Association between increased and decreased gut microbiota abundance and Parkinson's disease: A systematic review and subgroup meta-analysis
Fusheng Bai,
Lin You,
Hongyan Lei
и другие.
Experimental Gerontology,
Год журнала:
2024,
Номер
191, С. 112444 - 112444
Опубликована: Апрель 29, 2024
The
objective
of
the
study
was
to
systematically
investigate
association
between
gut
microbiota
(GM)
abundance
and
Parkinson's
disease
(PD).
Язык: Английский
Curli protein: A potential contributor to α-synucleopathy in Parkinson's disease
Translational Medicine of Aging,
Год журнала:
2025,
Номер
9, С. 41 - 48
Опубликована: Янв. 1, 2025
Язык: Английский
Advances in autonomic dysfunction research in Parkinson’s disease
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Март 12, 2025
Parkinson’s
disease
(PD)
is
a
prevalent
neurodegenerative
disorder,
best
known
for
its
motor
symptoms
such
as
resting
tremor,
muscle
rigidity,
and
bradykinesia.
However,
autonomic
dysfunction
an
important
non-motor
aspect
that
often
brings
considerable
discomfort
distress
to
both
patients
their
families.
In
this
review,
we
summarize
recent
advances
in
understanding
the
pathophysiological
mechanisms
of
explore
relationship
with
other
clinical
features.
Our
aim
discover
novel
potential
diagnostic
therapeutic
strategies,
alleviate
patient
suffering,
pave
way
future
basic
research.
Язык: Английский
Gastrointestinal Manifestations in Parkinson's Disease Using a Validated Arabic Version of Gastrointestinal Dysfunction Scale: A Multicenter Study
Movement Disorders Clinical Practice,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 15, 2025
Abstract
Background
Gastrointestinal
symptoms
(GIS)
contribute
to
the
morbidity
of
Parkinson's
disease
(PD),
with
limited
specific
assessment
tools.
Objective
This
multicenter
study
aimed
translate
and
validate
Dysfunction
Scale
for
PD
(GIDS‐PD)
into
an
Arabic
version
investigate
characteristics
GIS
its
correlates.
Methods
A
total
162
patients
165
age‐
sex‐matched
healthy
controls
were
assessed
using
GIDS‐PD.
was
test–retest
reliability,
construct
validity,
convert
floor
or
ceiling
effects.
Patients
also
International
Parkinson
Movement
Disorders
Society‐Unified
Disease
Rating
Scale,
Non‐motor
Symptoms
Questionnaire‐39.
Results
The
GIDS‐PD
exhibited
proper
convergent
inter‐
intrarater
consistency,
acceptable
effect.
Compared
controls,
significantly
higher
frequency
all
items:
difficulty
in
passing
stools
(86.42%),
experiencing
hard
(65%),
sensation
incomplete
evacuation
(75.93%),
abdominal
pain
(69.14%),
abnormal
increase
(50.62%),
distention
(85.19%),
involuntary
weight
loss
(48.77%),
swallowing
(64.81%),
excessive
salivation
(68.52%),
heartburn
(82.10%),
nausea
(43.83%).
GISs
correlated
duration,
motor
nonmotor
severity,
complications,
poorer
quality
life
(QoL).
Predictors
included
stage,
burden,
age,
dopaminergic
daily
dosage.
Conclusion
provided
a
validated
demonstrated
high
different
GISs;
their
correlation
dosage,
age;
negative
impact
on
QoL,
implying
importance
management.
Язык: Английский
Cysteamine HCl Administration Impedes Motor and Olfactory Functions Accompanied by Reduced Dopaminergic Neurons in Experimental Mice: A Preclinical Mimetics Relevance to Parkinson’s Disease
Divya Bharathi Selvaraj,
Anusiya Panneerselvam,
Jemi Feiona Vergil Andrews
и другие.
Опубликована: Июнь 10, 2024
Cysteamine
HCl
has
been
established
as
a
potent
ulcerogenic
agent
of
the
gastrointestinal
(GI)
system.
GI
dysfunction
and
olfactory
deficits
are
most
common
clinical
symptoms
many
movement
disorders
including
Parkinson's
disease
(PD).
shown
to
interfere
with
dopamine,
neurotransmitter
crucial
for
motor,
olfactory,
cognitive
functions.
However,
reports
on
effect
cysteamine
treatment
behavior
dopamine
system
appear
be
inconsistent.
Therefore,
we
revisited
impact
motor
function
in
experimental
mice
using
battery
behavioral
tests
such
pole
test
(PT),
beam
walking
(BWT),
rotarod
(RDT),
while
ability
functions
were
examined
through
food
buried
(FBT)
Y
maze.
Furthermore,
investigated
density
dopaminergic
tyrosine
hydroxylase
(TH)-positive
cells
substantia
nigra
(SN)
bulb
(OB)
immunohistochemistry.
Results
revealed
that
administration
induced
significant
impairments
balance
coordination,
their
movement-related
performance
was
markedly
reduced
tasks.
Mice
exposed
showed
pronounced
reduction
odor
discrimination
impairments.
Strikingly,
number
TH-positive
neurons
found
SN
OB
HCl-treated
group
which
is
bonafide
neuropathogenic
hallmark
PD.
This
study
highlights
potential
neurotoxic
effects
brains
suggests
further
investigation
into
its
role
pathogenesis
Parkinsonism.
Язык: Английский
Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson’s Disease
Divya Bharathi Selvaraj,
Anusiya Panneerselvam,
Jemi Feiona Vergil Andrews
и другие.
Brain Sciences,
Год журнала:
2024,
Номер
14(7), С. 632 - 632
Опубликована: Июнь 24, 2024
Cysteamine
hydrochloride
(Cys-HCl)
has
been
established
as
a
potent
ulcerogenic
agent
of
the
gastrointestinal
(GI)
system.
GI
dysfunction
and
olfactory
deficits
are
most
common
clinical
symptoms
many
movement
disorders,
including
Parkinson's
disease
(PD).
Cys-HCl
shown
to
interfere
with
dopamine,
neurotransmitter
crucial
for
motor,
olfactory,
cognitive
functions.
However,
reports
on
effect
treatment
behavioral
aspects
functions
dopamine
system
appear
be
inconsistent.
Therefore,
we
revisited
impact
motor
function
in
experimental
mice
using
battery
tests,
such
pole
test
(PT),
beam-walking
(BWT),
rotarod
(RDT),
while
ability
were
examined
through
buried-food
(BFT)
Y-maze
test.
Furthermore,
investigated
number
dopaminergic
tyrosine
hydroxylase
(TH)-positive
cells
substantia
nigra
(SN)
bulb
(OB)
immunohistochemistry.
The
results
revealed
that
administration
induced
significant
impairments
their
balance
coordination,
movement-related
performances
markedly
reduced
terms
tasks.
Mice
exposed
showed
pronounced
reductions
odor
discrimination
abilities
well
impairments.
Strikingly,
TH-positive
neurons
was
found
SN
OB
Cys-HCl-treated
group,
which
is
bonafide
neuropathogenic
hallmark
PD.
This
study
highlights
potential
neurotoxic
effects
brains
suggests
further
investigation
into
its
role
pathogenesis
Parkinsonism.
Язык: Английский