High levels of high-sensitivity C reactive protein to albumin ratio can increase the risk of cardiovascular disease

Journal of Epidemiology & Community Health, Год журнала: 2023, Номер 77(11), С. 721 - 727

Опубликована: Авг. 10, 2023

The high levels of C reactive protein (CRP) to albumin ratio (CAR) is thought increase the risk poor outcomes for cancer and cardiovascular disease (CVD). However, association between CAR CVD in Chinese community population has not been investigated.The aim this study was investigate population.A total 62 067 participants without a history or were included study. Kaplan-Meier survival curves used calculate cumulative incidence endpoint events quartile groups, results tested by log-rank test. Fine-Gray model analyse competing death. C-index, Net Reclassification Index (NRI) Integrated Discrimination Improvement (IDI) different indicators calculated distinguish predictive performance indicators.During an average follow-up period 10.3±2.1 years, 4025 developed CVD. In multivariable Cox regression analysis, compared with Q1 group, 3 showed that hazard (HR) (95% confidence interval (95%CI)) Q4 group 1.26 (1.15 1.38) (p<0.01), HR CI) per 1 SD 1.06 (1.03 1.08) (p<0.01). continuous NRI IDI predicting 10-year 73.48%, 0.1366 (0.1049 0.1684) (p<0.01) 0.0002 (0.0001 0.0004) respectively, which higher than those hs-CRP (C-index:0.7344, NRI:0.0711, IDI: 0.0001) (C-index:0.7339, NRI: -0.0090, 0.0000).High can better alone.

Язык: Английский

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The relationship between C-reactive protein/albumin ratio and mortality in hypertensive patients: A national cohort study

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2024, Номер 34(7), С. 1601 - 1609

Опубликована: Фев. 27, 2024

Background and Aims:The impact of inflammation on the prognosis hypertension has received some attention.The current study examined association between Creactive protein to albumin ratio (CAR), a novel indicator inflammatory response, mortality in individuals with hypertension. Methods results:A total 9,561 eligible diagnosed were included final analysis.CAR was calculated as C-reactive serum concentration.Patients categorized into tertiles based their baseline CAR levels.The Kaplan-Meier survival method employed compare times patients throughout follow-up period.Multivariable analysis conducted using Cox proportional regression model.In entire population, 3,262 (27%) experienced all-cause mortality.Patients tertile 3 exhibited higher risk (23% vs. 28% 31%, P < 0.001) comparison those other tertiles.The findings from multivariable demonstrated that when 1 used reference group, highest displayed 60% increased (HR, 1.60 [95%CI,.09]P 0.001). Conclusion:Among hypertensive patients, elevated found be associated an mortality.Therefore, might for stratification within this facilitating implementation closer optimization treatment strategies.

Язык: Английский

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Evaluation of the Prognostic Role of Neutrophil-Lymphocyte Ratio, C-Reactive Protein-Albumin Ratio, and Platelet-Lymphocyte Ratio in Patients with the Co-Presentation of Coronary Artery Disease and COVID-19

Infection and Drug Resistance, Год журнала: 2024, Номер Volume 17, С. 885 - 897

Опубликована: Март 1, 2024

Aim: The purpose of this study was to investigate the role neutrophil-lymphocyte ratio (NLR), C-reactive protein-albumin (CAR), and platelet-lymphocyte (PLR) in prognosis patients with coronary artery disease (CAD) complicated coronavirus 2019 (COVID-19). Methods: This included 265 patients. A receiver operating characteristic (ROC) curve analysis performed preliminarily evaluate predictive ability NLR, CAR, PLR for all-cause death. primary outcome death during hospitalization, while secondary outcomes were cardiovascular respiratory failure Cox proportional hazard model adjusted covariates used analyze cumulative risk outcomes. We also conducted subgroup analyses based on acute chronic characteristics CAD. Propensity score matching (PSM) further robustness outcome. Results: ROC results showed that area under (AUC) values 0.686 (95% CI 0.592– 0.781, P< 0.001) 0.749 0.667– 0.832, 0.571 0.455– 0.687, P=0.232) PLR. trends NLR did not affect (P=0.096 P=0.544 trend, respectively), but a higher CAR level corresponded (P< 0.001 trend). Similarly, death, PSM consistent total cohort. Conclusion: In CAD COVID-19, not. Keywords: disease, 2019, ratio,

Язык: Английский

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High levels of C‐reactive protein‐to‐albumin ratio (CAR) are associated with a poor prognosis in patients with severe fever with thrombocytopenia syndrome in early stage

