Frontiers in Cardiovascular Medicine,
Год журнала:
2021,
Номер
8
Опубликована: Ноя. 12, 2021
Inflammation
and
nutrition
as
main
factors
can
affect
the
prognosis
of
patients
with
chronic
total
coronary
occlusion
(CTO)
undergoing
percutaneous
intervention
(PCI).
The
C-reactive
protein
to
albumin
ratio
(CAR)
clarify
inflammation
status,
which
are
highly
related
clinical
outcomes.
This
study
aims
investigate
association
between
CAR
adverse
cardiovascular
events
in
CTO
PCI.
For
this
study,
664
were
divided
into
three
groups
based
on
tertiles
CAR.
primary
endpoint
was
all-cause
mortality
secondary
major
(MACE).
Over
a
median
follow-up
33.7
months,
occurred
64
(9.6%)
170
(25.6%).
higher
represented
worse
death
after
adjustment
for
baseline
risk
factors.
Adding
values
raised
predictive
value
incidence
but
not
MACE.
capacity
prediction
improved
addition
traditional
model.
Journal of the American College of Cardiology,
Год журнала:
2024,
Номер
84(17), С. 1646 - 1662
Опубликована: Авг. 30, 2024
Inflammation
is
thought
to
be
an
important
mechanism
for
the
development
and
progression
of
obesity-related
heart
failure
with
preserved
ejection
fraction
(HFpEF).
In
STEP-HFpEF
Program,
once-weekly
2.4
mg
semaglutide
improved
failure-related
symptoms,
physical
limitations,
exercise
function,
reduced
levels
C-reactive
protein
(CRP),
a
biomarker
inflammation,
body
weight
in
participants
HFpEF.
However,
neither
prevalence
nor
clinical
characteristics
patients
who
have
various
magnitudes
inflammation
context
HFpEF
been
well
described.
Furthermore,
whether
beneficial
effects
on
HF
efficacy
endpoints
Program
are
modified
by
baseline
has
not
fully
established.
Finally,
relationship
between
reduction
changes
CRP
across
defined.
ESC Heart Failure,
Год журнала:
2023,
Номер
10(5), С. 2903 - 2913
Опубликована: Июль 14, 2023
Heart
failure
(HF)
is
a
prevalent
age-related
cardiovascular
disease
with
poor
prognosis
in
the
elderly
population.
This
study
aimed
to
establish
causal
relationship
between
ageing
and
HF
by
conducting
bidirectional
Mendelian
randomization
(MR)
analysis
on
epigenetic
age
(a
marker
of
ageing)
HF.
BMC Cardiovascular Disorders,
Год журнала:
2023,
Номер
23(1)
Опубликована: Июнь 10, 2023
The
triglyceride
glucose
(TyG)
index,
a
metric
for
estimating
insulin
resistance
(IR),
is
linked
with
cardiovascular
disease
(CVD)
morbidity
and
mortality
among
the
population
regardless
of
diabetic
status.
However,
IR
prevalence
association
between
TyG
index
heart
failure
(HF)
in
Americans
unclear.The
Nation
Health
Nutrition
Examination
Survey
(NHANES)
(2009-2018)
dataset
was
used.
defined
by
homeostatic
model
assessment
(HOMA-IR)
>
2.0
1.5.
calculated
as
Ln
[fasting
triglycerides
(mg/dL)
×
fasting
(mg/dL)/2].
A
weighted
logistic
regression
applied
to
evaluate
HF.This
study
comprised
12,388
people,
including
322
(2.6%)
individuals
HF.
average
found
be
13.9%
22.7%
cutoff
values
greater
than
1.5,
respectively.
HOMA-IR
showed
moderate
correlation
(r
=
0.30).
There
significant
positive
HF
(per
1-unit
increment;
adjusted
OR
[aOR]:
1.34;
95%
confidence
interval
[CI]:
1.02-1.76).
Patients
higher
were
associated
(OR:1.41;
CI:
1.01,1.95)
(quartiles
4
vs
1-3).
dyslipidemia,
coronary
disease,
hypertension
but
not
stroke
(cerebrovascular
disease).Our
results
show
that
does
considerably
increase
from
2008
2018
American
adults.
noted
index.
HF,
other
diseases.
Annals of General Psychiatry,
Год журнала:
2024,
Номер
23(1)
Опубликована: Июль 15, 2024
The
presence
of
depression
related
to
an
increased
risk
all-cause
and
cardiovascular
disease
(CVD)
mortality
has
been
reported.
However,
studies
conducted
on
certain
specific
depressive
symptoms
are
scarce.
Our
purpose
was
assess
the
effect
both
scores
CVD
mortality.
Trends in Genetics,
Год журнала:
2023,
Номер
39(10), С. 773 - 786
Опубликована: Июль 22, 2023
Co-occurrence
of
diseases
decreases
patient
quality
life,
complicates
treatment
choices,
and
increases
mortality.
Analyses
electronic
health
records
present
a
complex
scenario
comorbidity
relationships
that
vary
by
age,
sex,
cohort
under
study.
The
study
similarities
between
using
'omics
data,
such
as
genes
altered
in
diseases,
gene
expression,
proteome,
microbiome,
are
fundamental
to
uncovering
the
origin
of,
potential
for,
comorbidities.
Recent
studies
have
produced
first
generation
genetic
interpretations
for
much
46%
comorbidities
described
large
cohorts.
Integrating
different
sources
molecular
information
artificial
intelligence
(AI)
methods
promising
approaches
They
may
help
improve
comorbidities,
including
repositioning
drugs.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(8), С. 4387 - 4387
Опубликована: Апрель 15, 2022
During
the
aging
process
our
body
becomes
less
well
equipped
to
deal
with
cellular
stress,
resulting
in
an
increase
unrepaired
damage.
This
causes
varying
degrees
of
impaired
functionality
and
increased
risk
mortality.
One
most
effective
anti-aging
strategies
involves
interventions
that
combine
simultaneous
glucometabolic
support
augmented
DNA
damage
protection/repair.
Thus,
it
seems
prudent
develop
therapeutic
target
this
combinatorial
approach.
Studies
have
shown
ADP-ribosylation
factor
(ARF)
GTPase
activating
protein
GIT2
(GIT2)
acts
as
a
keystone
process.
can
control
both
repair
glucose
metabolism.
Through
vivo
co-regulation
analyses
was
found
forms
close
coexpression-based
relationship
relaxin-3
receptor
(RXFP3).
Cellular
RXFP3
expression
is
directly
affected
by
oxidative
stress.
Overexpression
or
stimulation
receptor,
its
endogenous
ligand
relaxin
3
(RLN3),
regulate
response
processes.
Interestingly,
RLN3
insulin-like
peptide
has
been
multiple
disease
processes
linked
mechanisms,
e.g.,
anxiety,
depression,
memory
dysfunction,
appetite,
anti-apoptotic
mechanisms.
Here
we
discuss
molecular
mechanisms
underlying
various
roles
RXFP3/RLN3
signaling
age-related
disorders.
