Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 84 - 84
Опубликована: Янв. 13, 2025
Sarcopenia
corresponds
to
a
decrease
in
muscle
mass
and
strength.
CCL5
is
new
myokine
whose
expression,
along
with
the
CCR5
receptor,
increased
sarcopenic
muscle.
Therefore,
we
evaluated
whether
induce
sarcopenic-like
effect
on
skeletal
tissue
cultured
cells.
Electroporation
tibialis
anterior
(TA)
of
mice
was
used
overexpress
CCL5.
The
TA
muscles
were
analyzed
by
measuring
fiber
diameter,
content
sarcomeric
proteins,
gene
expression
E3-ligases.
C2C12
myotubes
single-isolated
flexor
digitorum
brevis
(FDB)
fibers
also
treated
recombinant
(rCCL5).
participation
using
antagonist
maraviroc
(MVC).
Protein
structural
analyses
performed.
results
showed
that
overexpression
led
sarcopenia
reducing
strength
mass,
muscle-fiber
protein
content,
upregulating
same
phenotype
observed
FDB
fibers.
We
reactive
oxygen
species
(ROS)
production
carbonylated
denoting
oxidative
stress
induced
When
antagonized,
effects
produced
rCCL5
prevented.
In
conclusion,
report
for
first
time
novel
exerts
through
receptor.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 14, 2023
Abstract
The
ageing
process
is
a
systemic
decline
from
cellular
dysfunction
to
organ
degeneration,
with
more
predisposition
deteriorated
disorders.
Rejuvenation
refers
giving
aged
cells
or
organisms
youthful
characteristics
through
various
techniques,
such
as
reprogramming
and
epigenetic
regulation.
great
leaps
in
rejuvenation
prove
that
not
one-way
street,
many
rejuvenative
interventions
have
emerged
delay
even
reverse
the
process.
Defining
mechanism
by
which
roadblocks
signaling
inputs
influence
complex
programs
essential
for
understanding
developing
strategies.
Here,
we
discuss
intrinsic
extrinsic
factors
counteract
cell
rejuvenation,
targeted
core
mechanisms
involved
this
Then,
critically
summarize
latest
advances
state-of-art
strategies
of
rejuvenation.
Various
methods
also
provide
insights
treating
specific
ageing-related
diseases,
including
reprogramming,
removal
senescence
(SCs)
suppression
senescence-associated
secretory
phenotype
(SASP),
metabolic
manipulation,
stem
cells-associated
therapy,
dietary
restriction,
immune
heterochronic
transplantation,
etc.
potential
applications
therapy
extend
cancer
treatment.
Finally,
analyze
detail
therapeutic
opportunities
challenges
technology.
Deciphering
will
further
into
anti-ageing
disease
treatment
clinical
settings.
Biomedicines,
Год журнала:
2023,
Номер
11(1), С. 136 - 136
Опубликована: Янв. 5, 2023
Sarcopenia
is
a
multifactorial
condition
related
to
the
loss
of
muscle
mass
and
strength
due
aging,
eating
habits,
physical
inactivity,
or
even
caused
by
another
disease.
Affected
individuals
have
higher
risk
falls
may
be
associated
with
heart
disease,
respiratory
diseases,
cognitive
impairment,
consequently
an
increased
hospitalization,
in
addition
causing
economic
impact
high
cost
care
during
stay
hospitals.
The
standardization
appropriate
treatment
for
patients
sarcopenia
that
could
help
reduce
pathology-related
morbidity
necessary.
For
these
reasons,
this
study
aimed
perform
systematic
review
role
nutrition
drugs
ameliorate
health
quality
life
sarcopenic
PRISMA
guidelines
were
followed.
Lifestyle
interventions
shown
profound
on
but
using
supplements
different
can
also
skeletal
maintenance.
Creatine,
leucine,
branched-chain
amino
acids,
omega
3,
vitamin
D
show
benefits.
Although
controversial
results,
medications
such
as
Metformin,
GLP-1,
losartan,
statin,
growth
hormone,
dipeptidyl
peptidase
4
inhibitors
been
considered
alter
sarcopenic's
metabolic
parameters,
protect
against
cardiovascular
diseases
outcomes,
while
protecting
muscles.