Journal of Medical Virology, Год журнала: 2022, Номер 94(11), С. 5375 - 5384

Опубликована: Июль 6, 2022

Abstract C‐reactive protein‐to‐albumin ratio (CAR) can be used to assess the prognosis of various diseases. This study aimed evaluate relationship between CAR on patients with severe fever thrombocytopenia syndrome (SFTS). included 155 SFTS from Public Health Clinical Center Dalian January December 2021. They were divided into survival and deceased groups based clinical prognosis. The independent risk factors for poor at an early stage determined by Cox regression. efficacy prediction was assessed receiver operating characteristic (ROC) curve. A total in this study, average age 61.98± 11.70 years, including 77 males 65 females. mortality rate enrolled 14.19%. Multivariate regression indicated that (hazard = 2.585, 95% confidence interval [CI] 1.405–4.753, p 0.002) could predictor stage. had AUC 0.781 (95% CI, 0.665–0.898, 0.000), a cutoff value 0.57, sensitivity 0.77, specificity 0.80, better predictive efficacy, compared neutrophil‐to‐lymphocyte (NLR). High levels are associated patients, as patients.

Язык: Английский

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A novel inflammatory biomarker, high-sensitivity C-reactive protein-to-albumin ratio, is associated with 5-year outcomes in patients with type 2 diabetes who undergo percutaneous coronary intervention

Diabetology & Metabolic Syndrome, Год журнала: 2023, Номер 15(1)

Опубликована: Фев. 6, 2023

Patients with coronary artery disease (CAD) combined diabetes have a higher risk of cardiovascular events, and high-sensitivity C-reactive protein (hs-CRP)-to-albumin ratio (CAR) is novel inflammatory biomarker. However, whether the CAR can identify high-risk patients CAD type 2 (T2DM) remains unclear.The present study was based on prospective observational cohort 10,724 individuals who undergo percutaneous intervention (PCI) in Fu Wai Hospital throughout year 2013 consecutively enrolled. The primary endpoint all-cause mortality. secondary cardiac calculated formula: hs-CRP (mg/L)/albumin (g/L). According to optimal cut-off value for mortality, were divided into (CAR-H) lower (CAR-L) groups.A total 2755 T2DM underwent PCI received dual antiplatelet therapy finally During follow-up 5 years (interquartile range: 5.0-5.1 years), 126 (4.6%) mortalities 74 (2.7%) recorded. In multivariable Cox model, CAR-H associated mortality (hazard [HR]: 1.634, 95% confidence interval [CI] 1.121-2.380, p = 0.011) (HR: 1.733, CI 1.059-2.835, 0.029) compared CAR-L. When comparing predictive value, superior (area under curve [AUC] 0.588 vs. 0.580, 0.002) (AUC 0.602 0.593, 0.004).In this real-world study, level worse 5-year outcomes among diabetic PCI.

Язык: Английский

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Impact of Preoperative Biliary Stenting on Intestinal Dysfunction and Perioperative Complications After Pylorus-Preserving Pancreaticoduodenectomy

Medicina, Год журнала: 2025, Номер 61(3), С. 391 - 391

Опубликована: Фев. 24, 2025

Background and Objectives: Preoperative biliary stenting (PBS) is commonly used to manage obstructive jaundice in patients undergoing pylorus-preserving pancreaticoduodenectomy (PPPD). However, the impact of PBS on intestinal barrier function perioperative complications remains controversial. This study aims evaluate effect dysfunction surgical outcomes, focusing influence stent duration. Materials Methods: In this prospective cohort study, 235 PPPD for resectable pancreatic neoplasms at Timișoara Municipal Emergency Clinical Hospital (2016–2024) were analyzed. Patients divided into two groups: those with (n = 98) without 137). Intestinal was assessed pre- postoperatively using biomarkers such as zonulin, fecal calprotectin, serum lipopolysaccharides (LPS). Perioperative including fistula, delayed gastric emptying (DGE), infections, hospital stay, compared. Additionally, outcomes stratified based duration (2–3 weeks vs. 3–4 weeks). Results: associated significantly higher levels LPS postoperatively, indicating compromised function. The stented group had a incidence fistulas (Grade B/C: 27.5% 13.1%, p < 0.01), DGE (25.5% 0.008), postoperative infections (34.7% 17.5%, 0.002), prolonged stay (16.9 ± 4.2 days 14.5 3.7 days, 0.019). Prolonged (3–4 weeks) worse compared shorter durations weeks), increased rates sepsis, ICU (p 0.05 all comparisons). Conclusions: dysfunction, systemic inflammation, following PPPD. (>3 further exacerbate these risks. Limiting 2–3 weeks, alongside optimized management, may help reduce morbidity improve outcomes.

