Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(14), С. 4243 - 4243

Опубликована: Июль 20, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) are prevalent conditions that have been correlated with infertility through overlapped pathophysiological mechanisms. MASLD is associated metabolic considered among the major causes of chronic disease, while PCOS, which characterized by ovulatory dysfunction hyperandrogenism, one leading female infertility. The links between PCOS not yet fully elucidated, insulin resistance, hyperandrogenemia, obesity, dyslipidemia being key pathways contribute to lipid accumulation, inflammation, fibrosis, aggravating dysfunction. On other hand, exacerbates resistance dysregulation in women creating a vicious cycle progression. Understanding intricate relationship crucial improving clinical management, collaborative efforts different medical specialties essential optimize fertility health outcomes individuals PCOS. In this review, we summarize complex interplay highlighting importance increasing attention prevention, diagnosis, treatment both entities.

Язык: Английский

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The Role of Diet, Glycaemic Index and Glucose Control in Polycystic Ovary Syndrome (PCOS) Management and Mechanisms of Progression

Current Nutrition Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Янв. 3, 2025

Abstract Purpose of Review Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder with several causal pathways including impaired glucose tolerance, insulin resistance (IR), compensatory hyperinsulinemia and excess androgens (hyperandrogenism). This heterogeneous condition causes range reproductive, metabolic psychological implications, the severity which can differ between individuals depending on factors such as age, diet, ethnicity, genetics, medication, contraceptive use, adiposity, Body Mass Index (BMI). Recent Findings Dietary interventions that focus low glycaemic index control are an efficient first-line dietary solution for management tolerance IR, subsequently improves weight management, quality life PCOS-related symptoms in this condition. Summary review aims to explore relevance nutrition more specifically, association load PCOS, well assess potential benefits manipulating those indexes approach syndrome.

Язык: Английский

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Exploring the Potential Use of Probiotics, Prebiotics, Synbiotics, and Postbiotics as Adjuvants for Modulating the Vaginal Microbiome: a Bibliometric Review

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Язык: Английский

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Polycystic Ovarian Syndrome: A Review of Multi-omics Analyses

Reproductive Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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Comparison of the impact of intermittent fasting diet alone or in conjunction with probiotic supplementation versus calorie-restricted diet on inflammatory, oxidative stress, and antioxidant capacity biomarkers in women with polycystic ovary syndrome: A randomized placebo-controlled trial

Journal of Research in Medical Sciences, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 1, 2025

Background: The objective of this study was to compare the effects early time-restricted eating (eTRE) and eTRE plus probiotic supplementation daily caloric restriction (DCR) alone in terms biomarkers oxidative stress (OS), antioxidant capacity, inflammation, blood pressure (BP) obese women with polycystic ovary syndrome (PCOS). Materials Methods: research conducted as a randomized, parallel, placebo-controlled clinical trial an 8-week follow-up period. Participants were randomly assigned one three groups: 14:10 ( n = 30), placebo or DCR 30). At beginning 8 weeks intervention, systolic (SBP) diastolic BP, OS parameters evaluated. Results: A total 90 participants (mean age, 30.49 years mean weight, 81.45 kg) enrolled trial. After we observed SBP significantly decreased both + group (−0.31 mmHg [95% confidence interval (CI): −0.55, −0.07]) (−0.24 CI: −0.43, 0.04]), no significant differences between groups. Moreover, C-reactive protein (CRP) levels reduced all groups P < 0.005). Total capacity (TAC) also showed notable improvement 0.012) 0.032). However, there regarding OS, TAC, CRP markers. Conclusion: It not found that probiotics intervention resulted improving inflammatory, than standard diet among PCOS. present did reveal improvements inflammatory markers, either combined compared diagnosed Trial Register no: IRCT20121110011421N5.

Язык: Английский

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Associations of Dietary Index for Gut Microbiota and Flavonoid Intake With Female Infertility in the United States

Food Science & Nutrition, Год журнала: 2025, Номер 13(4)

Опубликована: Март 26, 2025

This study aimed to investigate the associations between a dietary index for gut microbiota (DI-GM), flavonoid intake, and female infertility, while exploring age-specific differences in these relationships identify potential strategies infertility prevention. cross-sectional focused on participants aged 18-45 years, with data obtained from 2017-2018 cycle of National Health Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models were employed examine DI-GM, self-reported infertility. Age-stratified analyses performed evaluate whether varied across reproductive life stages. Higher DI-GM scores significantly associated reduced risk (aOR = 0.30, 95% CI: 0.13-0.71, p 0.006), strongest protective effects observed women < 35 years (Q3: aOR 0.13, 0.03-0.58, 0.007; Q4: 0.27, 0.09-0.77, 0.015). Beneficial also showed effect 0.75, 0.57-0.98, 0.036). Among ≥ moderate intake (Q2) significant inverse association 0.19, 0.06-0.66, 0.009). Our findings reveal novel evidence that higher are linked lower patterns observed. younger (< years), was years. These underscore personalized targeting composition as cost-effective approaches prevention management different

Язык: Английский

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Gut Microbiota: A New Challenge in Mood Disorder Research

Life, Год журнала: 2025, Номер 15(4), С. 593 - 593

Опубликована: Апрель 3, 2025

The gut microbiome has emerged as a novel and intriguing focus in mood disorder research. Emerging evidence demonstrates the significant role of influencing mental health, suggesting bidirectional communication between brain. This review examines latest findings on gut–microbiota–brain axis elucidates how alterations microbiota composition can influence this axis, leading to changes brain function behavior. Although dietary interventions, prebiotics, probiotics, fecal transplantation have yielded encouraging results, advances are needed establish next-generation approaches that precisely target neurobiological mechanisms disorders. Future research must developing personalized treatments, facilitated by innovative therapies technological progress, which account for individual variables such age, sex, drug history, lifestyle. Highlighting potential therapeutic implications targeting microbiota, emphasizes importance integrating into psychiatric studies develop more effective treatment strategies

Язык: Английский

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PCOS and genetics: Exploring the heterogeneous role of potential genes in ovarian dysfunction, a hallmark of PCOS – A review

Reproductive Biology, Год журнала: 2025, Номер 25(2), С. 101017 - 101017

Опубликована: Апрель 12, 2025

Язык: Английский

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The Gut-Wrenching Truth: Pathophysiology and Clinical Features of Intestinal Hyperpermeability Syndrome

European Journal of Medical and Health Research, Год журнала: 2025, Номер 3(2), С. 147 - 154

Опубликована: Март 27, 2025

The microbes associated with the gut are called microbiota. There about 1000 species of bacteria weighing up to 1-2 kg in human gut. Microbial diversity increases age until it is stable. Humans have evolved live them and learned play their role body. Dysbiosis microbiota causes various ailments, disorders diseases humans. And all this due increased intestinal permeability caused by dysbiosis. present review discusses some pathophysiological clinical symptoms leaky syndrome, a highly controversial but logical relevant topic medical microbiology gastroenterology

Язык: Английский

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Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients

Molecular Neurobiology, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 23, 2023

Язык: Английский

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