The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention DOI Creative Commons
Lele Cheng, Zixuan Meng, Qi Wang

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2021, Номер 8

Опубликована: Ноя. 12, 2021

Inflammation and nutrition as main factors can affect the prognosis of patients with chronic total coronary occlusion (CTO) undergoing percutaneous intervention (PCI). The C-reactive protein to albumin ratio (CAR) clarify inflammation status, which are highly related clinical outcomes. This study aims investigate association between CAR adverse cardiovascular events in CTO PCI. For this study, 664 were divided into three groups based on tertiles CAR. primary endpoint was all-cause mortality secondary major (MACE). Over a median follow-up 33.7 months, occurred 64 (9.6%) 170 (25.6%). higher represented worse death after adjustment for baseline risk factors. Adding values raised predictive value incidence but not MACE. capacity prediction improved addition traditional model.

Язык: Английский

Ginkgo biloba in the Aging Process: A Narrative Review DOI Creative Commons
Sandra Maria Barbalho, Rosa Direito, Lucas Fornari Laurindo

и другие.

Antioxidants, Год журнала: 2022, Номер 11(3), С. 525 - 525

Опубликована: Март 9, 2022

Neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, cancer, and other degenerative processes commonly appear with aging.

Язык: Английский

Процитировано

76

Inflammation in Obesity-Related HFpEF DOI Creative Commons

Subodh Verma,

Mark C. Petrie, Barry A. Borlaug

и другие.

Journal of the American College of Cardiology, Год журнала: 2024, Номер 84(17), С. 1646 - 1662

Опубликована: Авг. 30, 2024

Inflammation is thought to be an important mechanism for the development and progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In STEP-HFpEF Program, once-weekly 2.4 mg semaglutide improved failure-related symptoms, physical limitations, exercise function, reduced levels C-reactive protein (CRP), a biomarker inflammation, body weight in participants HFpEF. However, neither prevalence nor clinical characteristics patients who have various magnitudes inflammation context HFpEF been well described. Furthermore, whether beneficial effects on HF efficacy endpoints Program are modified by baseline has not fully established. Finally, relationship between reduction changes CRP across defined.

Язык: Английский

Процитировано

23

Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study DOI Creative Commons
Fengjun Zhang, Shanshan Deng, J. Zhang

и другие.

ESC Heart Failure, Год журнала: 2023, Номер 10(5), С. 2903 - 2913

Опубликована: Июль 14, 2023

Heart failure (HF) is a prevalent age-related cardiovascular disease with poor prognosis in the elderly population. This study aimed to establish causal relationship between ageing and HF by conducting bidirectional Mendelian randomization (MR) analysis on epigenetic age (a marker of ageing) HF.

Язык: Английский

Процитировано

19

Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults DOI Creative Commons
Xiaozhong Li, Jihong Wang,

Liyan Niu

и другие.

BMC Cardiovascular Disorders, Год журнала: 2023, Номер 23(1)

Опубликована: Июнь 10, 2023

The triglyceride glucose (TyG) index, a metric for estimating insulin resistance (IR), is linked with cardiovascular disease (CVD) morbidity and mortality among the population regardless of diabetic status. However, IR prevalence association between TyG index heart failure (HF) in Americans unclear.The Nation Health Nutrition Examination Survey (NHANES) (2009-2018) dataset was used. defined by homeostatic model assessment (HOMA-IR) > 2.0 1.5. calculated as Ln [fasting triglycerides (mg/dL) × fasting (mg/dL)/2]. A weighted logistic regression applied to evaluate HF.This study comprised 12,388 people, including 322 (2.6%) individuals HF. average found be 13.9% 22.7% cutoff values greater than 1.5, respectively. HOMA-IR showed moderate correlation (r = 0.30). There significant positive HF (per 1-unit increment; adjusted OR [aOR]: 1.34; 95% confidence interval [CI]: 1.02-1.76). Patients higher were associated (OR:1.41; CI: 1.01,1.95) (quartiles 4 vs 1-3). dyslipidemia, coronary disease, hypertension but not stroke (cerebrovascular disease).Our results show that does considerably increase from 2008 2018 American adults. noted index. HF, other diseases.

Язык: Английский

Процитировано

18

Brain–heart communication in health and diseases DOI
Wei Liu, Xinying Zhang, Zifeng Wu

и другие.

Brain Research Bulletin, Год журнала: 2022, Номер 183, С. 27 - 37

Опубликована: Фев. 22, 2022

Язык: Английский

Процитировано

23

Association of both depressive symptoms scores and specific depressive symptoms with all-cause and cardiovascular disease mortality DOI Creative Commons
Tao Liu,

Lili Wang,

Zhijian Zhu

и другие.

