The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

Nature Metabolism, Год журнала: 2024, Номер 6(5), С. 947 - 962

Опубликована: Май 20, 2024

Язык: Английский

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From Gut to Hormones: Unraveling the Role of Gut Microbiota in (Phyto)Estrogen Modulation in Health and Disease

Molecular Nutrition & Food Research, Год журнала: 2024, Номер 68(6)

Опубликована: Фев. 11, 2024

Abstract The human gut microbiota regulates estrogen metabolism through the “estrobolome,” collection of bacterial genes that encode enzymes like β‐glucuronidases and β‐glucosidases. These deconjugate reactivate estrogen, influencing circulating levels. estrobolome mediates enterohepatic circulation bioavailability estrogen. Alterations in composition function have been associated with estrogen‐related diseases breast cancer, enometrial polycystic ovarian syndrome (PCOS). This is likely due to dysregulated signaling partly contributed by microbial impacts on metabolism. Dietary phytoestrogens also undergo into active metabolites equol, which binds receptors exhibits higher estrogenic potency than its precursor daidzein. However, ability produce equol varies across populations, depending presence specific microbes. Characterizing equol‐producing populations can provide microbiome‐based biomarkers. Further research needed investigate components estrobolome, phytoestrogen‐microbiota interactions, mechanisms linking dysbiosis pathology. current evidence suggests an integral regulator status clinical relevance women's health hormonal disorders.

Язык: Английский

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The Role of Lifestyle Interventions in PCOS Management: A Systematic Review

Nutrients, Год журнала: 2025, Номер 17(2), С. 310 - 310

Опубликована: Янв. 16, 2025

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders among reproductive-aged women. It characterized by hyperandrogenism, anovulation, and polycystic ovaries. Lifestyle changes are suggested as first-line interventions in managing PCOS. This systematic review aims to assess scientific evidence regarding role lifestyle modifications (dietary changes, physical activity, behavioral changes) improving reproductive, anthropometric, metabolic, psychological outcomes women with Dietary such foods low glycemic index scores; caloric restrictions; high-fiber, omega three fatty acid-rich diets; ketogenic Mediterranean antioxidant-rich food; anti-inflammatory diets improve insulin sensitivity hormonal balance Physical like aerobic resistance exercise, enhances sensitivity, helps weight loss, improves metabolic reproductive Further, education modules can also be used awareness, adherence, effectiveness conventional treatment manage mental health issues related Collectively, not only biochemical, hormonal, anthropometric parameters PCOS patients but reduce long-term risks cardiovascular diseases.

Язык: Английский

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A Critical Perspective on the Supplementation of Akkermansia muciniphila: Benefits and Harms

Life, Год журнала: 2023, Номер 13(6), С. 1247 - 1247

Опубликована: Май 24, 2023

Akkermansia muciniphila is a mucin-degrading bacterium of the intestinal niche, exerting beneficial effects on host metabolic profile. Accumulating evidence indicated as promising therapeutic probiotic against disorders such obesity, type 2 diabetes and cardiovascular diseases. However, in specific microenvironments, its excessive enrichment may be not beneficial. Conditions like inflammatory bowel disease (IBD), Salmonella typhimurium infection or post-antibiotic reconstitution benefit from supplementation. Furthermore, using patients with endocrine gynecological disorders-such polycystic ovary syndrome (PCOS) endometriosis-that have higher risk developing IBD, should critically evaluated. In addition, cautionary note comes neurological field, gut microbiota suffering Parkinson's multiple sclerosis exhibits characteristic signature municiphila abundance. Overall, considering these controversial points, use evaluated an individual basis, avoiding risking unexpected effects.

Язык: Английский

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A disturbed communication between hypothalamic-pituitary-ovary axis and gut microbiota in female infertility: is diet to blame?

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 21, 2025

Female infertility is a multifactorial condition influenced by various genetic, environmental, and lifestyle factors. Recent research has investigated the significant impact of gut microbiome dysbiosis on systemic inflammation, metabolic dysfunction, hormonal imbalances, which can potentially impair fertility. The gut-brain axis, bidirectional communication system between brain, also plays role in regulating reproductive functions. Emerging evidence suggests that influence brain functions behavior, further emphasizing importance microbiota-gut-brain axis reproduction. Given their as major modulator microbiome, diet dietary factors, including patterns nutrient intake, have been implicated development management female infertility. Hence, this review aims to highlight patterns, such Western (WD) Mediterranean (MD), decipher modulatory action infertile women. By contrasting detrimental effects WD with therapeutic potential MD, we emphasize pivotal balanced rich nutrients promoting healthy microbiome. These insights underscore targeted interventions modifications promising strategies enhance outcomes subfertile

