International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4152 - 4152
Опубликована: Апрель 27, 2025
Insulin
overdose
may
cause
hypoglycemic
encephalopathy.
In
this
study,
Mendelian
randomization
was
employed
to
analyze
changes
in
the
serum
metabolites
of
patients
with
encephalopathy,
and
metabolomics
analysis
conducted
detect
differential
a
rat
model
encephalopathy
induced
by
insulin
overdose.
The
results
indicated
an
overall
upward
trend
tryptophan
metabolism
pathway
rats
caused
overdose,
while
glutamate
levels
declined.
metabolic
provide
new
insights
into
impact
hypoglycemia
on
brain
function.
related
products
have
certain
diagnostic
value
for
forensic
identification
overdose-induced
death.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9522 - 9522
Опубликована: Сен. 1, 2024
Liver
failure
profoundly
affects
the
immune
system,
leading
to
dysregulation
of
innate
and
adaptive
response.
This
review
explores
intricate
relationship
between
liver
function
homeostasis.
The
role
as
a
central
hub
in
response
initiation
is
elucidated,
emphasizing
its
involvement
hepatic
inflammation
induction
subsequent
systemic
inflammation.
Cytokines,
chemokines,
growth
factors,
lipid
mediators
orchestrate
these
processes,
serving
both
prognostic
biomarkers
potential
therapeutic
targets
failure-associated
dysregulation,
which
might
result
from
acute-on-chronic
(ACLF)
cirrhosis.
Furthermore,
delves
into
mechanisms
underlying
immunosuppression
failure,
encompassing
alterations
cell
functions
such
neutrophils,
macrophages,
natural
killer
cells
(NK
cells),
well
perturbations
responses
mediated
by
B
T
cells.
Conclusion:
Understanding
immunological
consequences
crucial
for
developing
targeted
interventions
improving
patient
outcomes
disease
management.
Journal of Dairy Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
This
study
aimed
to
investigate
the
relationship
between
cheese
consumption
and
risk
of
joint
pain,
as
well
assess
mediating
role
biomarkers.
Utilizing
Mendelian
randomization
methods,
we
analyzed
data
from
UK
Biobank
FinnGen
evaluate
link
intake
examining
44
biomarkers
potential
mediators.
The
findings
revealed
a
significant
inverse
association
mediated
by
various
biomarkers,
including
neutrophil
count,
apolipoprotein
A,
peak
expiratory
flow,
cystatin
C,
IGF-1,
sex
hormone–binding
globulin,
urate,
automated
diastolic
blood
pressure.
These
results
suggest
that
may
reduce
pain
affecting
specific
providing
scientific
basis
for
dietary
interventions
decrease
incidence
pain.
However,
study's
limitations
include
ethnic
homogeneity
sample
population
incomplete
analysis
indicating
need
further
research
confirm
expand
upon
these
initial
findings.
Expert Review of Hematology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 16, 2025
The
relationship
between
erythropoiesis-stimulating
agents
(ESAs)
and
malignant
neoplasms
(MNs)
has
been
controversial
in
previous
studies.
Our
study
aimed
to
explore
the
correlation
ESAs
MNs.
Drug-target
Mendelian
randomization
(MR)
analyses
were
conducted
evaluate
causal
associations
of
for
12
classifications
Meanwhile,
a
pharmacovigilance
was
performed
by
extracting
adverse
events
(AEs)
FDA
Adverse
Event
Reporting
System
(FAERS)
database
validate
complement
our
findings.
MR
analysis
revealed
negative
association
with
MN
ovary
(p
=
0.047),
liposarcoma(p
0.001),
small
cell
lung
cancer(p
0.017),
colorectal
0.004),
brain
meningioma(p
positive
bladder
eye
adnexa
0.012),
heart,
mediastinum
pleura
0.032),
lip
0.041),
larynx
0.015)，non
cancer
0.009),
melanoma
0.001).
Positive
signals
found
hematological
system,
digestive
organs,
central
nervous
adnexa,
head
neck
cancer,
mucinous
cystic
tumor
FAERS
(all
reporting
odds
ratio
(ROR)
proportional
(PRR)
>1).
causally
correlated
many
types
More
attention
needs
be
paid
use
these
tumors.
ABSTRACT
Objectives
Diabetic
nephropathy
(DN)
is
a
severe
complication
of
diabetes
mellitus,
and
its
pathogenesis
remains
incompletely
understood.
Emerging
evidence
suggests
potential
link
between
gut
microbiota
DN.
This
study
aimed
to
explore
the
causal
relationship
DN
using
two‐sample
Mendelian
randomization
(MR)
approach.
Methods
Gut
data
were
obtained
from
MiBioGen
consortium,
which
provides
most
comprehensive
genome‐wide
association
studies
(GWAS)
on
microbiota.
Summary‐level
genetic
for
sourced
publicly
available
GWAS
provided
by
FinnGen
consortium.
The
primary
analysis
was
conducted
inverse
variance–weighted
(IVW)
method,
complemented
sensitivity
analyses
evaluate
pleiotropy
heterogeneity.
Results
Fourteen
species
demonstrated
significant
associations
with
in
MR
analysis,
including
five
negatively
nine
positively
associated
species,
as
determined
IVW
method.
No
or
heterogeneity
observed,
ensuring
robustness
findings.
Conclusions
novel
insight
into
role
pathogenesis,
uncovering
specific
microbial
that
may
contribute
disease
progression.
These
findings
offer
promising
avenue
future
research
therapeutic
development
targeting