Язык: Английский

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Association of high-sensitivity C-reactive protein to albumin ratio with all-cause and cardiac death in coronary heart disease individuals: A retrospective NHANES study

PLoS ONE, Год журнала: 2025, Номер 20(5), С. e0322281 - e0322281

Опубликована: Май 28, 2025

Background This research aimed to explore the association of high-sensitivity C-reactive protein albumin ratio (CAR) with death events in community-based patients coronary heart disease (CHD). Methods 624 CHD participants were followed for 36 months using data from 2015–2018 National Health and Nutrition Examination Survey (NHANES). The CAR was dichotomized at 0.075 mg/g stratify inflammation levels. Relationships between CAR, (hsCRP), (ALB) all-cause cardiac all subgroups analyzed restricted cubic spline (RCS), Kaplan-Meier survival curves Cox proportional hazards models. Results Both hsCRP showed positive correlations risk while ALB exhibited a U-shaped correlation but negative risk. high-CAR group had higher risks (P = 0.04) 0.02). hazard ratios (HR) (95% confidence intervals (CI)) 1.77 (1.15–2.74) 0.010), it 2.99 (1.44–6.22) 0.003) death. No significant interaction observed subgroup analyses. Conclusions A threshold effectively distinguished high low risks. Elevated significantly increased community patients.

Язык: Английский

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The Novel Predictive Biomarkers for Type 2 Diabetes Mellitus in Active Pulmonary Tuberculosis Patients

Infection and Drug Resistance, Год журнала: 2022, Номер Volume 15, С. 4529 - 4539

Опубликована: Авг. 1, 2022

This study was to explore the predictive value of monocyte high-density lipoprotein cholesterol ratio (MHR), neutrophils (NHR), C-reactive protein-to-lymphocyte (CLR), and protein-to-albumin (CAR) for type 2 diabetes mellitus (T2DM) in patients with active pulmonary tuberculosis (APTB).A total 991 (APTB) (201 T2DM) were hospitalized Department Tuberculosis, Wuhan Jinyintan Hospital, Tongji Medical College, Huazhong University Science Technology included. The routine blood examination indicators biochemical parameters collected calculate MHR, NHR, CLR, CAR. Pearson correlation analysis, Univariate Logistic regression receiver operating characteristic (ROC) curve analysis performed assess CAR APTB-T2DM patients.The levels significantly higher than APTB-no T2DM (P < 0.05). Additionally, have a positive fasting glucose whole population. However, patients, not correlated glucose, only CLR positively glucose. area under (AUC) predicting 0.632, 0.72, 0.715, 0.713, respectively. Further, univariate logistic analyses showed that independent risk factors 0.01). quartiles used divide APTB into four groups further analysis. prevalence individuals as values increased 0.05).MHR, are simple practicable inflammatory could be assessing APTB. greater possibility diagnosed NHR values. Therefore, more attention should given indicator

Язык: Английский

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Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke

Frontiers in Neurology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 15, 2022

The inflammatory response plays an important role in ischemic stroke, and the incidence of stroke young adults has increased rapidly recent years. C-reactive protein-to-albumin ratio (CAR) is a new index that reflects overall status patients with major diseases; however, no studies have reported relationship between CAR stroke.The participants' baseline characteristics laboratory examination results, including CAR, were obtained at admission. modified Rankin Scale (mRS) scores 30-day 90-day follow-ups from all patients. All participants included study classified into four groups according to quartiles (Q1-Q4). Logistic regression was used analyze different levels adverse outcomes (mRS 3-6 mRS 2-6). We also plotted receiver operating characteristic curves for clinical calculated area under curve cutoff values.A total 630 enrolled study. In multivariate logistic model, follow-up, Q3 Q4 (significantly CAR) showed elevated risk score 2-6 (odds [OR]: 2.94; 95% confidence interval [CI]: 1.40-6.16, p < 0.01; OR: 4.01; CI: 1.88-8.91, 0.01). At still (Q3, 2.76; 1.30-5.86, Q4, 2.63; 1.22-5.65, 0.01).A significantly independently associated stroke.

Язык: Английский

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Triglyceride-glucose index and hsCRP-to-albumin ratio as predictors of major adverse cardiovascular events in STEMI patients with hypertension

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 15, 2024

This study aimed to evaluate the association between triglyceride-glucose (TyG) index and high-sensitivity C-reactive protein-to-albumin ratio (hsCAR) prognosis of patients with STEMI hypertension. A total 699 diagnosed hypertension were included in this database. Compared low TyG group (< 7.8), high (≥ 7.8) was associated an increased risk MACE (HR 2.09, 95% CI = 1.58–2.77; P < 0.001). Similarly, a higher hsCAR 0.15) linked 1.46, 1.12–1.90; 0.005). Subsequently, we categorized population into four groups based on defined cutoff points. TyG–low subgroup, other three subgroups demonstrated elevated MACE. Among treated PCSK9 SGLT2 inhibitors, combined effect attenuated. Finally, The model exhibited optimal performance (AUC 0.71, 0.67–0.75; demonstrates that provide strong predictive power. synergistic utilization offers comprehensive approach cardiovascular assessment.

Язык: Английский

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