
addressing
preserving
efficacy
therapies,
challenges
such
as
safety,
cost-effectiveness,
regulatory
hurdles,
large-scale
implementation
remain.
examines
potential
limitations
strategies,
offering
balanced
perspective
on
their
managing
mitigating
broader
impact
resistance.
Micromachines,
Год журнала:
2025,
Номер
16(4), С. 419 - 419
Опубликована: Март 31, 2025
The
rapid
evolution
of
micro-
and
nano-architectures
is
revolutionizing
biomedical
engineering,
particularly
in
the
fields
therapeutic
diagnostic
micromechanics.
This
review
explores
recent
innovations
nanostructured
materials
their
transformative
impact
on
healthcare
applications,
ranging
from
drug
delivery
tissue
engineering
to
biosensing
diagnostics.
Key
advances
fabrication
techniques,
such
as
lithography,
3D
printing,
self-assembly,
have
enabled
unprecedented
control
over
material
properties
functionalities
at
microscopic
scales.
These
engineered
architectures
offer
enhanced
precision
targeting
controlled
release
delivery,
foster
cellular
interactions
improve
sensitivity
specificity
devices.
We
examine
critical
design
parameters,
including
biocompatibility,
mechanical
resilience,
scalability,
which
influence
clinical
efficacy
long-term
stability.
also
highlights
translational
potential
current
limitations
bringing
these
laboratory
research
practical
applications.
By
providing
a
comprehensive
overview
trends,
challenges,
future
perspectives,
this
article
aims
inform
inspire
further
development
that
hold
promise
for
advancing
personalized
medicine.
