Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(13), С. 6966 - 6966

Опубликована: Июнь 23, 2022

Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the gastrointestinal tract with highly heterogeneous presentation. It has relapsing and remitting clinical course that necessitates lifelong monitoring treatment. Although availability variety effective therapeutic options including immunomodulators biologics (such as TNF, CAM inhibitors) led to paradigm shift in treatment outcomes management IBD patients, some patients still either fail respond or lose their responsiveness therapy over time. Therefore, according recent Selecting Therapeutic Targets Bowel Disease (STRIDE-II) recommendations, continuous from symptomatic relief endoscopic healing along short- long-term responses are critical for providing tailored algorithm. Moreover, considering high unmet need novel approaches various new modulators cytokine signaling events (for example, JAK/TYK inhibitors), inhibitors cytokines example IL-12/IL-23, IL-22, IL-36, IL-6 anti-adhesion migration strategies β7 integrin, sphingosine 1-phosphate receptors, stem cells), well microbial-based therapeutics decolonize bed buds fecal microbiota transplantation bacterial currently being evaluated different phases controlled trials. This review aims offer comprehensive overview available emerging patients. Furthermore, predictive biomarkers response therapies also discussed.

Язык: Английский

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Predictive biomarkers for anti-TNF alpha therapy in IBD patients

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 16, 2024

Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition characterized by severe gut inflammation, commonly presenting as Crohn's disease, ulcerative colitis or categorized IBD- unclassified. While various treatments have demonstrated efficacy in adult IBD patients, the advent of anti-TNF therapies has significantly revolutionized treatment outcomes and clinical management. These played pivotal role achieving endoscopic remission, promoting mucosal healing, averting progression, diminishing necessity for surgery. Nevertheless, not all patients exhibit positive responses to these therapies, some may experience loss responsiveness over time. This review aims present comprehensive examination predictive biomarkers monitoring therapeutic response therapy patients. It will explore their limitations utilities, paving way more personalized effective approach.

Язык: Английский

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Effects of hepatitis B virus infection and strategies for preventing mother-to-child transmission on maternal and fetal T-cell immunity

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 16, 2023

One of the most common routes chronic hepatitis B virus (HBV) infection is mother-to-child transmission (MTCT). Approximately 6.4 million children under age five have HBV infections worldwide. DNA high level, HBeAg positivity, placental barrier failure, and immaturity fetal immune are possible causes infection. The passive-active program for children, which consists vaccine immunoglobulin, antiviral therapy pregnant women who a load (greater than 2 × 105 IU/ml), currently two important ways to prevent from mother child. Unfortunately, some infants still infections. Some studies also found that supplementation during pregnancy can increase cytokine levels then affect level HBsAb in infants. For example, IL-4 mediate beneficial effect on infants' when maternal folic acid supplementation. In addition, new research has indicated may be linked unfavorable outcomes such as gestational diabetes mellitus, intrahepatic cholestasis pregnancy, premature rupture membranes. changes environment hepatotropic nature main reasons adverse outcomes. It interesting note after delivery, had spontaneously achieve seroconversion HBsAg seroclearance. T-cell immunity because adaptive responses, especially virus-specific CD8 largely responsible viral clearance disease pathogenesis Meanwhile, humoral responses durability protection vaccination. This article reviews literature immunological characteristics HBV-infected patients postpartum, blocking transmissions related mechanisms, hoping provide insights prevention MTCT intervention postpartum.

Язык: Английский

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Global prevalence of antibiotic consumption during pregnancy: A systematic review and meta-analysis

Journal of Infection, Год журнала: 2024, Номер 89(2), С. 106189 - 106189

Опубликована: Июнь 5, 2024

Язык: Английский

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Trends in global and regional incidence and prevalence of hypertensive disordersin pregnancy (1990–2021): an age-period-cohort analysis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 9, 2025

Язык: Английский

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Vaginal Microbiome: Considerations For Reproductive Health

Future Microbiology, Год журнала: 2022, Номер 17(18), С. 1501 - 1513

Опубликована: Окт. 31, 2022

The microbial communities are an indispensable part of the human defense system and coexist with humans as symbionts, contributing to metabolic functions immune against pathogens. An ecologically stable vaginal microbiota is dominated by Lactobacillus species, which plays important role in prevention genital infections controlling pH, reducing glycogen lactic acid, stimulating bacteriocins hydrogen peroxide. In contrast, abnormal composition associated increased risk bacterial vaginosis, trichomoniasis, sexually transmitted diseases, preterm labor other birth defects. This diversity affected race, ethnicity, pregnancy, hormonal changes, sexual activities, hygiene practices conditions. present review, we discuss changes community region at different stages a female's life cycle its influence on her reproductive health pathological

Язык: Английский

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Maternal immune activation and its multifaceted effects on learning and memory in rodent offspring: A systematic review

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 164, С. 105844 - 105844

Опубликована: Авг. 4, 2024

This systematic review explored the impact of maternal immune activation (MIA) on learning and memory behavior in offspring, with a particular focus sexual dimorphism. We analyzed 20 experimental studies involving rodent models (rats mice) exposed to either lipopolysaccharide (LPS) or POLY I:C during gestation following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Our findings reveal that most report detrimental MIA performance highlighting significant role prenatal environmental factors neurodevelopment. Furthermore, this underscores complex effects sex, males often exhibiting more pronounced cognitive impairment compared females. Notably, small subset enhanced function MIA, suggesting complex, context-dependent outcomes challenges. also highlights sex differences caused by terms cytokine responses, alterations gene expression, microglial responses as contribute observed.

Язык: Английский

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Pregnancy and infection

Ugeskrift for Læger, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Авг. 5, 2024

Infections in pregnancy are common, and although often not harmful to the woman or her unborn child, some infections may be associated with severe adverse outcomes. Pregnancy causes physiological immunological adaptations which make pregnant women more susceptible at increased risk of illness. represent a challenging area concern for many specialists general practitioners. Center Infection was developed enhance knowledge, diagnosis, treatment, care infection Denmark, as pointed out this review.

Язык: Английский

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Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 31, 2024

Infectious diseases have consistently served as pivotal influences on numerous civilizations, inducing morbidity, mortality, and consequently redirecting the course of history. Their impact extends far beyond acute phase, characterized by majority symptom presentations, to a multitude adverse events sequelae that follow viral, parasitic, fungal, or bacterial infections. In this context, myriad related various infectious been identified, spanning short long-term durations. Although these are known affect thousands individuals individually, comprehensive evaluation all potential effects has yet be undertaken. We present literature review delineating primary attributable major diseases, categorized systems, symptoms, duration. This compilation serves crucial resource, illuminating ramifications for healthcare professionals worldwide. Moreover, highlights substantial burden impose global health economies, facet often overshadowed predominant focus phase. Patients frequently discharged following resolution with minimal follow-up comprehend address sequelae. emphasizes pressing need sustained vigilance, thorough patient monitoring, strategic management, rigorous research understand mitigate lasting economic impacts more fully.

Язык: Английский

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A cross-sectional analysis of preterm birth incidence and survival in Al Kharj, Saudi Arabia

Saudi Medical Journal, Год журнала: 2024, Номер 45(7), С. 710 - 718

Опубликована: Июль 1, 2024

To understand the prevalence and survival rates of preterm birth (PTB) is utmost importance in informing healthcare planning, improving neonatal care, enhancing maternal infant health, monitoring long-term outcomes, guiding policy advocacy efforts.

Язык: Английский

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