Язык: Английский

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Pathophysiological Effects of Contemporary Lifestyle on Evolutionary-Conserved Survival Mechanisms in Polycystic Ovary Syndrome

Life, Год журнала: 2023, Номер 13(4), С. 1056 - 1056

Опубликована: Апрель 20, 2023

Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary mismatch disorder that presents with a complex mixture of metabolic and endocrine symptoms. The Evolutionary Model proposes PCOS arises from collection inherited polymorphisms have been consistently demonstrated in variety ethnic groups races. In utero developmental programming susceptible genomic variants are thought to predispose the offspring develop PCOS. Postnatal exposure lifestyle environmental risk factors results epigenetic activation developmentally programmed genes disturbance hallmarks health. resulting pathophysiological changes represent consequences poor-quality diet, sedentary behaviour, disrupting chemicals, stress, circadian disruption, other factors. Emerging evidence suggests lifestyle-induced gastrointestinal dysbiosis plays central role pathogenesis Lifestyle exposures initiate result microbiome (dysbiosis), immune dysregulation (chronic inflammation), altered metabolism (insulin resistance), reproductive imbalance (hyperandrogenism), nervous system dysfunction (neuroendocrine autonomic system). can be progressive condition leads obesity, gestational diabetes, type two metabolic-associated fatty liver disease, syndrome, cardiovascular cancer. This review explores mechanisms underpin between ancient survival pathways contemporary involved pathophysiology

Язык: Английский

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Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(8)

Опубликована: Март 28, 2024

Abstract Polycystic ovary syndrome (PCOS) is one of the modern intractable reproductive diseases. The female irregular menstruation, infertility, obesity, and so forth caused by PCOS have become a hot issue affecting family harmony social development. aetiology complex. In recent years, many scholars found that its pathogenesis was related to imbalance gut microbiota. Gut microbiota can form two‐way communication with brain through ‘gut‐brain axis’ affect host's metabolism. Current research has confirmed interfere glucose lipid metabolism, insulin sensitivity, hormone secretion follicular development in women altering intestinal mucosal permeability secreting metabolites. addition, diversity composition patients changed, which may metabolic function ability produce metabolites, also directly or indirectly endocrine function. This study reviewed advances about role PCOS. order provide basis for prevention treatment based on

Язык: Английский

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The interplay of oxidative stress and immune dysfunction in Hashimoto’s thyroiditis and polycystic ovary syndrome: a comprehensive review

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июль 31, 2023

In recent years, there has been a significant increase in the concomitant incidence of Hashimoto’s thyroiditis (HT) and polycystic ovary syndrome (PCOS), both terms incidence, etiology, clinical consequences. PCOS patients suffering from autoimmune thyroid diseases show insulin resistance, impaired glucose tolerance, weight gain, metabolic reproductive complications. Studies have shown that chronic stress its consequence, i.e. oxidative stress, play an important role pathomechanism disorders. It also long-term exposure to triggers biological mechanisms, particular related regulation inflammatory cascade, which plays key diseases. The paper is review literature on immune processes pathogenesis HT PCOS. addition, source knowledge about treatment these diseases, use antioxidants therapeutic management.

Язык: Английский

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Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort

CJC Open, Год журнала: 2023, Номер 6(2), С. 314 - 326

Опубликована: Дек. 16, 2023

Polycystic ovary syndrome (PCOS) is the most common metabolic-endocrine disorder impacting health and quality of life women over lifespan. Evidence-based data on scope adverse outcomes in those affected by PCOS critical to improve healthcare this population. The aim study was determine prevalence with compared age-matched controls.

Язык: Английский

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A Molecular Perspective and Role of NAD+ in Ovarian Aging

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4680 - 4680

Опубликована: Апрель 25, 2024

The decline in female fecundity is linked to advancing chronological age. ovarian reserve diminishes quantity and quality as women age, impacting reproductive efficiency the aging process rest of body. NAD+ an essential coenzyme cellular energy production, metabolism, cell signaling, survival. It involved various age-related conditions. Hallmarks associated with aging, diseases, metabolic dysfunctions can significantly affect fertility by disturbing delicate relationship between metabolism reproduction. Enzymes such sirtuins, PARPs, CD38 play roles biology, which actively consume their enzymatic activities. In recent years, has gained much attention for its role diseases like cancer, Alzheimer’s, cardiovascular neurodegenerative disorders, highlighting involvement pathophysiological processes. However, impact on reproduction not well understood. This review aims bridge this knowledge gap comprehensively exploring complex interplay biology providing valuable information that could help develop plans improve women’s health prevent issues.

Язык: Английский

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