The Role of Autophagy in Type 2 Diabetic Kidney Disease Management

Cells, Год журнала: 2023, Номер 12(23), С. 2691 - 2691

Опубликована: Ноя. 23, 2023

Diabetic kidney disease (DKD), or diabetic nephropathy (DN), is one of the most prevalent complications type 2 diabetes mellitus (T2DM) and causes severe burden on general welfare T2DM patients around world. While several new agents have shown promise in treating this condition potentially halting progression disease, more work needed to understand complex regulatory network involved disorder. Recent studies provided insights into connection between autophagy, a physiological metabolic process known maintain cellular homeostasis, pathophysiological pathways DKD. Typically, autophagic activity plays role DKD mainly by promoting an inflammatory response tissue damage, while both overactivated downregulated autophagy worsen outcomes different stages This correlation demonstrates potential as novel therapeutic target for also highlights possibilities utilizing already available DN-related medications. In review, we summarize findings relationship DKD, impact these results clinical management strategies.

Язык: Английский

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Role of inflammation in the progression of diabetic kidney disease

Vessel Plus, Год журнала: 2024, Номер unknown

Опубликована: Июль 11, 2024

Diabetic kidney disease (DKD) is a global health burden and the leading cause of end-stage renal disease. Its clinical management focuses on controlling hyperglycemia, hypertension, hyperlipidemia. While progression DKD can be slowed with intervention, it cannot stopped or reversed yet. The pathogenesis complex, an interplay numerous signaling pathways, research continues to decipher players their role, beneficial pathogenic. Inflammation essential defense our bodies against internal external insults. injuries that trigger inflammation range from pathogenic infections wounds dysregulated metabolism. helpful only if controlled subsides after has helped defend individual insult. Uncontrolled chronic recognized as contributor diseases. Dysregulated plays role in multiple aspects DKD: glomerular hyperfiltration, mesangial expansion, podocyte injury, tubular basement membrane thickening, fibrosis, scarring. Since integral DKD, targeting for therapy also reasonable. There growing trend therapeutic approach, new targets being discovered evaluated drugs every year. exponential increase literature necessitates comprehensive summary current information, hence this review.

Язык: Английский

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Hederagenin Improves Adriamycin-induced Nephropathy by Inhibiting the JAK/STAT Signaling Pathway

Integrative Medicine in Nephrology and Andrology, Год журнала: 2024, Номер 11(2)

Опубликована: Апрель 23, 2024

ABSTRACT Background: Glomerulonephritis, a common kidney disease and major cause of end-stage renal disease, lacks effective treatment options. Hederagenin (HDG) exerts potent anti-inflammatory protective effects on the kidneys exhibits promise for glomerulonephritis. This study aimed to investigate therapeutic mechanism action hederagenin in context adriamycin-induced nephropathy (ADN). Methods: C57BL/6 mice were randomly divided into 5 groups that included control, model, low-dose HDG (20 mg/kg), high-dose (40 positive control (10 mg/kg irbesartan) groups. ADN was established by administering single injection 10 adriamycin. Renal pathology fibrosis assessed using haematoxylin eosin (H & E) Masson’s trichrome staining, whereas vitro studies conducted cultured mouse podocytes (MPC5). Immunofluorescence staining western blotting performed detect inflammation protein levels signaling pathways. Results: The results revealed significantly improved abnormal serum creatinine, albumin, urea nitrogen levels. reduced glomerular injury fibrosis, particularly at high doses. Additionally, effectively activation Janus kinase-signal transducer activator transcription (JAK/STAT) while suppressing CD4 + /CD8 cell ratios enhancing immune response. Interestingly, when JAK/STAT pathway activated an agonist, ameliorative inhibited, thus suggesting is key target HDG. Conclusion: may represent promising option glomerulonephritis inhibiting JAK/STAT-mediated immune-inflammatory responses.

Язык: Английский

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Role of Extracellular Vesicle-Derived Noncoding RNAs in Diabetic Kidney Disease

Kidney Diseases, Год журнала: 2024, Номер 10(4), С. 303 - 312

Опубликована: Янв. 1, 2024

Diabetic kidney disease (DKD), a metabolism-related syndrome characterized by abnormal glomerular filtration rate, proteinuria, and renal microangiopathy, is one of the most common forms chronic disease, whereas extracellular vesicles (EVs) have been recently evidenced as novel cell communication player in DKD occurrence progress via releasing various bioactive molecules, including proteins, lipids, especially RNA, among which noncoding RNAs (including miRNAs, lncRNAs, circRNAs) are major regulators. However, functional relevance EV-derived ncRNAs to be elucidated.

Язык: Английский

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Lycorine relieves the CCl4-induced liver fibrosis mainly via the JAK2/STAT3 and PI3K/AKT signaling pathways

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 489, С. 117017 - 117017

Опубликована: Июнь 24, 2024

Язык: Английский

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