Annals of Medicine,
Год журнала:
2023,
Номер
55(2)
Опубликована: Авг. 29, 2023
Aim:
To
discuss
the
progress
of
extracellular
matrix
(ECM)
characteristics,
mitochondrial
homeostasis,
and
their
potential
crosstalk
in
pathogenesis
sarcopenia,
a
geriatric
syndrome
characterized
by
generalized
progressive
reduction
muscle
mass,
strength,
physical
performance.Methods:
This
review
focuses
on
anatomy
physiology
skeletal
muscle,
alterations
ECM
mitochondria
during
ageing,
role
interplay
between
sarcopenia.Results:
Emerging
evidence
points
to
clear
various
tissues
organs.
Under
ageing
process,
undergoes
changes
composition
properties
that
may
mediate
via
systematic
metabolism,
ROS,
SPARC
pathway,
AMPK/PGC-1α
signalling,
which
turn
exacerbate
degeneration.
However,
precise
effects
such
pathobiology
particularly
have
not
yet
been
fully
understood.Conclusion:
The
are
partially
responsible
for
worsened
function
process.
A
deeper
understanding
interactions
sarcopenic
patients
can
help
prevent
sarcopenia
improve
its
prognoses.
Acta Physiologica,
Год журнала:
2024,
Номер
240(3)
Опубликована: Фев. 2, 2024
Abstract
Sarcopenia
lowers
the
quality‐of‐life
for
millions
of
people
across
world,
as
accelerated
loss
skeletal
muscle
mass
and
function
contributes
to
both
age‐
disease‐related
frailty.
Physical
activity
remains
only
proven
therapy
sarcopenia
date,
but
alternatives
are
much
sought
after
manage
this
progressive
disorder
in
individuals
who
unable
exercise.
Mitochondria
have
been
widely
implicated
etiology
increasingly
suggested
attractive
therapeutic
targets
help
restore
perturbed
balance
between
protein
synthesis
breakdown
that
underpins
atrophy.
Reviewing
current
literature,
we
note
mitochondrial
bioenergetic
changes
generally
interpreted
intrinsic
dysfunction
renders
cells
incapable
making
sufficient
ATP
fuel
synthesis.
Based
on
reported
effects
interventions,
however,
argue
observed
may
instead
reflect
an
adaptation
pathologically
decreased
energy
expenditure
sarcopenic
muscle.
Discrimination
these
mechanistic
possibilities
will
be
crucial
improving
management
sarcopenia.
Antioxidants,
Год журнала:
2024,
Номер
13(1), С. 86 - 86
Опубликована: Янв. 10, 2024
Tendinopathy
is
a
debilitating
condition
marked
by
degenerative
changes
in
the
tendons.
Its
complex
pathophysiology
involves
intrinsic,
extrinsic,
and
physiological
factors.
While
its
intrinsic
extrinsic
factors
have
been
extensively
studied,
role
of
factors,
such
as
hypoxia
oxidative
stress,
remains
largely
unexplored.
This
review
article
delves
into
contribution
hypoxia-associated
genes
oxidative-stress-related
to
tendon
degeneration,
offering
insights
potential
therapeutic
strategies.
The
unique
aspect
this
study
lies
pathway-based
evidence,
which
sheds
light
on
how
these
can
be
targeted
enhance
overall
health.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10535 - 10535
Опубликована: Сен. 30, 2024
Progress
made
by
the
medical
community
in
increasing
lifespans
comes
with
costs
of
incidence
and
prevalence
age-related
diseases,
neurodegenerative
ones
included.
Aging
is
associated
a
series
morphological
changes
at
tissue
cellular
levels
brain,
as
well
impairments
signaling
pathways
gene
transcription,
which
lead
to
synaptic
dysfunction
cognitive
decline.
Although
we
are
not
able
pinpoint
exact
differences
between
healthy
aging
neurodegeneration,
research
increasingly
highlights
involvement
neuroinflammation
chronic
systemic
inflammation
(inflammaging)
development
age-associated
via
pathogenic
cascades,
triggered
dysfunctions
circadian
clock,
gut
dysbiosis,
immunosenescence,
or
impaired
cholinergic
signaling.
In
addition,
gender
susceptibility
course
neurodegeneration
that
appear
be
mediated
glial
cells
emphasize
need
for
future
this
area
an
individualized
therapeutic
approach.
rejuvenation
still
its
very
early
infancy,
accumulated
knowledge
on
various
involved
promoting
senescence
opens
perspective
interfering
these
preventing
delaying
senescence.
