Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 633 - 633
Опубликована: Фев. 20, 2023
Prostate
cancer
(PC)
is
a
common
malignancy
and
one
of
the
leading
causes
cancer-related
death
in
men
worldwide.
Osteosarcoma
(OS)
most
bone
cancer,
representing
20–40%
all
cases.
Cancer
metastasis
process
by
which
malignant
tumor
cells
detach
from
primary
site
via
cascade
processes
migrate
to
secondary
sites
through
blood
circulation
or
lymphatic
system
colonize
form
tumors.
PC
has
specific
affinity
based
on
“seed
soil”
theory;
once
reach
bone,
it
becomes
incurable.
Several
studies
have
identified
long
noncoding
RNAs
(lncRNAs)
as
potential
targets
for
therapy
diagnostic
prognostic
biomarkers.
The
dysregulation
various
lncRNAs
been
found
types,
including
PC,
OS,
metastasis.
However,
mechanisms
underlying
lncRNA
oncogenic
activity
progression
are
extremely
complex
remain
incompletely
understood.
Therefore,
understanding
their
role
mechanism
may
help
better
manage
treat
this
malignancy.
aim
review
summarize
current
knowledge
involvement
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
154, С. 113609 - 113609
Опубликована: Авг. 27, 2022
Epigenetic
factors
are
critical
regulators
of
biological
and
pathological
mechanisms
they
could
interact
with
different
molecular
pathways.
Targeting
epigenetic
has
been
an
idea
approach
in
disease
therapy,
especially
cancer.
Accumulating
evidence
highlighted
function
long
non-coding
RNAs
(lncRNAs)
as
cancer
initiation
development
focused
on
their
association
downstream
targets.
microRNAs
(miRNAs)
the
most
well-known
targets
lncRNAs
present
review
focuses
lncRNA-miRNA
axis
malignancy
therapy
resistance
tumors.
LncRNA-miRNA
regulates
cell
death
such
apoptosis
autophagy
cancers.
This
affects
tumor
metastasis
via
regulating
EMT
MMPs.
Besides,
determines
sensitivity
cells
to
chemotherapy,
radiotherapy
immunotherapy.
Based
studies,
can
be
affected
by
drugs
genetic
tools
this
may
affect
expression
level
miRNAs
targets,
leading
suppression/progression.
LncRNAs
have
both
tumor-promoting
tumor-suppressor
functions
unique
complicated
implication
therapy.
also
other
signaling
networks
PI3K/Akt,
STAT3,
Wnt/β-catenin
EZH2
among
others.
Notably,
lncRNA/miRNA
considered
a
signature
for
diagnosis
prognosis
Non-coding RNA Research,
Год журнала:
2022,
Номер
8(2), С. 135 - 145
Опубликована: Дек. 14, 2022
Bladder
cancer
is
a
common
disease
associated
with
high
rates
of
morbidity
and
mortality.
Although
immunotherapy
approaches
such
as
adoptive
T-cell
therapy
immune
checkpoint
blockade
have
been
investigated
for
the
treatment
bladder
cancer,
their
off-target
effects
ability
to
affect
only
single
targets
led
clinical
outcomes
that
are
far
from
satisfactory.
Therefore,
it
important
identify
novel
can
effectively
control
tumor
growth
metastasis.
It
well
known
long
noncoding
RNAs
(lncRNAs)
powerful
regulators
gene
expression.
Increasing
evidence
has
shown
dysregulated
lncRNAs
in
involved
cell
proliferation,
migration,
invasion,
apoptosis,
epithelial-mesenchymal
transition
(EMT).
In
this
review,
we
focus
on
roles
underlying
mechanisms
lncRNA-mediated
competing
endogenous
RNA
(ceRNA)
networks
regulation
progression.
addition,
discuss
potential
targeting
ceRNA
overcome
resistance
its
association
clinicopathological
features
patients.
We
hope
review
will
stimulate
research
develop
more
effective
therapeutic
treatment.
Journal of Ovarian Research,
Год журнала:
2023,
Номер
16(1)
Опубликована: Фев. 18, 2023
Premature
ovarian
insufficiency
(POI)
is
one
of
the
common
women
reproductive
endocrine
diseases
which
adversely
impacts
female
fertility,
but
etiology
and
pathogenesis
still
remain
elusive.
Recently
increasing
researches
focus
on
roles
lncRNA
in
POI.
LncRNA
DANCR
was
involved
cell
differentiation
multiple
cancers.
It's
highly
expressed
ovary
while
role
POI
unknown.Here,
we
identify
a
new
related
DANCR,
negatively
contributes
to
granulosa
cells
aging
follicular
atresia.
proved
be
decreasingly
patients'
cells.
Additionally,
Dancr
knockout
(Dancr-/-)
mice
were
constructed
characterized
with
phenotypes
fertility
decline,
compared
Dancr+/+
mice.
Further,
vitro
experiments
indicated
that
knockdown
led
series
aging-related
changes
including
proliferation
inhibition,
cycle
G1
arrest
DNA
damage.
Mechanism
research
revealed
binds
hNRNPC
p53,
attenuates
binding
thus
enhancing
protein
level
p53
promoting
significantly.The
newly
identified
inhibits
p53-dependent
by
regulating
hNRNPC-p53
interaction,
eventually
counteracting
This
provides
insights
into
potential
target
for
future
diagnosis
treatment.
Environmental Toxicology,
Год журнала:
2023,
Номер
38(9), С. 2228 - 2239
Опубликована: Июнь 13, 2023
Abstract
Background
This
study
attempted
to
investigate
the
role
of
exosome
ELFN1‐AS1
in
gastric
cancer
(GC).
