Joint Bone Spine, Год журнала: 2023, Номер 91(2), С. 105640 - 105640
Опубликована: Сен. 20, 2023
Язык: Английский
Clinical Rheumatology, Год журнала: 2024, Номер 43(3), С. 1189 - 1197
Опубликована: Янв. 30, 2024
Abstract This study aimed to report the most current data on incidence and disability-adjusted life years (DALY) associated with osteoarthritis in China from 1990 2019. Publicly available modelled Global Burden of Disease Study (GBD) 2019 were used. The DALY, due China, stratified by sex, trends risk factors, assess age, period, cohort effects long-term DALY We found that age-standardized rates are higher than average levels Asia, Africa, Oceania. In 2019, number cases was 10,681,311, an increase 132.66% compared 1990. 4,724,885 person-years, which 159.70% 750.96/100,000,332.19/100,000. High body-mass as factors for population attributable proportion (PAF) increasing steadily three types high low knee, hand, hip. Age–period–cohort model showed rate shows a trend first then decreasing age; concurrently, increased age. For period effect, we ratio ( RR ) kept born before 2005–2009, then, it gradually reduced year birth after 2005–2009. As almost has no change, while burden impact substantial increasing. Adopting suitable control preventive community measures reduce modifiable is needed future China. Key Points • paper analyzes disease time discusses influence perspectives .
Язык: Английский
Процитировано
16
Journal of Orthopaedic Translation, Год журнала: 2023, Номер 41, С. 54 - 62
Опубликована: Июль 1, 2023
Osteoarthritis (OA) poses a significant burden for countless individuals, inflicting relentless pain and impairing their quality of life. Although traditional treatments OA focus on management surgical interventions, they often fall short addressing the underlying cause disease. Fortunately, emerging biomaterial-based scaffolds offer hope therapy, providing immense promise cartilage regeneration in OA. These innovative are ingeniously designed to provide support mimic intricate structure natural extracellular matrix, thus stimulating damaged cartilage. In this comprehensive review, we summarize discuss current landscape Furthermore, delve into diverse range biomaterials employed construction explore cutting-edge techniques utilized fabrication. By examining both preclinical clinical studies, aim illuminate remarkable versatility untapped potential context thoroughly state research review provides valuable insights that bridge gap between scientific knowledge practical application. This is crucial clinicians researchers who strive develop go beyond symptom directly target Through analysis multidisciplinary approach, paves way translation applications, ultimately improving lives individuals suffering from shaping future orthopedic medicine.
Язык: Английский
Процитировано
33
npj Aging, Год журнала: 2025, Номер 11(1)
Опубликована: Фев. 3, 2025
Knee osteoarthritis (OA) has long been considered as a cartilage disease. However, it is now well established that defects are the ultimate OA feature only. Several studies investigating mechanisms of onset/progression have recognized infrapatellar fat pad an active OA-player but also possible source stem cells with regenerative potential for cartilage. Is really like that? cautious approach should be adopted.
Язык: Английский
Процитировано
1
Microchimica Acta, Год журнала: 2025, Номер 192(4)
Опубликована: Март 5, 2025
The review article provides a short introduction to exosomes with the focus use as disease markers itself (i.e. their concentration or presence of some specific receptors) source biomarkers such proteins and metabolites. In detail, we are discussing various methods exosome isolation main paper is on affinity capture exosomes, since them can be applied sub-populations produced by organs. comprehensive overview magnetic (bio)affinity detection exosomal cargo using different ligands antibodies, DNA aptamers, peptides, glycan-based recognition, transferrin-based approaches, based recognition phospholipids other approaches including electrostatic interactions. in detail key analytical clinical parameters form an extensive table summarising outcomes published last two years (2023-2024). Finally, also conclusions sections pros cons for and/or determination content.
Язык: Английский
Процитировано
1
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Апрель 18, 2024
Degenerative orthopaedic diseases pose a notable worldwide public health issue attributable to the global aging population. Conventional medical approaches, encompassing physical therapy, pharmaceutical interventions, and surgical methods, face obstacles in halting or reversing degenerative process. In recent times, exosome-based therapy has gained widespread acceptance popularity as an effective treatment for diseases. This therapeutic approach holds potential "cell-free" tissue regeneration. Exosomes, membranous vesicles resulting from fusion of intracellular multivesicles with cell membrane, are released into extracellular matrix. Addressing challenges such rapid elimination natural exosomes vivo limitation drug concentration can be effectively achieved through various strategies, including engineering modification, gene overexpression biomaterial binding. review provides concise overview source, classification, preparation methods exosomes, followed by in-depth analysis their functions applications. Furthermore, explores strategies utilizing diseases, overexpression, The primary objective is provide fresh viewpoint on utilization addressing bone conditions support practical application theranosis
Язык: Английский
Процитировано
6
Frontiers in Pediatrics, Год журнала: 2024, Номер 12
Опубликована: Апрель 24, 2024
Idiopathic scoliosis significantly affects the physical and mental health of children adolescents, with varying prevalence rates in different regions. The occurrence idiopathic is associated genetic regulation biochemical factors, but changes exosome-derived miRNA profiles among patients remain unclear. This study aimed to determine Yunnan Province, China, identify key miRNAs through a cohort study.
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2896 - 2896
Опубликована: Март 22, 2025
Links between cathepsin K and the pathophysiology of osteoarthritis (OA) can be established, not least because overabundance in serum OA patients upregulation degraded cartilage animal models OA. Chondrocytes, chondroclasts, or osteoclasts contribute to accumulated at diseased osteochondral junction. After a general presentation physiology, as well its degradation processes, we describe function effect on via type II collagen cleavage. An overview most promising inhibitors is then presented, together with their vitro effects. Although intensive research initially focused bone resorption, there growing interest potential these drugs prevent degradation. In this review, summarize pre-clinical clinical trials that support use treatment To date, no molecules are commercially available, although few have undergone trials, but believe development could broaden therapeutic arsenal for
Язык: Английский
Процитировано
0
Progress in Biophysics and Molecular Biology, Год журнала: 2024, Номер unknown
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
3
Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11
Опубликована: Июнь 6, 2024
Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such frequently result in complications are inadequately effective. Research has shifted from conventional based mesenchymal stem cells (MSCs) exosomes derived MSCs. Exosomes natural nanocarriers of endogenous DNA, RNA, proteins, lipids have low immune clearance rate good barrier penetration allow targeted delivery therapeutics. MSC-derived (MSC-exosomes) the characteristics both MSCs exosomes, so they can immunosuppressive tissue-regenerative effects. Despite advances our knowledge MSC-exosomes, their regulatory mechanisms functionalities unclear. Here we review therapeutic potential MSC-exosomes for skeletal diseases.
Язык: Английский
Процитировано
3
Chinese Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Июль 31, 2023
Abstract Osteoarthritis (OA) is a common chronic degenerative joint disease in clinical practice with high prevalence, especially the elderly. Traditional Chinese Medicine (TCM) believes that OA belongs to category of “Bi syndrome” and “bone Bi syndrome”. The etiology pathogenesis lie deficiency liver kidney, Qi blood, external exposure wind, cold, dampness. Epimedium yang-reinforcing herb TCM, which can tonify strengthen muscles bones, dispel cold dampness, treat both symptoms root cause In addition, contains large number ingredients. Through modern science technology, more than 270 compounds have been found , among flavonoids are main active Therefore, our study will review effects mechanisms genus treating from two aspects: (1) Introduction its ingredients; (2) Effects ingredients relevant signaling pathways, order provide ideas for treatment.
Язык: Английский
Процитировано
8