International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11799 - 11799
Опубликована: Ноя. 2, 2024
Osteoarthritis
(OA),
a
common
and
disabling
degenerative
joint
disease,
affects
millions
of
people
worldwide
imposes
considerable
burden
on
patients
society
due
to
its
high
prevalence
economic
costs.
The
pathogenesis
OA
is
closely
related
the
progressive
degradation
articular
cartilage
accompany
inflammation;
however,
itself
cannot
heal
modulate
inflammation
lack
nerves,
blood
vessels,
lymph-vessels.
Therefore,
reliable
effective
methods
treat
remain
highly
desired.
Local
administration
drugs
or
bioactive
materials
by
intra-articular
injection
delivery
system
represents
promising
approach
OA,
especially
considering
prolonged
retention,
chondrocytes
targeting,
stimuli-responsive
release
achieve
precision
therapy.
This
article
summarizes
discusses
advances
in
currently
used
systems
(nanoparticle,
hydrogel,
liposome,
microsphere)
then
focuses
their
applications
treatment
from
perspective
endogenous
stimulus
(redox
reactions,
pH,
enzymes,
temperature)
exogenous
(near-infrared,
magnetic,
ultrasound)-responsive
release.
Finally,
challenges
potential
future
directions
for
development
nano-delivery
are
summarized.
Polymers,
Год журнала:
2025,
Номер
17(7), С. 975 - 975
Опубликована: Апрель 3, 2025
Traumatic
or
degenerative
defects
of
articular
cartilage
impair
joint
function,
and
the
treatment
damage
remains
a
challenge.
By
mimicking
extracellular
matrix
(ECM),
exosome-seeded
cryogels
may
enhance
cell
proliferation
chondral
repair.
ECM-based
were
cryopolymerized
with
gelatin,
chondroitin
sulfate,
various
concentrations
(0%,
0.3%,
0.5%,
1%)
hyaluronic
acid
(HA),
their
water
content,
swelling
ratio,
porosity,
mechanical
properties,
effects
on
viability
evaluated.
The
regenerative
bone
marrow-derived
mesenchymal
stem
(BM-MSC)-derived
exosome
(at
concentration
106
particles/mL)-seeded
0.3%
HA
assessed
in
vitro
surgically
induced
male
New
Zealand
rabbit
vivo.
porosity
significantly
(p
<
0.05)
increased
Young's
modulus
values
decreased
increasing
concentrations.
MTT
assays
revealed
that
developed
biomaterials
had
no
cytotoxic
effects.
optimal
cryogel
composition
was
HA,
resulting
favorable
properties
suitable
strength.
Exosomes
alone
promoted
chondrocyte
(with
optical
densities
58%
51%
greater
than
control).
facilitated
ECM
deposition
sulfated
glycosaminoglycan
synthesis.
Although
we
observed
repair
via
Alcian
blue
staining
both
cryogel,
layered
arrangement
chondrocytes
superior
to
control
when
used.
This
study
potential
value
using
BM-MSC-derived
for
tissue
engineering
treat
injury.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 28, 2023
With
the
increase
in
human
lifespan
and
aggravation
of
global
aging,
incidence
osteoarthritis
(OA)
is
increasing
annually.
To
better
manage
control
progression
OA,
prompt
diagnosis
treatment
for
early-stage
OA
are
important.
However,
a
sensitive
diagnostic
modality
therapy
early
have
not
been
well
developed.
The
exosome
class
extracellular
vesicles
containing
bioactive
substances,
that
can
be
delivered
directly
from
original
cells
to
neighboring
modulate
cellular
activities
through
intercellular
communication.
In
recent
years,
exosomes
considered
important
OA.
Synovial
fluid
its
encapsulated
e.g.,
microRNA,
lncRNA,
proteins,
only
distinguish
stages
but
also
prevent
by
targeting
cartilage
or
indirectly
modulating
immune
microenvironment
joints.
this
mini-review,
we
include
studies
on
therapeutic
modalities
hope
provide
new
direction
disease
future.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 220 - 220
Опубликована: Янв. 9, 2023
Bone-related
diseases
are
major
problems
and
heavy
burdens
faced
by
modern
society.
Current
clinical
approaches
for
the
treatment
of
these
pathological
conditions
often
lead
to
complications
have
limited
therapeutic
efficacy.
In
this
context,
development
nanotherapeutic
platforms,
such
as
extracellular
vesicles,
can
improve
relevant
effects.
particular,
exosomes
nano-sized,
lipid
bilayer
vesicles
secreted
many
cells
in
mammals.
