Ginkgo biloba in the Aging Process: A Narrative Review

Antioxidants, Journal Year: 2022, Volume and Issue: 11(3), P. 525 - 525

Published: March 9, 2022

Neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, cancer, and other degenerative processes commonly appear with aging.

Language: Английский

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Inflammation in Obesity-Related HFpEF

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(17), P. 1646 - 1662

Published: Aug. 30, 2024

Inflammation is thought to be an important mechanism for the development and progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In STEP-HFpEF Program, once-weekly 2.4 mg semaglutide improved failure-related symptoms, physical limitations, exercise function, reduced levels C-reactive protein (CRP), a biomarker inflammation, body weight in participants HFpEF. However, neither prevalence nor clinical characteristics patients who have various magnitudes inflammation context HFpEF been well described. Furthermore, whether beneficial effects on HF efficacy endpoints Program are modified by baseline has not fully established. Finally, relationship between reduction changes CRP across defined.

Language: Английский

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Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults

BMC Cardiovascular Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 10, 2023

The triglyceride glucose (TyG) index, a metric for estimating insulin resistance (IR), is linked with cardiovascular disease (CVD) morbidity and mortality among the population regardless of diabetic status. However, IR prevalence association between TyG index heart failure (HF) in Americans unclear.The Nation Health Nutrition Examination Survey (NHANES) (2009-2018) dataset was used. defined by homeostatic model assessment (HOMA-IR) > 2.0 1.5. calculated as Ln [fasting triglycerides (mg/dL) × fasting (mg/dL)/2]. A weighted logistic regression applied to evaluate HF.This study comprised 12,388 people, including 322 (2.6%) individuals HF. average found be 13.9% 22.7% cutoff values greater than 1.5, respectively. HOMA-IR showed moderate correlation (r = 0.30). There significant positive HF (per 1-unit increment; adjusted OR [aOR]: 1.34; 95% confidence interval [CI]: 1.02-1.76). Patients higher were associated (OR:1.41; CI: 1.01,1.95) (quartiles 4 vs 1-3). dyslipidemia, coronary disease, hypertension but not stroke (cerebrovascular disease).Our results show that does considerably increase from 2008 2018 American adults. noted index. HF, other diseases.

Language: Английский

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Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study

ESC Heart Failure, Journal Year: 2023, Volume and Issue: 10(5), P. 2903 - 2913

Published: July 14, 2023

Heart failure (HF) is a prevalent age-related cardiovascular disease with poor prognosis in the elderly population. This study aimed to establish causal relationship between ageing and HF by conducting bidirectional Mendelian randomization (MR) analysis on epigenetic age (a marker of ageing) HF.

Language: Английский

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Brain–heart communication in health and diseases

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 183, P. 27 - 37

Published: Feb. 22, 2022

Language: Английский

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Association of both depressive symptoms scores and specific depressive symptoms with all-cause and cardiovascular disease mortality

Annals of General Psychiatry, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 15, 2024

The presence of depression related to an increased risk all-cause and cardiovascular disease (CVD) mortality has been reported. However, studies conducted on certain specific depressive symptoms are scarce. Our purpose was assess the effect both scores CVD mortality.

Language: Английский

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Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 79, P. 101649 - 101649

Published: May 18, 2022

Language: Английский

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Molecular bases of comorbidities: present and future perspectives

Trends in Genetics, Journal Year: 2023, Volume and Issue: 39(10), P. 773 - 786

Published: July 22, 2023

Co-occurrence of diseases decreases patient quality life, complicates treatment choices, and increases mortality. Analyses electronic health records present a complex scenario comorbidity relationships that vary by age, sex, cohort under study. The study similarities between using 'omics data, such as genes altered in diseases, gene expression, proteome, microbiome, are fundamental to uncovering the origin of, potential for, comorbidities. Recent studies have produced first generation genetic interpretations for much 46% comorbidities described large cohorts. Integrating different sources molecular information artificial intelligence (AI) methods promising approaches They may help improve comorbidities, including repositioning drugs.

Language: Английский

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Associação entre diabetes e insuficiência cardíaca: mecanismos, fatores de risco e implicações clínicas

Caderno Pedagógico, Journal Year: 2025, Volume and Issue: 22(1), P. e13212 - e13212

Published: Jan. 10, 2025

Introdução: a revisão investigou relação entre diabetes mellitus (DM) e insuficiência cardíaca congestiva (ICC), evidenciando o impacto negativo do DM nos desfechos clínicos, como mortalidade hospitalizações. Mecanismos fisiopatológicos, resistência à insulina, inflamação crônica remodelamento cardíaco, foram destacados fatores que agravam progressão da ICC. Metodologia: analisados estudos publicados 2013 2023, em inglês, português espanhol, selecionados nas bases PubMed, Scopus, Cochrane Library, LILACS SciELO. A seleção incluiu ensaios clínicos randomizados, revisões sistemáticas observacionais, priorizando aqueles com relevância qualidade abordassem ICC, intervenções terapêuticas clínicos. Resultados :os resultados demonstraram exacerba ICC por mecanismos fibrose miocárdica. Novas terapias, os inibidores cotransportadora de sódio-glicose tipo 2 (SGLT2), eficazes na redução hospitalizações mortalidade, além apresentarem benefícios renais significativos. Desenvolvimento: revisados enfatizaram importância um manejo integrado, equilibrando controle glicêmico farmacológicas, para abordar múltiplos fisiopatológicos. Estratégias multidisciplinares são fundamentais otimizar cuidados desfechos. Conclusão: reforça estratégias personalizadas no pacientes foco uso novas terapias cuidado multidisciplinar. Pesquisas futuras devem explorar populações sub-representadas, idosos frágeis renal avançada.

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Gut Microbiota in Heart Failure—The Role of Inflammation

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 911 - 911

Published: April 9, 2025

Heart failure (HF) has become an immense health concern affecting almost 1–2% of the population globally. It is a complex syndrome characterized by activation sympathetic nervous system and Renin–Angiotensin–Aldosterone (RAAS) axis as well endothelial dysfunction, oxidative stress, inflammation. The recent literature points towards interaction between intestinal flora heart, also called gut–heart axis. human gastrointestinal tract naturally inhabited various microbes, which are distinct for each patient, regulating functions many organs. Alterations gut microbiome, process dysbiosis, may result in systemic diseases have been associated with heart through inflammatory autoimmune mechanisms. disorder permeability favors translocation microbes metabolites capable inducing inflammation, thus further contributing to deterioration normal cardiac function. Besides diet modifications exercise training, studies revealed possible microbiota targeted treatments managing failure. aim this review demonstrate impact environment induced microbiome its on elucidation these novel therapeutic approaches.

Language: Английский

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