Annals of General Psychiatry, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 15, 2024

The presence of depression related to an increased risk all-cause and cardiovascular disease (CVD) mortality has been reported. However, studies conducted on certain specific depressive symptoms are scarce. Our purpose was assess the effect both scores CVD mortality.

Язык: Английский

Процитировано

5

Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies DOI
Tatjana Ruskovska, Irena Budić-Leto, Karla Fabiola Corral‐Jara

и другие.

Ageing Research Reviews, Год журнала: 2022, Номер 79, С. 101649 - 101649

Опубликована: Май 18, 2022

Язык: Английский

Процитировано

18

Molecular bases of comorbidities: present and future perspectives DOI Creative Commons
Jon Sánchez-Valle, Alfonso Valencia

Trends in Genetics, Год журнала: 2023, Номер 39(10), С. 773 - 786

Опубликована: Июль 22, 2023

Co-occurrence of diseases decreases patient quality life, complicates treatment choices, and increases mortality. Analyses electronic health records present a complex scenario comorbidity relationships that vary by age, sex, cohort under study. The study similarities between using 'omics data, such as genes altered in diseases, gene expression, proteome, microbiome, are fundamental to uncovering the origin of, potential for, comorbidities. Recent studies have produced first generation genetic interpretations for much 46% comorbidities described large cohorts. Integrating different sources molecular information artificial intelligence (AI) methods promising approaches They may help improve comorbidities, including repositioning drugs.

Язык: Английский

Процитировано

10

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease DOI Open Access
Hanne Leysen, Deborah Walter,

Lore Clauwaert

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(8), С. 4387 - 4387

Опубликована: Апрель 15, 2022

During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase unrepaired damage. This causes varying degrees of impaired functionality and increased risk mortality. One most effective anti-aging strategies involves interventions that combine simultaneous glucometabolic support augmented DNA damage protection/repair. Thus, it seems prudent develop therapeutic target this combinatorial approach. Studies have shown ADP-ribosylation factor (ARF) GTPase activating protein GIT2 (GIT2) acts as a keystone process. can control both repair glucose metabolism. Through vivo co-regulation analyses was found forms close coexpression-based relationship relaxin-3 receptor (RXFP3). Cellular RXFP3 expression is directly affected by oxidative stress. Overexpression or stimulation receptor, its endogenous ligand relaxin 3 (RLN3), regulate response processes. Interestingly, RLN3 insulin-like peptide has been multiple disease processes linked mechanisms, e.g., anxiety, depression, memory dysfunction, appetite, anti-apoptotic mechanisms. Here we discuss molecular mechanisms underlying various roles RXFP3/RLN3 signaling age-related disorders.

Язык: Английский

Процитировано

15

Associação entre diabetes e insuficiência cardíaca: mecanismos, fatores de risco e implicações clínicas DOI Creative Commons

Roger Antônio Morais Queiroz,

Hanna Victoria Marinho Oliveira Garcia,

Geraldo Magela Pereira

и другие.

Caderno Pedagógico, Год журнала: 2025, Номер 22(1), С. e13212 - e13212

Опубликована: Янв. 10, 2025

Introdução: a revisão investigou relação entre diabetes mellitus (DM) e insuficiência cardíaca congestiva (ICC), evidenciando o impacto negativo do DM nos desfechos clínicos, como mortalidade hospitalizações. Mecanismos fisiopatológicos, resistência à insulina, inflamação crônica remodelamento cardíaco, foram destacados fatores que agravam progressão da ICC. Metodologia: analisados estudos publicados 2013 2023, em inglês, português espanhol, selecionados nas bases PubMed, Scopus, Cochrane Library, LILACS SciELO. A seleção incluiu ensaios clínicos randomizados, revisões sistemáticas observacionais, priorizando aqueles com relevância qualidade abordassem ICC, intervenções terapêuticas clínicos. Resultados :os resultados demonstraram exacerba ICC por mecanismos fibrose miocárdica. Novas terapias, os inibidores cotransportadora de sódio-glicose tipo 2 (SGLT2), eficazes na redução hospitalizações mortalidade, além apresentarem benefícios renais significativos. Desenvolvimento: revisados enfatizaram importância um manejo integrado, equilibrando controle glicêmico farmacológicas, para abordar múltiplos fisiopatológicos. Estratégias multidisciplinares são fundamentais otimizar cuidados desfechos. Conclusão: reforça estratégias personalizadas no pacientes foco uso novas terapias cuidado multidisciplinar. Pesquisas futuras devem explorar populações sub-representadas, idosos frágeis renal avançada.

Процитировано

0