Due
their
innate
capacity
transport
materials—including
proteins,
lipids,
genes—among
cells,
well
attraction
target
they
considered
be
a
crucial
medium
cell
communication
involved
number
biological
processes.
Exosomes
been
used
drug
delivery
vehicles
recent
bone
tissue
engineering
studies,
order
regulate
homeostasis.
However,
precise
workings
exosome
regulatory
network
maintaining
homeostasis
its
potential
treating
injury
remain
unclear.
To
provide
fresh
perspective
study
bone-related
diseases,
paper,
we
review
studies
on
roles
composition
characteristics
aiming
new
ideas
application
diseases.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Фев. 21, 2024
Osteoarthritis
(OA)
is
a
degenerative
disease
of
cartilage
that
affects
the
quality
life
and
has
increased
in
morbidity
mortality
recent
years.
Cartilage
homeostasis
dysregulation
are
thought
to
be
important
mechanisms
involved
development
OA.
Many
studies
suggest
lncRNAs
OA
can
used
diagnose
or
treat
Among
existing
therapeutic
regimens,
drug-and
nondrug-mediated
expected
improve
mechanism
adverse
effects
drug
resistance.
Moreover,
targeted
lncRNA
therapy
may
also
prevent
The
purpose
this
review
summarize
links
between
In
addition,
we
potential
applications
at
multiple
levels
adjuvant
therapies.
This
highlights
targeting
novel
strategy
for
improving
modulating
patients.
Musculoskeletal
injuries
such
as
equine
osteoarthritis,
osteoarticular
defects,
tendonitis/desmitis,
and
muscular
disorders
are
prevalent
among
sport
horses,
with
a
fair
prognosis
for
returning
to
exercise
or
previous
performance
levels.
The
field
of
medicine
has
witnessed
rapid
fruitful
development,
resulting
in
diverse
range
therapeutic
options
musculoskeletal
problems.
Staying
abreast
these
advancements
can
be
challenging,
prompting
the
need
comprehensive
review
commonly
used
recent
treatments.
aim
is
compile
current
managing
injuries,
spanning
from
simple
complex
physiotherapy
techniques,
conservative
treatments
including
steroidal
non-steroidal
anti-inflammatory
drugs,
hyaluronic
acid,
polyacrylamides,
promising
regenerative
therapies
hemoderivatives
stem
cell-based
therapies.
Each
modality
scrutinized
its
benefits,
limitations,
potential
synergistic
actions
facilitate
their
most
effective
application
intended
healing/regeneration
injured
tissue/organ
subsequent
patient
recovery.
While
emerge
particularly
multidisciplinary
approach
underscored
throughout
discussion,
emphasizing
importance
considering
various
modalities
tandem.
Biotechnology Journal,
Год журнала:
2025,
Номер
20(4)
Опубликована: Апрель 1, 2025
Osteoarthritis
(OA)
is
a
cartilage-degenerative
joint
disease.
Mitophagy
impacts
articular
cartilage
damage.
tRNA-derived
small
RNAs
(tsRNAs)
are
one
of
the
contents
adipose
mesenchymal
stem
cell
(AMSC)-derived
exosomes
(AMSC-exos)
and
involved
in
disease
progression.
However,
whether
tsRNAs
regulate
mitophagy
tsRNA-modified
AMSC-exos
improve
OA
via
remain
unclear.
We
performed
RNA
sequencing
to
identify
OA-related
tsRNAs,
which
were
then
loaded
into
AMSC-exos,
exploring
function
mechanisms
related
vitro
vivo.
Overall,
53
differentially
expressed
(DEtsRNAs)
identified
between
normal
tissues,
among
42
DEtsRNAs,
including
tsRNA-12391,
downregulated
group.
Target
genes
tsRNA-12391
mainly
participated
mitophagy-related
pathways
such
as
Rap1
signaling
pathway.
Compared
control
group,
mimics
significantly
promoted
mitophagy,
shown
by
upregulated
expression
PINK1
LC3
co-localization
Mito-Tracker
Green
PINK1.
Furthermore,
effectively
enhanced
chondrogenesis
chondrocytes,
demonstrated
elevated
collagen
II
ACAN.
with
overexpression
also
facilitated
Mechanistically,
bound
ATAD3A
restricted
ATAD31
from
degrading
PINK1,
leading
accumulation.
reversed
effects
on
chondrogenesis.
interacting
ATAD31;
this
may
be
novel
therapeutic
strategy
for
OA.
