Stress and the gut-brain axis: an inflammatory perspective

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Июль 18, 2024

The gut-brain axis (GBA) plays a dominant role in maintaining homeostasis as well contributes to mental health maintenance. pathways that underpin the expand from macroscopic interactions with nervous system, molecular signals include microbial metabolites, tight junction protein expression, or cytokines released during inflammation. dysfunctional GBA has been repeatedly linked occurrence of anxiety- and depressive-like behaviors development. importance inflammatory aspects altered recently highlighted literature. Here we summarize current reports on signaling which involves immune response within intestinal blood-brain barrier (BBB). We also emphasize effect stress altering barriers' permeability, therapeutic potential microbiota restoration by probiotic administration transplantation, based latest animal studies. Most research performed various models showed an association between behaviors, dysbiosis gut microbiota, disruption permeability simultaneous changes BBB integrity. It could be postulated under conditions impaired communication across may therefore represent significant mechanism allowing affect brain functions.

Язык: Английский

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Synergistic effects of plant polysaccharides and exercise on depression alleviation from the microbiota-gut-brain axis

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105967 - 105967

Опубликована: Янв. 1, 2025

Язык: Английский

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Gut microbiota: A bridge between depression and cardiovascular disease-A narrative review

The Microbe, Год журнала: 2025, Номер unknown, С. 100292 - 100292

Опубликована: Март 1, 2025

Язык: Английский

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Gut microbiota in health and disease: advances and future prospects

MedComm, Год журнала: 2024, Номер 5(12)

Опубликована: Ноя. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Язык: Английский

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Current landscape of fecal microbiota transplantation in treating depression

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 25, 2024

Depression, projected to be the predominant contributor global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication psychotherapy often fall short, prompting pursuit of alternative interventions. Recent research has highlighted significant role gut microbiota in mental health, influencing emotional neural regulation. Fecal transplantation (FMT), infusion fecal matter from healthy donor into patient, emerges promising strategy ameliorate depressive by restoring microbial balance. The microbial-gut-brain (MGB) axis represents critical pathway through which potentially rectify dysbiosis modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals reduce inflammatory markers, thereby alleviating behaviors. Moreover, shown promise clinical settings, improving gastrointestinal overall quality life patients depression. review highlights gut-brain depression need for further validate long-term safety efficacy FMT, identify specific therapeutic strains, develop targeted modulation strategies. Advancing our understanding could revolutionize treatment, shifting paradigm toward microbiome-targeting therapies.

Язык: Английский

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Mental Health Disorders Due to Gut Microbiome Alteration and NLRP3 Inflammasome Activation After Spinal Cord Injury: Molecular Mechanisms, Promising Treatments, and Aids from Artificial Intelligence

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 197 - 197

Опубликована: Фев. 14, 2025

Aside from its immediate traumatic effects, spinal cord injury (SCI) presents multiple secondary complications that can be harmful to those who have been affected by SCI. Among these gut dysbiosis (GD) and the activation of NOD (nucleotide-binding oligomerization domain) like receptor-family pyrin-domain-containing three (NLRP3) inflammasome are special interest for their roles in impacting mental health. Studies found state microbiome is thrown into disarray after SCI, providing a chance GD occur. Metabolites such as short-chain fatty acids (SCFAs) variety neurotransmitters produced hampered GD. This disrupts healthy cognitive processes opens door SCI patients impacted health disorders. Additionally, some studies an increased presence NLRP3 respective parts patients. Preclinical clinical shown plays key role maturation pro-inflammatory cytokines initiate eventually aggravate disorders In addition mechanisms intensifying this review article further focuses on promising treatments: fecal transplants, phytochemicals, melatonin. treatments effective combating pathogenic inflammasome, well alleviating symptoms may Another area focus exploring how artificial intelligence (AI) used support treatments. AI models already developed track changes microbiome, simulate drug-gut interactions, design novel anti-NLRP3 peptides. While promising, research applications treatment needed.

