Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson’s Disease DOI Creative Commons

Divya Bharathi Selvaraj,

Anusiya Panneerselvam,

Jemi Feiona Vergil Andrews

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 632 - 632

Published: June 24, 2024

Cysteamine hydrochloride (Cys-HCl) has been established as a potent ulcerogenic agent of the gastrointestinal (GI) system. GI dysfunction and olfactory deficits are most common clinical symptoms many movement disorders, including Parkinson's disease (PD). Cys-HCl shown to interfere with dopamine, neurotransmitter crucial for motor, olfactory, cognitive functions. However, reports on effect treatment behavioral aspects functions dopamine system appear be inconsistent. Therefore, we revisited impact motor function in experimental mice using battery tests, such pole test (PT), beam-walking (BWT), rotarod (RDT), while ability were examined through buried-food (BFT) Y-maze test. Furthermore, investigated number dopaminergic tyrosine hydroxylase (TH)-positive cells substantia nigra (SN) bulb (OB) immunohistochemistry. The results revealed that administration induced significant impairments their balance coordination, movement-related performances markedly reduced terms tasks. Mice exposed showed pronounced reductions odor discrimination abilities well impairments. Strikingly, TH-positive neurons was found SN OB Cys-HCl-treated group, which is bonafide neuropathogenic hallmark PD. This study highlights potential neurotoxic effects brains suggests further investigation into its role pathogenesis Parkinsonism.

Language: Английский

Association between increased and decreased gut microbiota abundance and Parkinson's disease: A systematic review and subgroup meta-analysis DOI Creative Commons

Fusheng Bai,

Lin You,

Hongyan Lei

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 191, P. 112444 - 112444

Published: April 29, 2024

The objective of the study was to systematically investigate association between gut microbiota (GM) abundance and Parkinson's disease (PD).

Language: Английский

Citations

8
Curli protein: A potential contributor to α-synucleopathy in Parkinson's disease DOI Creative Commons

Nabanita Ghosh,

Krishnendu Sinha

Translational Medicine of Aging, Journal Year: 2025, Volume and Issue: 9, P. 41 - 48

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in autonomic dysfunction research in Parkinson’s disease DOI Creative Commons
Huichun Xu,

Xiaolei Zheng,

Xinyue Xing

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 12, 2025

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, best known for its motor symptoms such as resting tremor, muscle rigidity, and bradykinesia. However, autonomic dysfunction an important non-motor aspect that often brings considerable discomfort distress to both patients their families. In this review, we summarize recent advances in understanding the pathophysiological mechanisms of explore relationship with other clinical features. Our aim discover novel potential diagnostic therapeutic strategies, alleviate patient suffering, pave way future basic research.

Language: Английский

Citations

0
Gastrointestinal Manifestations in Parkinson's Disease Using a Validated Arabic Version of Gastrointestinal Dysfunction Scale: A Multicenter Study DOI Open Access
Ali Shalash, Marwa Y. Badr,

Yara Salah

et al.

Movement Disorders Clinical Practice, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract Background Gastrointestinal symptoms (GIS) contribute to the morbidity of Parkinson's disease (PD), with limited specific assessment tools. Objective This multicenter study aimed translate and validate Dysfunction Scale for PD (GIDS‐PD) into an Arabic version investigate characteristics GIS its correlates. Methods A total 162 patients 165 age‐ sex‐matched healthy controls were assessed using GIDS‐PD. was test–retest reliability, construct validity, convert floor or ceiling effects. Patients also International Parkinson Movement Disorders Society‐Unified Disease Rating Scale, Non‐motor Symptoms Questionnaire‐39. Results The GIDS‐PD exhibited proper convergent inter‐ intrarater consistency, acceptable effect. Compared controls, significantly higher frequency all items: difficulty in passing stools (86.42%), experiencing hard (65%), sensation incomplete evacuation (75.93%), abdominal pain (69.14%), abnormal increase (50.62%), distention (85.19%), involuntary weight loss (48.77%), swallowing (64.81%), excessive salivation (68.52%), heartburn (82.10%), nausea (43.83%). GISs correlated duration, motor nonmotor severity, complications, poorer quality life (QoL). Predictors included stage, burden, age, dopaminergic daily dosage. Conclusion provided a validated demonstrated high different GISs; their correlation dosage, age; negative impact on QoL, implying importance management.

Language: Английский

Citations

0
Cysteamine HCl Administration Impedes Motor and Olfactory Functions Accompanied by Reduced Dopaminergic Neurons in Experimental Mice: A Preclinical Mimetics Relevance to Parkinson’s Disease DOI Open Access

Divya Bharathi Selvaraj,

Anusiya Panneerselvam,

Jemi Feiona Vergil Andrews

et al.

Published: June 10, 2024

Cysteamine HCl has been established as a potent ulcerogenic agent of the gastrointestinal (GI) system. GI dysfunction and olfactory deficits are most common clinical symptoms many movement disorders including Parkinson's disease (PD). shown to interfere with dopamine, neurotransmitter crucial for motor, olfactory, cognitive functions. However, reports on effect cysteamine treatment behavior dopamine system appear be inconsistent. Therefore, we revisited impact motor function in experimental mice using battery behavioral tests such pole test (PT), beam walking (BWT), rotarod (RDT), while ability functions were examined through food buried (FBT) Y maze. Furthermore, investigated density dopaminergic tyrosine hydroxylase (TH)-positive cells substantia nigra (SN) bulb (OB) immunohistochemistry. Results revealed that administration induced significant impairments balance coordination, their movement-related performance was markedly reduced tasks. Mice exposed showed pronounced reduction odor discrimination impairments. Strikingly, number TH-positive neurons found SN OB HCl-treated group which is bonafide neuropathogenic hallmark PD. This study highlights potential neurotoxic effects brains suggests further investigation into its role pathogenesis Parkinsonism.

Language: Английский

Citations

1
Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson’s Disease DOI Creative Commons

Divya Bharathi Selvaraj,

Anusiya Panneerselvam,

Jemi Feiona Vergil Andrews

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 632 - 632

Published: June 24, 2024

Cysteamine hydrochloride (Cys-HCl) has been established as a potent ulcerogenic agent of the gastrointestinal (GI) system. GI dysfunction and olfactory deficits are most common clinical symptoms many movement disorders, including Parkinson's disease (PD). Cys-HCl shown to interfere with dopamine, neurotransmitter crucial for motor, olfactory, cognitive functions. However, reports on effect treatment behavioral aspects functions dopamine system appear be inconsistent. Therefore, we revisited impact motor function in experimental mice using battery tests, such pole test (PT), beam-walking (BWT), rotarod (RDT), while ability were examined through buried-food (BFT) Y-maze test. Furthermore, investigated number dopaminergic tyrosine hydroxylase (TH)-positive cells substantia nigra (SN) bulb (OB) immunohistochemistry. The results revealed that administration induced significant impairments their balance coordination, movement-related performances markedly reduced terms tasks. Mice exposed showed pronounced reductions odor discrimination abilities well impairments. Strikingly, TH-positive neurons was found SN OB Cys-HCl-treated group, which is bonafide neuropathogenic hallmark PD. This study highlights potential neurotoxic effects brains suggests further investigation into its role pathogenesis Parkinsonism.

Language: Английский

Citations

1