Methods
The
used
various
techniques
determine
level
exosomal
GC
tissue
and
cells,
including
quantitative
real‐time
PCR
.
Pull‐down
assay
dual‐luciferase
reporter
were
employed
identify
interactions
between
miR‐4644,
as
well
miR‐4644
PKM.
Western
blot
was
explore
potential
regulatory
mechanism.
Several
vitro
assays
conducted
xenograft
models
impacts
on
development,
metastasis
macrophage
polarization.
Results
upregulated
with
high
enrichment
GC‐derived
exosomes.
Exosomal
enhances
cell
abilities
stemness
GC.
targeted
regulated
which
triggered
PKM
expression.
modulated
glycolysis
via
an
HIF‐1α
dependent
manner
GC,
promoting
M2
polarization
recruitment.
Furthermore,
enhanced
growth,
vivo.
Conclusions
suggests
that
could
be
a
promising
biomarker
for
diagnosis
treatment
Molecules,
Год журнала:
2024,
Номер
29(10), С. 2402 - 2402
Опубликована: Май 20, 2024
Oral
cancer
(OC)
is
among
the
most
common
malignancies
in
world.
Despite
advances
therapy,
worst-case
scenario
for
OC
remains
metastasis,
with
a
50%
survival
rate.
Therefore,
it
critical
to
comprehend
pathophysiology
of
condition
and
create
diagnostic
treatment
plans
OC.
The
development
high-throughput
genome
sequencing
has
revealed
that
over
90%
human
encodes
non-coding
transcripts,
or
transcripts
do
not
code
any
proteins.
This
paper
describes
function
these
different
kinds
RNAs
(ncRNAs)
as
well
their
intriguing
therapeutic
potential.
onset
OC,
resistance,
are
linked
dysregulated
ncRNA
expression.
These
ncRNAs’
potentially
significant
roles
diagnosis
prognosis
have
been
suggested
by
differing
expression
blood
saliva.
We
outlined
every
promising
feature
ncRNAs
this
study.
Cancers,
Год журнала:
2023,
Номер
15(15), С. 3752 - 3752
Опубликована: Июль 25, 2023
Oral
cancer
(OC)
is
among
the
most
prevalent
cancers
in
world.
Certain
geographical
areas
are
disproportionately
affected
by
OC
cases
due
to
regional
differences
dietary
habits,
tobacco
and
alcohol
consumption.
However,
conventional
therapeutic
methods
do
not
yield
satisfying
treatment
outcomes.
Thus,
there
an
urgent
need
understand
disease
process
develop
diagnostic
strategies
for
OC.
In
this
review,
we
discuss
role
of
various
types
ncRNAs
OC,
their
promising
clinical
implications
as
prognostic
or
markers
targets.
MicroRNA
(miRNA),
long
ncRNA
(lncRNA),
circular
RNA
(circRNA),
PIWI-interacting
(piRNA),
small
nucleolar
(snoRNA)
major
whose
involvement
emerging.
Dysregulated
expression
ncRNAs,
particularly
miRNAs,
lncRNAs,
circRNAs,
linked
with
initiation,
progression,
well
therapy
resistance
via
modulation
a
series
cellular
pathways
through
epigenetic,
transcriptional,
post-transcriptional,
translational
modifications.
Differential
expressions
miRNAs
lncRNAs
blood,
saliva
extracellular
vesicles
have
indicated
potential
importance.
summarized
all
aspects
management
APOPTOSIS,
Год журнала:
2023,
Номер
28(7-8), С. 1035 - 1047
Опубликована: Апрель 15, 2023
Abstract
Internal
tandem
duplication
(ITD)
is
the
most
common
type
of
FLT3
mutation
(FLT3-ITD),
accounting
for
about
25%
AML
patients.
The
expression
DANCR
in
FLT3-ITD
had
not
been
paid
attention
to,
and
whether
its
regulatory
relationship
with
IGF2BP2
can
affect
progression
was
unclear.
Our
study
sought
to
verify
biological
role
as
an
m6A
reading
protein
AML.
To
further
explore
mechanism
AML,
provide
a
basis
screening
biomarkers
development
targeted
drugs.
results
show
that
upregulated
FLT3-ITD+
patients
cells.
Si-IGF2BP2
could
inhibit
proliferation,
glycolytic
promote
apoptosis
MV4-11
RNA
stability.
This
discovery
will
new
horizons
early
therapy
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
Год журнала:
2024,
Номер
32(10), С. 1589 - 1612
Опубликована: Янв. 1, 2024
Oral
squamous
cell
carcinoma
(OSCC)
is
one
of
the
most
prevalent
forms
head
and
neck
carcinomas
(HNSCC)
with
a
poor
overall
survival
rate
(about
50%),
particularly
in
cases
metastasis.
RNA-based
cancer
biomarkers
are
relatively
advanced
concept,
non-coding
RNAs
currently
have
shown
promising
roles
detection
treatment
various
malignancies.
This
review
underlines
function
long
(lncRNAs)
OSCC
its
subsequent
clinical
implications.
LncRNAs,
class
RNAs,
larger
than
200
nucleotides
resemble
mRNA
numerous
ways.
However,
unlike
mRNA,
lncRNA
regulates
multiple
druggable
non-druggable
signaling
molecules
through
simultaneous
interaction
DNA,
RNA,
proteins,
or
microRNAs
depending
on
concentration
localization
cells.
Upregulation
oncogenic
lncRNAs
down-regulation
tumor
suppressor
evident
tissues
body
fluids
such
as
blood
saliva
indicating
their
potential
valuable
biomarkers.
Targeted
inhibition
candidate
over-expression
showed
therapeutic