Язык: Английский

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Gut-Microbiota-Derived Butyric Acid Overload Contributes to Ileal Mucosal Barrier Damage in Late Phase of Chronic Unpredictable Mild Stress Mice

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12998 - 12998

Опубликована: Дек. 3, 2024

Intestinal mucosal barrier damage is regarded as the critical factor through which chronic unpredictable mild stress (CUMS) leads to a variety of physical and mental health problems. However, exact mechanism by CUMS induces intestinal unclear. In this study, 14, 28, 42 d model mice were established. The indicators related ileal (IMBD), composition microbiota its amino acid (AA) short-chain fatty (SCFA) metabolic functions, free (FAA) SCFA levels in lumen measured before after each period. correlations between them are analyzed investigate how male C57BL/6 mice. With progression CUMS, butyric (BA) decreased (14 28 d) then increased (42 d), IMBD progressively increased. late stage degree most severe positively correlated with significantly BA (

Язык: Английский

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Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

CNS Neuroscience & Therapeutics, Год журнала: 2023, Номер 30(4)

Опубликована: Окт. 31, 2023

Abstract Background The microbiota–gut–brain axis plays a critical role in neuropsychiatric disorders, particularly anxious depression, and attracts more attention gradually. Zhi Zi Chi decoction (ZZCD) consisting of Gardenia jasminoides J. Ellis Glycine max (L.) Merr , is classic formula clinic widely applied anxiety depression treatment. However, the underlying mechanisms regulating treatment by oral administration ZZCD remain elusive. Materials Methods In this project, we clarified origin preparation methods examined chemical ingredients liquid chromatograph mass spectrometer. Then, corticosterone combined with chronic restraint stress was to establish an model. After treated standard decoction, based on enzyme‐linked immunosorbent assay (ELISA), 16S rRNA technology, high‐throughput sequencing, quantitative RT‐PCR fecal microbiota transplantation (FMT), multiple associations between nucleus accumbens intestinal flora mice were determined clarify mechanism disorder. Results We found various substances antidepressant antianxiety properties such as rosiridin oleanolic acid. could alleviate depressive behaviors via disturbance gut microbiota. Meanwhile, bioactive compounds might directly active neurodevelopment neuroimmune‐related genes. Furthermore, secretion prolactin estrogen, interfering mitogen‐activated protein kinase (MAPK) tumor necrosis factor (TNF) signaling pathways mainly involved multi‐target therapeutic effects against depression. Conclusions These findings suggested that exerts pleiotropically through modulating microbiota‐gut‐brain.

Язык: Английский

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Tong-Xie-Yao-Fang strengthens intestinal feedback control of bile acid synthesis to ameliorate irritable bowel syndrome by enhancing bile salt hydrolase-expressing microbiota

Journal of Ethnopharmacology, Год журнала: 2024, Номер 331, С. 118256 - 118256

Опубликована: Апрель 25, 2024

Язык: Английский

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The antidepressant effect of Shexiang Baoxin Pills on myocardial infarction rats with depression may be achieved through the inhibition of the NLRP3 inflammasome pathway

Brain and Behavior, Год журнала: 2024, Номер 14(7)

Опубликована: Июль 1, 2024

Abstract Background Patients with myocardial infarction (MI) frequently experience a heightened incidence of depression, thereby increasing the risk adverse cardiovascular events. Consequently, early detection and intervention in depressive symptoms among patients MI are imperative. Shexiang Baoxin Pills (SBP), Chinese patent medicine employed for treatment MI, exhibits diverse mechanisms targeting this condition. Nevertheless, its therapeutic efficacy on postmyocardial remains unclear. The aim study is to investigate effectiveness mechanism SBP managing depression during acute (AMI). Methods A rat model combining was established, rats were randomly divided into four groups: (MOD) group, Fluoxetine (FLX) Sham group. After 28 days drug intervention, cardiac function assessed using echocardiography while behavior evaluated through sucrose preference test (SPT), forced swimming (FST), open‐field (OFT). Additionally, levels inflammatory factors serum hippocampus measured along NLRP3 inflammasome‐related protein expression via Western blotting immunofluorescence. Results can enhance AMI significantly ameliorating depressive‐like behavior. Compared IL‐1β, IL‐18, TNF‐α, other markedly elevated MOD However, expressions these reduced varying degrees following or FLX. Analysis proteins revealed significant upregulation NLRP3, ASC, caspase‐1, GSDMD group; conversely, measures attenuated after intervention. Conclusion We have observed amelioration depression‐like upon administration AMI, suggesting that effect may be attributed inhibition NLRP3‐mediated pyroptosis. (The main findings summarized graphical abstract supplementary file.)

Язык: Английский

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